{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T02:30:22Z","timestamp":1772850622635,"version":"3.50.1"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2006,6,23]],"date-time":"2006-06-23T00:00:00Z","timestamp":1151020800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,6,23]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Autoantibodies against C1q have been described in many immune-complex diseases including hypocomplementaemic urticarial vasculitis and systemic lupus erythematosus (SLE). No study has focused on the role of anti-C1q antibodies in hepatitis C virus (HCV) infection. The aim of this study was (i) to evaluate the prevalence of anti-C1q antibodies in HCV infection; and (ii) to analyse the association of anti-C1q antibodies with clinical and biological features of HCV\u2013mixed cryoglobulinaemia (MC) vasculitis. We searched for anti-C1q antibodies using an enzyme-linked immunosorbent assay (ELISA) test in 111 HCV patients (75 had cryoglobulin and 23 systemic vasculitis), 60 SLE patients and 109 blood donors. Anti-C1q antibodies were detected in 26% of HCV patients compared to 10% of healthy donors (P\u2003&amp;lt;\u20030\u00b701), and 38% in patients with SLE. Although there was a higher prevalence of anti-C1q antibodies among HCV patients with type III cryoglobulin (50%, P\u2003&amp;lt;\u20030\u00b701), the overall prevalence of anti-C1q antibodies was similar in HCV patients being cryoglobulin-positive or cryoglobulin-negative (26%versus 25%, P = 0\u00b798). A significant association was found between anti-C1q antibodies and low C4 fraction of complement (P\u2003&amp;lt;\u20030\u00b705). No association was found between anti-C1q antibodies and HCV genotype, severity of liver disease or with specific clinical signs of HCV\u2013MC vasculitis. This study shows an increased prevalence of anti-C1q antibodies in HCV-infected patients. Anti-C1q antibodies were associated with low C4 levels. No association was found between anti-C1q antibodies and HCV\u2013MC vasculitis, nor between anti-C1q antibodies and cryoglobulinaemia.<\/jats:p>","DOI":"10.1111\/j.1365-2249.2006.03153.x","type":"journal-article","created":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T07:51:18Z","timestamp":1152604278000},"page":"308-312","source":"Crossref","is-referenced-by-count":38,"title":["Anti-C1q antibodies in hepatitis C virus infection"],"prefix":"10.1093","volume":"145","author":[{"given":"D","family":"Saadoun","sequence":"first","affiliation":[{"name":"Service de M\u00e9decine Interne, France"},{"name":"CNRS UMR 7087, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Sadallah","sequence":"additional","affiliation":[{"name":"Department of Research, Universitatsspital, Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Trendelenburg","sequence":"additional","affiliation":[{"name":"Department of Research, Universitatsspital, Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Limal","sequence":"additional","affiliation":[{"name":"CNRS UMR 7087, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Sene","sequence":"additional","affiliation":[{"name":"CNRS UMR 7087, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J C","family":"Piette","sequence":"additional","affiliation":[{"name":"CNRS UMR 7087, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J A","family":"Schifferli","sequence":"additional","affiliation":[{"name":"Department of Research, Universitatsspital, Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Cacoub","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Interne, France"},{"name":"CNRS UMR 7087, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"2022010506234103400_b1","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0002-9343(80)90390-3","article-title":"Mixed cryoglobulinemia: clinical aspects and long-term follow-up of 40 patients","volume":"69","author":"Gorevic","year":"1980","journal-title":"Am J Med"},{"key":"2022010506234103400_b2","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1097\/00005792-200001000-00005","article-title":"Extrahepatic manifestations associated with hepatitis C virus infection. 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