{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T06:57:33Z","timestamp":1771657053242,"version":"3.50.1"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2006,9,27]],"date-time":"2006-09-27T00:00:00Z","timestamp":1159315200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,9,27]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Interferon (IFN)-\u03b1 induced CD4+ T lymphopenia is a toxic effect of the treatment of chronic hepatitis C virus (HCV) in human immunodeficiency virus (HIV)-co-infected patients. To increase the knowledge about this secondary effect, we performed an analysis of the evolution of the T cell receptor excision circles (TRECs), CD4+ and CD8+ T cells and of their CD45RO+ and CD45RA+ subpopulations during the treatment of chronic hepatitis HCV with peginterferon alpha (pegIFN-\u03b1)\u2003+\u2003ribavirin. Twenty HCV\/HIV-co-infected patients, with undetectable HIV load after highly active antiretroviral therapy (HAART), were treated with pegIFN-\u03b1\u2003+\u2003ribavirin. TRECs were determined using real-time polymerase chain reaction. CD4+ and CD8+ T cells and their CD45RO+ and CD45RA+ subpopulations were analysed by two-colour flow cytometry. Median baseline CD4+ and CD8+ T cells were 592\u2003mm3 and 874\u2003mm3, respectively. Median baseline CD45RO+ subpopulation was 48% for CD4+ T and 57% for CD8+ T lymphocytes. A progressive decrease in both T cell populations, as well as of their CD45RO+ and CD45RA+ subpopulations, was detected, with a difference between the baseline and nadir levels approaching 50%. The evolution of T cell populations and TRECs was independent of the response to the treatment. T lymphocytes and their subpopulations returned to baseline levels at 24 weeks after the end of treatment, with the exception of the T CD4+ CD45RA+ subpopulation. The ratio of CD4+ CD45RO+\/CD4+ CD45RA+ increased from 0\u00b789 (baseline) to 1\u00b744 (24 weeks after the end of the therapy). TRECs\/ml did not return to the basal values. In conclusion, a significant reduction of CD4+ and CD8+ T cells, and of their CD45RA+ and CD45RO+ subpopulations, in HIV\/HCV co-infected patients treated with pegIFN-\u03b1 was observed. Both subpopulations increased after the suppression of treatment, but the CD4+ CD45RA subpopulation did not reach the basal levels as a consequence, at least in part, of a decrease in thymic production.<\/jats:p>","DOI":"10.1111\/j.1365-2249.2006.03220.x","type":"journal-article","created":{"date-parts":[[2006,9,29]],"date-time":"2006-09-29T13:06:33Z","timestamp":1159535193000},"page":"270-277","source":"Crossref","is-referenced-by-count":14,"title":["T cell receptor excision circles (TRECs), CD4+, CD8+ and their CD45RO+ and CD45RA+ subpopulations in hepatitis C virus (HCV)-HIV-co-infected patients during treatment with interferon alpha plus ribavirin: analysis in a population on effective antiretroviral therapy"],"prefix":"10.1093","volume":"146","author":[{"given":"A","family":"Arizcorreta","sequence":"first","affiliation":[{"name":"Servicios de Medicina Interna"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"M\u00e1rquez","sequence":"additional","affiliation":[{"name":"Servicios de Medicina Interna"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Fern\u00e1ndez-Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Microbiolog\u00eda, Hospital Universitario Puerta del Mar, C\u00e1diz, Spain, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E P\u00e9rez","family":"Guzm\u00e1n","sequence":"additional","affiliation":[{"name":"Servicios de Medicina Interna"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Brun","sequence":"additional","affiliation":[{"name":"Servicios de Medicina Interna"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Rodr\u00edguez-Iglesias","sequence":"additional","affiliation":[{"name":"Servicio de Microbiolog\u00eda, Hospital Universitario Puerto Real, C\u00e1diz, 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