{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T10:10:46Z","timestamp":1789467046521,"version":"build-2803163510"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2006,6,23]],"date-time":"2006-06-23T00:00:00Z","timestamp":1151020800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,6,23]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The objective of this work was to study the role of mannose-binding lectin (MBL) and C-reactive protein (CRP) in pneumococcal pneumonia, to determine whether MBL acts as an acute-phase reactant and whether the severity of the disease correlates with MBL levels. The study comprised 100 patients with pneumococcal pneumonia. The pneumonia severity score was calculated and graded into a risk class of mortality (Fine scale). The MBL genotypes and the levels of MBL and CRP at the acute and recovery phases were determined. Fifty patients with the wild-type MBL genotype showed higher MBL levels in each phase (P\u2003&amp;lt;\u20030\u00b7001) and an increased risk to developing bacteraemia, odds ratio (OR) 2\u00b774, 95% confidence interval (CI) 1\u00b701\u20137\u00b752) (P = 0\u00b702), but this did not correlate with the pneumonia severity class. CRP levels in the acute phase, 79\u00b753 mg\/l [standard deviation (s.d.) 106\u00b793], were higher in the subjects with positive blood cultures (P = 0\u00b7003), and remained higher [20\u00b712 mg\/l (s.d. 31\u00b790)] in the group of patients with an underlying disease (P = 0\u00b701). No correlation was observed between the levels of MBL and CRP in each phase, or with the pneumonia severity score. We cannot conclude that MBL acts uniformly as an acute-phase reactant in pneumococcal pneumonia. MBL levels do not correlate well with the severity of the pneumonia. The risk of developing bacteraemia could be enhanced in individuals with the wild-type MBL genotype.<\/jats:p>","DOI":"10.1111\/j.1365-2249.2006.03140.x","type":"journal-article","created":{"date-parts":[[2006,6,23]],"date-time":"2006-06-23T14:41:02Z","timestamp":1151073662000},"page":"228-234","source":"Crossref","is-referenced-by-count":36,"title":["Mannose-binding lectin does not act as an acute-phase reactant in adults with community-acquired pneumococcal pneumonia"],"prefix":"10.1093","volume":"145","author":[{"given":"M","family":"Perez-Castellano","sequence":"first","affiliation":[{"name":"Service of Immunology, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Pe\u00f1aranda","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit Hospital Son Dureta, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Payeras","sequence":"additional","affiliation":[{"name":"Internal Medicine Service, Hospital Son Ll\u00e0tzer, Palma de Mallorca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Mil\u00e0","sequence":"additional","affiliation":[{"name":"Service of Immunology, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Riera","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit Hospital Son Dureta, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Vidal","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit Hospital Son Dureta, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Pujalte","sequence":"additional","affiliation":[{"name":"Service of Immunology, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Pareja","sequence":"additional","affiliation":[{"name":"Internal Medicine Service, Hospital Son Ll\u00e0tzer, Palma de Mallorca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Villalonga","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit Hospital Son Dureta, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Matamoros","sequence":"additional","affiliation":[{"name":"Service of Immunology, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2006,6,23]]},"reference":[{"key":"2022010506233627800_b1","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1034\/j.1399-3003.2000.15d21.x","article-title":"Epidemiology of community-acquired pneumonia in adults: a population based study","volume":"15","author":"Almirall","year":"2000","journal-title":"Eur Resp J"},{"key":"2022010506233627800_b2","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1002\/hep.1840120517","article-title":"Acute-phase response of human hepatocytes: regulation of acute-phase protein synthesis by interleukin-6","volume":"12","author":"Castell","year":"1990","journal-title":"Hepatology"},{"key":"2022010506233627800_b3","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/BF02786357","article-title":"C-reactive protein: structural biology, gene expression and host defense function","volume":"16","author":"Szalai","year":"1997","journal-title":"Immunol Res"},{"key":"2022010506233627800_b4","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.4049\/jimmunol.112.6.2135","article-title":"Interaction of C-reactive protein complexes with the complement system. 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