{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T14:54:06Z","timestamp":1772895246567,"version":"3.50.1"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2006,3,8]],"date-time":"2006-03-08T00:00:00Z","timestamp":1141776000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,3,27]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Inorganic mercury (Hg) in genetically susceptible mouse strains induces a T cell-dependent, systemic autoimmune condition (HgIA) characterized by immunostimulation, anti-nuclear antibodies (ANA) and systemic immune-complex (IC) deposits. The exact phenotypic expression of HgIA in different strains depends on H-2 and non-H-2 genes. Fc receptors (FcRs) are important in the development of many autoimmune diseases. In this study, the effect of targeted mutations for activating and inhibiting FcRs in the BALB\/c model of HgIA was examined. Hg-treated BALB\/c mice without mutation (wild-type, wt) showed heavy IC deposits in the renal glomerular mesangium, as well as in renal and splenic vessel walls. The renal mesangial IC deposits were severely reduced in Hg-treated BALB\/c mice without the \u03b3-chain (lack of the activating receptors Fc\u03b3RI, Fc\u03b3RIII and Fc\u2208RI), but unchanged in mice lacking the inhibitory Fc\u03b3RIIB. The Hg-induced vessel wall IC deposits present in wt mice were abolished and reduced in the FcR\u03b3 and Fc\u03b3RIIB strains, respectively. Hg-treated BALB\/c wt mice and mice without the \u03b3-chain showed an increase in serum IgE, while the increase in IgG1 was attenuated in the latter strain. In contrast, absence of the inhibiting Fc\u03b3RIIB augmented the Hg-induced increase of both serum IgG1 and IgE. In conclusion, FcRs are important mainly for the induction of systmeic IC deposits in the HgIA model, but also affects serum IgG1 and IgE levels.<\/jats:p>","DOI":"10.1111\/j.1365-2249.2006.03057.x","type":"journal-article","created":{"date-parts":[[2006,3,8]],"date-time":"2006-03-08T12:04:58Z","timestamp":1141819498000},"page":"309-318","source":"Crossref","is-referenced-by-count":14,"title":["The role of Fc-receptors in murine mercury-induced systemic autoimmunity"],"prefix":"10.1093","volume":"144","author":[{"given":"K","family":"Martinsson","sequence":"first","affiliation":[{"name":"Division of Molecular and Immunological Pathology (AIR), Department of Molecular and Clinical Medicine, Linkoping University, Linkoping, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Hultman","sequence":"additional","affiliation":[{"name":"Division of Molecular and Immunological Pathology (AIR), Department of Molecular and Clinical Medicine, Linkoping University, 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