{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T10:19:11Z","timestamp":1761128351495},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2005,6,16]],"date-time":"2005-06-16T00:00:00Z","timestamp":1118880000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,6,16]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>The aim of this study was to assess the effect of Adalimumab on different immune parameters in patients with RA. Adalimumab was administered (40\u2003mg every other week for 26\u2003weeks) to eight patients with RA that were refractory to conventional drug therapy. Peripheral blood samples were obtained at days 0, 15 and 180 of Adalimumab therapy, and the following immune parameters were assessed: Number, phenotype, and function of regulatory T lymphocytes. The induction of apoptosis of immune cells and the in vitro and in vivo reactivity towards M. tuberculosis were also analysed. All patients responded to Adalimumab (ACR response 50\u201370), and a modest but significant increase in the number and function of regulatory T cells was observed at day 15 of anti-TNF-\u03b1 therapy. In addition, an increased percent of apoptotic cells was detected in the peripheral blood at day 15 of Adalimumab therapy. Unexpectedly, most of these effects were not further observed at day 180. However, two patients showed a persistent and marked reduction in the reactivity to M. tuberculosis. Although we have found that Adalimumab affects the number and function of regulatory T lymphocytes, and the apoptosis of immune cells, these effects are transient and its possible causal relationship with the therapeutic activity of this biological agent remains to be determined. Nevertheless, the down-regulatory effect of Adalimumab on the reactivity to M. tuberculosis could be related to an enhanced risk of tuberculosis reactivation.<\/jats:p>","DOI":"10.1111\/j.1365-2249.2005.02859.x","type":"journal-article","created":{"date-parts":[[2005,7,1]],"date-time":"2005-07-01T17:55:07Z","timestamp":1120240507000},"page":"372-380","source":"Crossref","is-referenced-by-count":52,"title":["Immune effects of therapy with Adalimumab in patients with rheumatoid arthritis"],"prefix":"10.1093","volume":"141","author":[{"given":"M","family":"Vigna-P\u00e9rez","sequence":"first","affiliation":[{"name":"Departamento de Inmunolog\u00eda, Facultad de Medicina, UASLP, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Abud-Mendoza","sequence":"additional","affiliation":[{"name":"Unidad Regional de Reumatolog\u00eda y Osteoporosis, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Portillo-Salazar","sequence":"additional","affiliation":[{"name":"Departamento de Inmunolog\u00eda, Facultad de Medicina, UASLP, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Alvarado-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Departamento de Inmunolog\u00eda, Facultad de Medicina, UASLP, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Cuevas-Orta","sequence":"additional","affiliation":[{"name":"Unidad Regional de Reumatolog\u00eda y Osteoporosis, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Moreno-Vald\u00e9s","sequence":"additional","affiliation":[{"name":"Unidad Regional de Reumatolog\u00eda y Osteoporosis, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Baranda","sequence":"additional","affiliation":[{"name":"Departamento de Inmunolog\u00eda, Facultad de Medicina, UASLP, M\u00e9xico"},{"name":"Departamento de Medicina Interna, Hospital Central Dr Ignacio Morones Prieto, San Luis Potos\u00ed, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O","family":"Paredes-Saharopulos","sequence":"additional","affiliation":[{"name":"Departamento de Inmunolog\u00eda, Facultad de Medicina, UASLP, M\u00e9xico"},{"name":"Departamento de Medicina Interna, Hospital Central Dr Ignacio Morones Prieto, San Luis Potos\u00ed, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Gonz\u00e1lez-Amaro","sequence":"additional","affiliation":[{"name":"Departamento de Inmunolog\u00eda, Facultad de Medicina, UASLP, 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