{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T07:51:02Z","timestamp":1789977062484,"version":"4.0.1"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2004,11,12]],"date-time":"2004-11-12T00:00:00Z","timestamp":1100217600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,11,12]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n               <jats:p>Although mannose-binding lectin (MBL) is known to be involved in the primary defense against microorganisms, there are emerging lines of evidence for an active proinflammatory role for MBL in different chronic diseases. In this study we determined the circulating levels of MBL in patients with rheumatic heart disease (RHD). A total of 100 patients (77 women, 23 men; mean age 45\u00b78 \u00b1 11\u2003years, range 19\u201376\u2003years) with chronic RHD, and a previous diagnosis of rheumatic fever, were studied. Transthoracic echocardiography was performed in all patients to evaluate valvular heart disease. Ninety-nine healthy individuals matched for age, sex and ethnic origin were included as controls. MBL concentration was measured by enzyme-linked immunosorbent assay and C3 and C4 levels by turbidimetry. MBL levels were significantly higher in patients with RHD than in healthy subjects (mean \u00b1 SEM: 3036\u00b72 \u00b1 298\u00b79\u2003ng\/ml versus 1942\u00b76 \u00b1 185\u00b75\u2003ng\/ml, P\u2003&amp;lt;\u20030\u00b7003). In addition, MBL deficiency was more prevalent in controls (17\u00b71%) than in patients (9% P\u2003&amp;lt;\u20030\u00b709). Concentrations of C4 were within the normal range (22\u00b77 \u00b1 0\u00b78\u2003mg\/dl, normal: 10\u00b70\u201340\u00b70\u2003mg\/dl), while C3 concentrations were found to be elevated (109\u00b72 \u00b1 3\u00b76\u2003mg\/dl, normal: 50\u00b70\u201390\u00b70\u2003mg\/dl). No correlation was observed between serum MBL levels and valve area or the type of surgical procedure. The significantly elevated circulating MBL levels in patients with RHD together with the greater prevalence of MBL deficiency in controls suggest that MBL may cause undesirable complement activation contributing to the pathogenesis of RHD.<\/jats:p>","DOI":"10.1111\/j.1365-2249.2004.02645.x","type":"journal-article","created":{"date-parts":[[2004,11,15]],"date-time":"2004-11-15T19:14:48Z","timestamp":1100546088000},"page":"521-525","source":"Crossref","is-referenced-by-count":66,"title":["Significantly increased levels of mannose-binding lectin (MBL) in rheumatic heart disease: a beneficial role for MBL deficiency"],"prefix":"10.1093","volume":"138","author":[{"given":"M D","family":"SCHAFRANSKI","sequence":"first","affiliation":[{"name":"Laboratory of Immunopathology, Department of Clinical Pathology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"STIER","sequence":"additional","affiliation":[{"name":"Cardiology Clinic, Hospital de Cl\u00ednicas, Federal University of Paran\u00e1, Curitiba, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"NISIHARA","sequence":"additional","affiliation":[{"name":"Laboratory of Immunopathology, Department of Clinical Pathology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I J T","family":"MESSIAS-REASON","sequence":"additional","affiliation":[{"name":"Laboratory of Immunopathology, Department of Clinical Pathology"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2004,11,12]]},"reference":[{"key":"2022010901424118300_b1","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1080\/00325481.1993.11701686","article-title":"Rheumatic mitral stenosis","volume":"93","author":"Feldman","year":"1993","journal-title":"Postgrad Med"},{"key":"2022010901424118300_b2","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0889-857X(05)70007-7","article-title":"Rheumatic fever. 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