{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T10:43:43Z","timestamp":1789987423843,"version":"4.0.1"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2005,7,24]],"date-time":"2005-07-24T00:00:00Z","timestamp":1122163200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,7,28]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Concanavarin-A (conA)-stimulated peripheral blood mononuclear cells (PBMNC) from patients with idiopathic nephrotic syndrome (INS) produce putative factors that increase vascular permeability. These factors are expressed in the nephrotic phase but are reduced in the convalescent phase. To identify the genes that are expressed only in the nephrotic phase, we performed cDNA subtraction using conA-stimulated PBMNC from three patients with INS. We isolated several gene transcripts in all three subtracted cDNA libraries. Among these genes, IgE-dependent histamine-releasing factor (HRF) was overexpressed in the nephrotic phase not only at the mRNA level but also at the protein level in another 10 patients with INS. Moreover, we found increased secretion of HRF from conA-stimulated PBMNC in the nephrotic phase. The results suggest that HRF is involved in the pathogenesis of idiopathic nephrotic syndrome.<\/jats:p>","DOI":"10.1111\/j.1365-2249.2005.02890.x","type":"journal-article","created":{"date-parts":[[2005,9,13]],"date-time":"2005-09-13T10:01:14Z","timestamp":1126605674000},"page":"162-166","source":"Crossref","is-referenced-by-count":6,"title":["Expression of immunoglobulin E-dependent histamine-releasing factor in idiopathic nephrotic syndrome of childhood"],"prefix":"10.1093","volume":"142","author":[{"given":"S","family":"Toyabe","sequence":"first","affiliation":[{"name":"Division of Paediatrics, Department of Homeostatic Regulation and Development, Niigata Graduate School of Medical and Dental Sciences, Niigata University Medical and Dental Hospital, Niigata City, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Division of Paediatrics, Department of Homeostatic Regulation and Development, Niigata Graduate School of Medical and Dental Sciences, Niigata University Medical and Dental Hospital, Niigata City, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Hara","sequence":"additional","affiliation":[{"name":"Division of Paediatrics, Department of Homeostatic Regulation and Development, Niigata Graduate School of Medical and Dental Sciences, Niigata University Medical and Dental Hospital, Niigata City, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Uchiyama","sequence":"additional","affiliation":[{"name":"Division of Paediatrics, Department of Homeostatic Regulation and Development, Niigata Graduate School of Medical and Dental Sciences, Niigata University Medical and Dental Hospital, Niigata City, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,7,24]]},"reference":[{"key":"2022010711173396600_b1","first-page":"543","article-title":"Steroid\u2013sensitive idiopathic nephrotic syndrome in children","volume-title":"Pediatric Nephrology","author":"Niaudet","year":"2003","edition":"5th edn"},{"key":"2022010711173396600_b2","first-page":"341","article-title":"The child with idiopathic nephrotic syndrome","volume-title":"Clinical Paediatric Nephrology","author":"Haycock","year":"2003","edition":"3rd edn"},{"key":"2022010711173396600_b3","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/S0140-6736(74)91880-7","article-title":"Pathogenesis of lipoid nephrosis. a disorder of T-cell function","volume":"2","author":"Shalhoub","year":"1974","journal-title":"Lancet"},{"key":"2022010711173396600_b4","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1159\/000185325","article-title":"Studies of a glomerular permeability factor in patients with minimal\u2013change nephrotic syndrome","volume":"51","author":"Yoshizawa","year":"1989","journal-title":"Nephron"},{"key":"2022010711173396600_b5","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1159\/000185246","article-title":"Effect of supernatants derived from T lymphocyte culture in minimal change nephrotic syndrome on rat kidney capillaries","volume":"51","author":"Maruyama","year":"1989","journal-title":"Nephron"},{"key":"2022010711173396600_b6","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/ki.1991.232","article-title":"A glomerular permeability factor produced by human T cell hybridomas","volume":"40","author":"Koyama","year":"1991","journal-title":"Kidney Int"},{"key":"2022010711173396600_b7","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1007\/s004679900269","article-title":"Circulating mediators of proteinuria in idiopathic minimal lesion nephrotic syndrome","volume":"14","author":"Garin","year":"2000","journal-title":"Pediatr Nephrol"},{"key":"2022010711173396600_b8","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1093\/ndt\/gfh673","article-title":"Up-regulation of TRAIL mRNA expression in peripheral blood mononuclear cells from patients with minimal\u2013change nephrotic syndrome","volume":"20","author":"Okuyama","year":"2005","journal-title":"Nephrol Dial Transplant"},{"key":"2022010711173396600_b9","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1681\/ASN.V1351238","article-title":"A novel approach to investigation of the pathogenesis of active minimal\u2013change nephrotic syndrome using subtracted cDNA library screening","volume":"13","author":"Sahali","year":"2002","journal-title":"J Am Soc Nephrol"},{"key":"2022010711173396600_b10","first-page":"37","article-title":"A vascular permeability factor elaborated from lymphocytes. 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