{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T13:09:13Z","timestamp":1762520953370},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2005,1,26]],"date-time":"2005-01-26T00:00:00Z","timestamp":1106697600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,1,26]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The fibrotic and antiapoptotic effects of insulin-like growth factors (IGF) are mediated by type I IGF receptor (IGF-1R). IGFs could play a role in intestinal stricturing and in the maintenance of inflammation in Crohn's disease (CD). We aimed to describe IGF-1R expression in CD intestinal lesions, to compare it to other intestinal inflammatory diseases and to correlate it with fibrosis and apoptosis. IGF-1R expression and apoptosis (active caspase-3) were studied by immunohistochemistry. Surgical intestinal specimens [17\u2003CD, nine controls, six diverticulitis and four ulcerative colitis (UC)] were used. IGF-1R was expressed transmurally mainly by inflammatory cells (IC) and smooth muscle cells, both in diseased intestine and controls. IGF-1R positive IC were increased in the mucosa and the submucosa of CD (P &amp;lt; 0\u00b7007), and in involved areas compared to uninvolved areas (P = 0\u00b703). In UC, the number of IGF-1R positive IC was only increased in the mucosa, and was not different from controls in the submucosa. In diverticulitis, the number of IGF-1R positive IC did not differ from controls. In CD submucosa, IGF-1R expression in IC was inversely correlated with apoptosis in uninvolved areas (P = 0\u00b701). Expression of IGF-1R in submucosal fibroblast-like cells, subserosal adipocytes and hypertrophic nervous plexi was specific for CD. We have shown a transmural altered expression of IGF-1R in CD. This may suggest a role for IGF-1R in the maintenance of chronic inflammation and stricture formation in CD.<\/jats:p>","DOI":"10.1111\/j.1365-2249.2004.02724.x","type":"journal-article","created":{"date-parts":[[2005,2,23]],"date-time":"2005-02-23T13:14:44Z","timestamp":1109164484000},"page":"526-533","source":"Crossref","is-referenced-by-count":22,"title":["Altered expression of type I insulin-like growth factor receptor in Crohn's disease"],"prefix":"10.1093","volume":"139","author":[{"given":"F","family":"El Yafi","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, CHU of Li\u00e8ge"},{"name":"Laboratory of Molecular Oncology, University of Li\u00e8ge"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Winkler","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Oncology, University of Li\u00e8ge"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Delvenne","sequence":"additional","affiliation":[{"name":"Department of Pathology, CHU of Li\u00e8ge"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Boussif","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Oncology, University of Li\u00e8ge"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Belaiche","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, CHU of Li\u00e8ge"},{"name":"CTCM and CBIG, University of Li\u00e8ge, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Louis","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, CHU of Li\u00e8ge"},{"name":"CTCM and CBIG, University of Li\u00e8ge, 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