{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T11:47:08Z","timestamp":1791460028794,"version":"4.3.4"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2006,8,25]],"date-time":"2006-08-25T00:00:00Z","timestamp":1156464000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,8,25]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Understanding of the aetiological basis of thyroid autoimmunity may be gained by studying the early stages of the disease process. We aimed to (1) investigate the relationship between thyroid antibody status and Yersinia enterocolitica (YE) infection in euthyroid subjects and (2) explore the relative importance of genetic and environmental risk factors in the acquisition of YE infection. The association between thyroid antibody status and YE infection was explored using a case\u2013control design. Furthermore, thyroid antibody-positive twins were compared with their thyroid antibody-negative co-twin. In 468 twins, IgA and IgG antibodies to virulence-associated outer-membrane proteins (YOPs) of YE were measured. Of these, 147 were thyroid antibody-positive (cases). A total of 147 age- and gender-matched twins were chosen as controls. The prevalence of YOP antibodies was lower among thyroid antibody-positive individuals than among controls. Yersinia infection was not associated with a positive thyroid antibody status: the odds ratio (with 95% CI) for YOP IgA-ab was 0\u00b766 (0\u00b742\u20131\u00b705), P\u2003=\u20030\u00b7078 and for YOP IgG-ab it was 0\u00b795 (0\u00b760\u20131\u00b750), P\u2003=\u20030\u00b7816. Within discordant twin pairs, the thyroid antibody-positive twin did not have an increased risk of Yersinia infection compared to the thyroid antibody-negative co-twin [odds ratio: YOP IgA-Ab: 0\u00b794 (0\u00b749\u20131\u00b783), P\u2003=\u20030\u00b7866, and YOP IgG-Ab: 1\u00b735 (0\u00b772\u20132\u00b753), P\u2003=\u20030\u00b7345]; 41% (95% CI 10\u201367% of the liability of being YOP antibody-positive was due to genetic effects. In conclusion, Yersinia infection does not confer an increased risk of thyroid antibodies. The genetic contribution in the acquisition of Yersinia infection is modest.<\/jats:p>","DOI":"10.1111\/j.1365-2249.2006.03183.x","type":"journal-article","created":{"date-parts":[[2006,8,30]],"date-time":"2006-08-30T08:28:52Z","timestamp":1156926532000},"page":"32-38","source":"Crossref","is-referenced-by-count":27,"title":["<i>Yersinia enterocolitica<\/i> infection does not confer an increased risk of thyroid antibodies: evidence from a Danish twin study"],"prefix":"10.1093","volume":"146","author":[{"given":"P S","family":"Hansen","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark"},{"name":"The Danish Twin Registry, Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B E","family":"Wenzel","sequence":"additional","affiliation":[{"name":"Cell and Immunbiological Laboratory, Department of Medicine I, Medical University L\u00fcbeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T H","family":"Brix","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Heged\u00fcs","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2006,8,30]]},"reference":[{"key":"2022010503195333300_b1","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/S0140-6736(74)91152-0","article-title":"Yersinia enterocolitica infection and thyroid 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