{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T19:11:02Z","timestamp":1683573062118},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2006,8,25]],"date-time":"2006-08-25T00:00:00Z","timestamp":1156464000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,8,25]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Mice of I\/St strain develop severe lung inflammation and die shortly following infection with virulent mycobacteria. To find out whether tuberculosis (TB)-susceptible I\/St mice are susceptible to other intracellular bacteria, we investigated two different taxonomically distant pathogens, Chlamydia pneumoniae and Salmonella enterica serovar Typhimurium. Comparison of I\/St and TB-resistant A\/Sn mice (both Nramp1r) demonstrated that the former are more susceptible to both salmonella and chlamydia, displaying a significantly shortened survival time following challenge. Lung pathology develops more rapidly in I\/St compared to A\/Sn mice following infection with chlamydia, despite their similar ability to control bacterial multiplication. Following infection with salmonella, substantial (\u223c\u20033 log) but very short (second day post-infection) interstrain differences in bacterial loads were observed, accompanied by higher levels of interleukin (IL)-6 and tumour necrosis factor (TNF)-\u03b1 in the peritoneal cavities of I\/St mice. I\/St macrophages were more permissive for salmonella growth during the first 24 h following infection in vitro. Because the prominent differences in survival time did not correlate with permanent differences in bacterial multiplication, we suggest that both infections trigger fatal pathological processes whose dynamics depend strongly upon the host genetics.<\/jats:p>","DOI":"10.1111\/j.1365-2249.2006.03184.x","type":"journal-article","created":{"date-parts":[[2006,8,31]],"date-time":"2006-08-31T09:44:59Z","timestamp":1157017499000},"page":"93-100","source":"Crossref","is-referenced-by-count":6,"title":["<i>Mycobacterium tuberculosis<\/i>-susceptible I\/St mice develop severe disease following infection with taxonomically distant bacteria,<i>Salmonella enterica<\/i>and<i>Chlamydia pneumoniae<\/i>"],"prefix":"10.1093","volume":"146","author":[{"given":"L N","family":"Nesterenko","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology, Gamaleya Research Institute for Epidemiology and Microbiology, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D V","family":"Balunets","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Gamaleya Research Institute for Epidemiology and Microbiology, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A S","family":"Tomova","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Gamaleya Research Institute for Epidemiology and Microbiology, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J M","family":"Romanova","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Gamaleya Research Institute for Epidemiology and Microbiology, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J S","family":"Alyapkina","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Gamaleya Research Institute for Epidemiology and Microbiology, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N A","family":"Zigangirova","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Gamaleya Research Institute for Epidemiology and Microbiology, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M A","family":"Kapina","sequence":"additional","affiliation":[{"name":"Laboratory for Immunogenetics, Central Research Institute for Tuberculosis, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E V","family":"Kondratieva","sequence":"additional","affiliation":[{"name":"Laboratory for Immunogenetics, Central Research Institute for Tuberculosis, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A V","family":"Pichugin","sequence":"additional","affiliation":[{"name":"Laboratory for Immunogenetics, Central Research Institute for Tuberculosis, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K B","family":"Majorov","sequence":"additional","affiliation":[{"name":"Laboratory for Immunogenetics, Central Research Institute for Tuberculosis, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A S","family":"Apt","sequence":"additional","affiliation":[{"name":"Laboratory for Immunogenetics, Central Research Institute for Tuberculosis, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2006,8,31]]},"reference":[{"key":"2022010503195799000_b1","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s003350040001","article-title":"The battle of two genomes: genetics of bacterial host\/pathogen interactions in mice","volume":"12","author":"Lengeling","year":"2001","journal-title":"Mammal 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