{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T16:48:37Z","timestamp":1778604517590,"version":"3.51.4"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2006,10,13]],"date-time":"2006-10-13T00:00:00Z","timestamp":1160697600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,10,13]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>CD45, the leucocyte common antigen, is a haematopoietic cell specific tyrosine phosphatase. Human polymorphic CD45 variants are associated with autoimmune and infectious diseases and alter the phenotype and function of lymphocytes, establishing CD45 as an important regulator of immune function. Here we report four patients with diverse diseases with unusual clinical features. All four have the C77G polymorphism of CD45 exon 4, which alters the splicing and CD45RA\/CD45R0 phenotype of lymphocytes. We suggest that C77G may be a contributing factor in these unusual cases.<\/jats:p>","DOI":"10.1111\/j.1365-2249.2006.03230.x","type":"journal-article","created":{"date-parts":[[2006,10,26]],"date-time":"2006-10-26T12:59:41Z","timestamp":1161867581000},"page":"448-454","source":"Crossref","is-referenced-by-count":16,"title":["Unusual case presentations associated with the CD45 C77G polymorphism"],"prefix":"10.1093","volume":"146","author":[{"given":"E\u2003Z","family":"Tchilian","sequence":"first","affiliation":[{"name":"The Edward Jenner Institute for Vaccine Research, Compton, Berkshire, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Gil","sequence":"additional","affiliation":[{"name":"Servicio de Inmunolog\u00eda, Hospital General Universitario \u2018Gregorio Mara\u00f1\u00f3n\u2019, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u2003L","family":"Navarro","sequence":"additional","affiliation":[{"name":"Servicio de 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Oxford Radcliffe Hospital, Oxford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Renz","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry and Molecular Diagnostics, University Hospital, Philipps-University, Marburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Schwinzer","sequence":"additional","affiliation":[{"name":"Transplantation Laboratory, Department of Visceral and Transplantation Surgery, Hannover Medical School, Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u2003C\u2003L","family":"Beverley","sequence":"additional","affiliation":[{"name":"The Edward Jenner Institute for Vaccine Research, Compton, Berkshire, 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