{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T10:53:47Z","timestamp":1791888827138,"version":"4.3.4"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2004,10,7]],"date-time":"2004-10-07T00:00:00Z","timestamp":1097107200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,10,7]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Common variable immunodeficiency (CVID) represents a heterogeneous group of antibody deficiency syndromes, characterized by defective antibody production in which T cell deficiency may play a pathogenic role. A subgroup of CVID patients has impaired in vitro T cell proliferation. Using microarray analyses of T cells from these patients, we found a gene expression pattern different from healthy controls and patients with X-linked agammaglobulinaemia. The profile of the differentially expressed genes suggests enhanced cytotoxic effector functions, antigen experienced or chronically activated T cells and a predominance of CCR7\u2013 T cells. Further experiments using flow cytometry revealed a striking predominance of CCR7\u2013 T cells in a subgroup of CVID patients, and an association with impaired T cell proliferation. Our observations indicate that a predominance of CCR7\u2013 T cells with effector-memory cell features and with reduced proliferative capacity may characterize a subgroup of CVID.<\/jats:p>","DOI":"10.1111\/j.1365-2249.2004.02630.x","type":"journal-article","created":{"date-parts":[[2004,10,20]],"date-time":"2004-10-20T11:44:23Z","timestamp":1098272663000},"page":"278-289","source":"Crossref","is-referenced-by-count":32,"title":["Gene expression analysis of peripheral T cells in a subgroup of common variable immunodeficiency shows predominance of CCR7\u2013 effector-memory T cells"],"prefix":"10.1093","volume":"138","author":[{"given":"A M","family":"HOLM","sequence":"first","affiliation":[{"name":"Section for Clinical Immunology and Infectious Diseases, Medical Department, The National Hospital, Oslo"},{"name":"Research Institute for Internal Medicine, The National Hospital, Oslo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E A","family":"SIVERTSEN","sequence":"additional","affiliation":[{"name":"Department for Immunology, The Norwegian Radiumhospital, Oslo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S H","family":"TUNHEIM","sequence":"additional","affiliation":[{"name":"Center for Occupational and Environmental Medicine, The National Hospital, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"HAUG","sequence":"additional","affiliation":[{"name":"Center for Occupational and Environmental Medicine, The National Hospital, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"BJERKELI","sequence":"additional","affiliation":[{"name":"Research Institute for Internal Medicine, The National Hospital, Oslo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"YNDESTAD","sequence":"additional","affiliation":[{"name":"Research Institute for Internal Medicine, The National Hospital, Oslo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"AUKRUST","sequence":"additional","affiliation":[{"name":"Section for Clinical Immunology and Infectious Diseases, Medical Department, The National Hospital, Oslo"},{"name":"Research Institute for Internal Medicine, The National Hospital, Oslo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S S","family":"FR\u00d8LAND","sequence":"additional","affiliation":[{"name":"Section for Clinical Immunology and Infectious Diseases, Medical Department, The National Hospital, Oslo"},{"name":"Research Institute for Internal Medicine, The National Hospital, Oslo"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2004,10,20]]},"reference":[{"issue":"Suppl. 1","key":"2022010901431195800_b1","first-page":"1","article-title":"Primary immunodeficiency diseases. 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