{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T15:46:24Z","timestamp":1774712784129,"version":"3.50.1"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2006,8,8]],"date-time":"2006-08-08T00:00:00Z","timestamp":1154995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,8,25]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>In small bowel transplantation (SBTx), graft-versus-host disease (GVHD) is mediated by donor-derived T cells recognizing host major histocompatibility complex (MHC) alloantigens, and represents an important immunological event influencing life in experimental and clinical situations. We evaluated the possibility that a new sphingosine 1-phosphate receptor agonist, FTY720, could diminish GVHD in a rat SBTx model through traffic alteration of donor-derived T cells in target organs. Heterotopic SBTx was performed using a parent (WF)-into-F1 (WF\u2003\u00d7\u2003ACI) rat combination. Recipient survival, body weight, histopathology, donor-derived T cell subpopulation and cytokine production were compared with untreated controls. FTY720 inhibited lethality and histopathological changes in target organs when administered at 0\u00b75 mg\/kg, possibly due to sequestration of donor-derived T cells in the intestinal graft. FTY720 caused a significant reduction in donor T cell numbers in target organs by promoting these cells to home into donor, but not recipient, secondary lymphoid tissues. FTY720 significantly decreased production of interferon (IFN)-\u03b3 in target organs. These findings indicate that FTY720 effectively reduced recirculation of activated donor-derived T cells and recruitment to target organs in GVHD, and was also associated with down-regulated IFN-\u03b3 production. These properties may offer the potential to treat ongoing GVHD in SBTx.<\/jats:p>","DOI":"10.1111\/j.1365-2249.2006.03175.x","type":"journal-article","created":{"date-parts":[[2006,8,8]],"date-time":"2006-08-08T18:45:39Z","timestamp":1155062739000},"page":"85-92","source":"Crossref","is-referenced-by-count":14,"title":["Inhibition of donor-derived T cells trafficking into target organs by FTY720 during acute graft-<i>versus<\/i>-host disease in small bowel transplantation"],"prefix":"10.1093","volume":"146","author":[{"given":"J","family":"Song","sequence":"first","affiliation":[{"name":"Department of Surgery (E1), Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Surgery (E1), Japan"},{"name":"Department of Complementary and Alternative Medicine, Osaka University Graduate School of Medicine, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Department of Surgery (E1), Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Miao","sequence":"additional","affiliation":[{"name":"Department of Surgery (E1), Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Tanemura","sequence":"additional","affiliation":[{"name":"Department of Surgery (E1), Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Nishida","sequence":"additional","affiliation":[{"name":"Department of Surgery (E1), Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Nozawa","sequence":"additional","affiliation":[{"name":"Department of Surgery (E1), Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Department of Surgery (E1), Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Sawa","sequence":"additional","affiliation":[{"name":"Department of Surgery (E1), Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2006,8,8]]},"reference":[{"key":"2022010503195700600_b1","doi-asserted-by":"crossref","first-page":"S75","DOI":"10.1097\/01.TP.0000126931.23349.15","article-title":"Advances in small-intestine transplantation","volume":"77","author":"Langnas","year":"2004","journal-title":"Transplantation"},{"key":"2022010503195700600_b2","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.1600-065X.1985.tb01159.x","article-title":"Graft-versus-host disease","volume":"88","author":"Gale","year":"1985","journal-title":"Immunol Rev"},{"key":"2022010503195700600_b3","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1111\/j.1600-6143.2004.00524.x","article-title":"Graft versus host disease in intestinal transplantation","volume":"4","author":"Mazariegos","year":"2004","journal-title":"Am J Transplant"},{"key":"2022010503195700600_b4","doi-asserted-by":"crossref","first-page":"265","DOI":"10.4049\/jimmunol.150.1.265","article-title":"Nonmitogenic anti-CD3F(ab\u2032)2 fragments inhibit lethal murine graft-versus-host disease induced across the major histocompatibility barrier","volume":"150","author":"Blazar","year":"1993","journal-title":"J Immunol"},{"key":"2022010503195700600_b5","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.4049\/jimmunol.155.5.2396","article-title":"Kinetics of Th1 and Th2 cytokine production during the early course of acute and chronic murine graft-versus-host disease. 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