{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:49:34Z","timestamp":1790873374049,"version":"4.1.0"},"reference-count":62,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2006,7,12]],"date-time":"2006-07-12T00:00:00Z","timestamp":1152662400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,7,12]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Chronic periodontitis is correlated with Porphyromonas gingivalis infection. In this study, we found that the expression of secretory leucocyte protease inhibitor (SLPI), an endogenous inhibitor for neutrophil-derived proteases, was reduced in gingival tissues with chronic periodontitis associated with P. gingivalis infection. The addition of vesicles of P. gingivalis decreased the amount of SLPI in the media of primary human gingival keratinocytes compared to untreated cultures. We therefore investigated how arginine-specific gingipains (Rgps) affect the functions of SLPI, because Rgps are the major virulence factors in the vesicles and cleave a wide range of in-host proteins. We found that Rgps digest SLPI in vitro, suppressing the release of SLPI. Rgps proteolysis of SLPI disrupted SLPI functions, which normally suppresses neutrophil elastase and neutralizes pro-inflammatory effects of bacterial cell wall compounds in cultured human gingival fibroblasts. The protease inhibitory action of SLPI was not exerted towards Rgps. These results suggest that Rgps reduce the protective effects of SLPI on neutrophil proteases and bacterial proinflammatory compounds, by which disease in gingival tissue may be accelerated at the sites with P. gingivalis infection.<\/jats:p>","DOI":"10.1111\/j.1365-2249.2006.03156.x","type":"journal-article","created":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T20:14:16Z","timestamp":1153253656000},"page":"545-554","source":"Crossref","is-referenced-by-count":43,"title":["Arginine-specific gingipains from <i>Porphyromonas gingivalis<\/i> deprive protective functions of secretory leucocyte protease inhibitor in periodontal tissue"],"prefix":"10.1093","volume":"145","author":[{"given":"T","family":"Into","sequence":"first","affiliation":[{"name":"Department of Oral Disease Research, National Institute for Longevity Sciences, Obu, Aichi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Inomata","sequence":"additional","affiliation":[{"name":"Department of Oral Disease Research, National Institute for Longevity Sciences, Obu, Aichi, Japan"},{"name":"Department of Periodontology, School of Dentistry, Aichigakuin University, Nagoya, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Kanno","sequence":"additional","affiliation":[{"name":"Department of Oral Disease Research, National Institute for Longevity Sciences, Obu, Aichi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Matsuyama","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Machigashira","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Izumi","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Imamura","sequence":"additional","affiliation":[{"name":"Division of Molecular Pathology, Department of Neuroscience and Immunology, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Nakashima","sequence":"additional","affiliation":[{"name":"Department of Oral Disease Research, National Institute for Longevity Sciences, Obu, Aichi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Noguchi","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of Dentistry, Aichigakuin University, Nagoya, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Matsushita","sequence":"additional","affiliation":[{"name":"Department of Oral Disease Research, National Institute for Longevity Sciences, Obu, Aichi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"2022010506233173000_b1","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1902\/jop.1992.63.4s.338","article-title":"Host responses in periodontal diseases: current concepts","volume":"63","author":"Genco","year":"1992","journal-title":"J 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