{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T19:51:16Z","timestamp":1787946676438,"version":"build-2784847793"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2006,9,27]],"date-time":"2006-09-27T00:00:00Z","timestamp":1159315200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,9,27]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>We show that at least half of patients with common variable immunodeficiency (CVID) have circulating CD8+ T cells specific for epitopes derived from cytomegalovirus (CMV) and\/or the Epstein\u2013Barr virus (EBV). Compared to healthy age-matched subjects, more CD8+ T cells in CVID patients were committed to CMV. Despite previous reports of defects in antigen presentation and cellular immunity in CVID, specific CD4+ and CD8+ T cells produced interferon (IFN)-\u03b3 after stimulation with CMV peptides, and peripheral blood mononuclear cells secreted perforin in response to these antigens. In CVID patients we found an association between a high percentage of circulating CD8+\u2003CD57+ T cells containing perforin, CMV infection and a low CD4\/CD8 ratio, suggesting that CMV may have a major role in the T cell abnormalities described previously in this disease. We also show preliminary evidence that CMV contributes to the previously unexplained severe enteropathy that occurs in about 5% of patients.<\/jats:p>","DOI":"10.1111\/j.1365-2249.2006.03209.x","type":"journal-article","created":{"date-parts":[[2006,9,27]],"date-time":"2006-09-27T09:42:55Z","timestamp":1159350175000},"page":"234-242","source":"Crossref","is-referenced-by-count":59,"title":["The T cell response to persistent herpes virus infections in common variable immunodeficiency"],"prefix":"10.1093","volume":"146","author":[{"given":"M","family":"Raeiszadeh","sequence":"first","affiliation":[{"name":"Centre for Immunology, Hampstead Campus, Royal Free and University College Medical School, London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Kopycinski","sequence":"additional","affiliation":[{"name":"Department of Infection, Hampstead Campus, Royal Free and University College Medical School, London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S J","family":"Paston","sequence":"additional","affiliation":[{"name":"Centre for Immunology, Hampstead Campus, Royal Free and University College Medical School, London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Diss","sequence":"additional","affiliation":[{"name":"Department of Histopathology, UCL Hospitals NHS Trust, London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Lowdell","sequence":"additional","affiliation":[{"name":"Department of Haematology, Royal Free Hampstead NHS Trust, London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G A D","family":"Hardy","sequence":"additional","affiliation":[{"name":"Centre for Immunology, Hampstead Campus, Royal Free and University College Medical School, London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A D","family":"Hislop","sequence":"additional","affiliation":[{"name":"Institute for Cancer Studies and MRC Centre for Immune Regulation, University of Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Workman","sequence":"additional","affiliation":[{"name":"Centre for Immunology, Hampstead Campus, Royal Free and University College Medical School, London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Dodi","sequence":"additional","affiliation":[{"name":"Anthony Nolan Centre, Pond Street, London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Emery","sequence":"additional","affiliation":[{"name":"Department of Infection, Hampstead Campus, Royal Free and University College Medical School, London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A D","family":"Webster","sequence":"additional","affiliation":[{"name":"Centre for Immunology, Hampstead Campus, Royal Free and University College Medical School, London"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2006,9,27]]},"reference":[{"key":"2022010503194037400_b1","first-page":"31","article-title":"Primary hypogammaglobulinaemia: a survey of clinical manifestations and complications","volume":"86","author":"Hermaszewski","year":"1993","journal-title":"Q J Med"},{"key":"2022010503194037400_b2","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1006\/clim.1999.4725","article-title":"Common variable immunodeficiency: clinical and immunological features of 248 patients","volume":"92","author":"Cunningham-Rundles","year":"1999","journal-title":"Clin Immunol"},{"key":"2022010503194037400_b3","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0090-1229(86)90070-X","article-title":"Infectious complications of the primary immunodeficiencies","volume":"40","author":"Stiehm","year":"1986","journal-title":"Clin Immunol Immunopathol"},{"key":"2022010503194037400_b4","first-page":"1","article-title":"Common variable immunodeficiency","volume-title":"Humoral immunodeficiences. 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