{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T12:09:53Z","timestamp":1784635793533,"version":"3.55.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2006,4,21]],"date-time":"2006-04-21T00:00:00Z","timestamp":1145577600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,4,21]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Respiratory syncytial virus (RSV) is a common cause of lower respiratory tract disease (LRTD) in infants. Eosinophils have been suggested to play a role in the disease pathogenesis of LRTD. Inflammation can induce functional and morphological alterations of peripheral blood granulocytes. In patients with RSV LRTD, we aimed to investigate the eosinophil activation status by analysing surface markers. In vitro stimulation of eosinophils with cytokines leads to up-regulation of CD11b and priming markers recognized by the recently developed priming markers A17 and A27, whereas interleukin (IL)-5R\u03b1 is being down-regulated. In 51 patients and 10 controls we examined the expression of these surface markers on eosinophils in moderate to severe RSV-induced LRTD patients at the time of admission and 6\u2003weeks later during the convalescence phase. RSV-patients were characterized by a higher eosinophil CD11b expression compared to controls. Although basal A17 and A27 expression was not increased, we observed a significantly higher expression of these priming epitopes on N-formyl-methionyl-leucyl-phenylalanine (fMLP)-stimulated cells of RSV patients compared with cells of controls, indicative of prior in vivo priming. Furthermore, IL-5R\u03b1 expression was down-regulated on peripheral blood eosinophils of these patients. Follow-up blood samples showed normalization of all markers but CD11b, which was persistently increased. Utilizing cellular markers, we observed that peripheral blood eosinophils from infants with RSV LRTD are in a more activated state compared to eosinophils of controls, which normalizes only partially during convalescence.<\/jats:p>","DOI":"10.1111\/j.1365-2249.2006.03084.x","type":"journal-article","created":{"date-parts":[[2006,4,28]],"date-time":"2006-04-28T23:22:04Z","timestamp":1146266524000},"page":"409-417","source":"Crossref","is-referenced-by-count":40,"title":["Systemic eosinophil response induced by respiratory syncytial virus"],"prefix":"10.1093","volume":"144","author":[{"given":"C A","family":"Lindemans","sequence":"first","affiliation":[{"name":"Department of Pulmonary Diseases, University Medical Centre, Utrecht, the Netherlands, and"},{"name":"Department of Paediatrics, Wilhelmina Children\u2019s Hospital, Utrecht, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J L L","family":"Kimpen","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Wilhelmina Children\u2019s Hospital, Utrecht, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Luijk","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Diseases, University Medical Centre, Utrecht, the Netherlands, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Heidema","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Wilhelmina Children\u2019s Hospital, Utrecht, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Kanters","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Diseases, University Medical Centre, Utrecht, the Netherlands, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C K","family":"Van Der Ent","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Wilhelmina Children\u2019s Hospital, Utrecht, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Koenderman","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Diseases, University Medical Centre, Utrecht, the Netherlands, and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2006,4,28]]},"reference":[{"issue":"Suppl. 1","key":"2022010518593589000_b1","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1016\/S0264-410X(01)00301-2","article-title":"Immunopathogenesis of vaccine-enhanced RSV disease","volume":"20","author":"Openshaw","year":"2001","journal-title":"Vaccine"},{"key":"2022010518593589000_b2","doi-asserted-by":"crossref","first-page":"S59","DOI":"10.1164\/ajrccm\/152.4_Pt_2.S59","article-title":"Immunity and immunopathology to respiratory syncytial virus. 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