{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T18:40:27Z","timestamp":1791139227094,"version":"4.1.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2005,12,20]],"date-time":"2005-12-20T00:00:00Z","timestamp":1135036800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,12,20]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Common variable immunodeficiency (CVID) is primary hypogammaglobulinaemia with an unknown aetiopathogenesis. Although various abnormalities of T and B cells have been described, their pathogenetic roles are unclear. We determined T and B lymphocyte subsets known to be abnormal in CVID in order to disclose possible relations between numerical abnormalities in those cells. Markers associated with B cell development (CD21, CD27, IgM, IgD) were determined on B lymphocytes (CD19+); T lymphocyte development (CD45RA, CD45RO, CD62L) and activation markers (CD25, CD27, CD28, CD29, CD38, CD57, HLA-DR) were determined on CD4+\u2003and CD8+\u2003T lymphocytes in 42 CVID patients and in 33 healthy controls. Abnormalities in CD4+\u2003T lymphocyte activation markers (increase in CD29, HLA-DR, CD45RO, decrease in CD27, CD62L, CD45RA) were observed particularly in patients with a decreased number of memory (CD27+) and mature (CD21+) B cells (group Ia according to the Freiburg group\u2019s classification), while abnormalities observed in CD8+ cells (increase in CD27 and CD28 and decrease in HLA-DR, CD57 and CD38) did not depend upon grouping patients together according to B lymphocyte developmental subpopulations. We observed correlations between immature B cells (IgM+\u2003CD21\u2013) and expression of CD27, CD62L, CD45RA, CD45RO and HLA-DR on CD4+ T cells in CVID patients but not in the control group. The expression of CD27 and CD45RA on CD4+\u2003T lymphocytes, such as the percentage of IgD+\u2003CD27\u2013 and IgD+\u2003CD27+ cells in B lymphocytes, showed age dependency to be more significant than in the control group. Our study demonstrates that T and B lymphocyte abnormalities in CVID are partially related to each other. Some of those abnormalities are not definite, but may evolve with age of the patient.<\/jats:p>","DOI":"10.1111\/j.1365-2249.2006.02999.x","type":"journal-article","created":{"date-parts":[[2005,12,20]],"date-time":"2005-12-20T16:32:25Z","timestamp":1135096345000},"page":"373-379","source":"Crossref","is-referenced-by-count":40,"title":["Age dependency and mutual relations in T and B lymphocyte abnormalities in common variable immunodeficiency patients"],"prefix":"10.1093","volume":"143","author":[{"given":"M","family":"Vlkov\u00e1","sequence":"first","affiliation":[{"name":"Department of Clinical Immunology and Allergology, St Anne\u2019s University Hospital, Masaryk University, Brno"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Thon","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology and Allergology, St Anne\u2019s University Hospital, Masaryk University, Brno"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"\u0160\u00e1rfyov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology and Allergology, St Anne\u2019s University Hospital, Masaryk University, Brno"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Bl\u00e1ha","sequence":"additional","affiliation":[{"name":"Faculty of Science, Masaryk University, Brno"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Svobodn\u00edk","sequence":"additional","affiliation":[{"name":"Faculty of Science, Masaryk University, Brno"},{"name":"Centre for Biostatistics and Analyses, Faculty of Medicine and Faculty of Science, Masaryk University, Brno, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Lokaj","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology and Allergology, St Anne\u2019s University Hospital, Masaryk University, Brno"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Litzman","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology and Allergology, St Anne\u2019s University Hospital, Masaryk University, Brno"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,12,20]]},"reference":[{"key":"2022010522205038700_b1","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1006\/clim.1999.4799","article-title":"Diagnostic criteria for primary immunodeficiencies","volume":"93","author":"Conley","year":"1999","journal-title":"Clin Immunol"},{"key":"2022010522205038700_b2","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1006\/clim.1999.4725","article-title":"Common variable immunodeficiency: clinical and immunological features of 248 patients","volume":"92","author":"Cunningham-Rundles","year":"1999","journal-title":"Clin 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