{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T06:06:50Z","timestamp":1793426810594,"version":"4.5.0"},"reference-count":71,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2006,11,27]],"date-time":"2006-11-27T00:00:00Z","timestamp":1164585600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,1,5]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Inflammation is part of the non-specific immune response that occurs in reaction to any type of bodily injury. In some disorders, the inflammatory process\u2003\u2212\u2003which under normal conditions is self-limiting\u2003\u2212\u2003becomes continuous and chronic inflammatory diseases might develop subsequently. Pattern recognition molecules (PRMs) represent a diverse collection of molecules responsible for sensing danger signals, and together with other immune components they are involved in the first line of defence. NALP3 and NOD2, which belong to a cytosolic subgroup of PRMs, dubbed Nod-like-receptors (NLRs), have been associated recently with inflammatory diseases, specifically Crohn's disease and Blau syndrome (NOD2) and familial cold autoinflammatory syndrome, Muckle\u2013Wells syndrome and chronic infantile neurological cutaneous and articular syndrome (NALP3). The exact effects of the defective proteins are not fully understood, but activation of nuclear factor (NF)-\u03baB, transcription, production and secretion of interleukin (IL)-1\u03b2 and activation of the inflammasome are some of the processes that might hold clues, and the present review will provide a thorough update in this area.<\/jats:p>","DOI":"10.1111\/j.1365-2249.2006.03261.x","type":"journal-article","created":{"date-parts":[[2006,11,27]],"date-time":"2006-11-27T04:59:02Z","timestamp":1164603542000},"page":"227-235","source":"Crossref","is-referenced-by-count":898,"title":["Chronic inflammation: importance of NOD2 and NALP3 in interleukin-1\u03b2 generation"],"prefix":"10.1093","volume":"147","author":[{"given":"L","family":"Ferrero-Miliani","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Herlev Hospital, University of Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O H","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Herlev Hospital, University of Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P S","family":"Andersen","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology, Department of Clinical Biochemistry, State Serum Institute, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S E","family":"Girardin","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathobiology, University of Toronto, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2006,11,27]]},"reference":[{"key":"2022010415134214000_b1","volume-title":"De medicina","author":"Celsus","year":"1935"},{"key":"2022010415134214000_b2","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1177\/09680519050110060301","article-title":"How Toll-like receptors and Nod-like receptors contribute to innate immunity in mammals","volume":"11","author":"Fritz","year":"2005","journal-title":"J Endotoxin Res"},{"key":"2022010415134214000_b3","first-page":"81","article-title":"Toll-like receptors and their ligands","volume":"270","author":"Barton","year":"2002","journal-title":"Curr Top Microbiol Immunol"},{"key":"2022010415134214000_b4","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.it.2005.06.004","article-title":"NLRs join TLRs as innate sensors of pathogens","volume":"26","author":"Martinon","year":"2005","journal-title":"Trends Immunol"},{"key":"2022010415134214000_b5","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/S0959-440X(01)00266-4","article-title":"The leucine-rich repeat as a protein recognition motif","volume":"11","author":"Kobe","year":"2001","journal-title":"Curr Opin Struct Biol"},{"key":"2022010415134214000_b6","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0968-0004(00)01577-2","article-title":"The NACHT family\u2003\u2212\u2003a new group of predicted NTPases implicated in apoptosis and MHC transcription activation","volume":"25","author":"Koonin","year":"2000","journal-title":"Trends Biochem Sci"},{"key":"2022010415134214000_b7","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1042\/BJ20031506","article-title":"Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses","volume":"381","author":"Damiano","year":"2004","journal-title":"Biochem J"},{"key":"2022010415134214000_b8","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/j.crvi.2004.08.006","article-title":"Fire and death: the pyrin domain joins the death-domain superfamily","volume":"327","author":"Kohl","year":"2004","journal-title":"C R Biol"},{"key":"2022010415134214000_b9","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1083\/jcb.200509092","article-title":"Caspases leave the beaten track: caspase-mediated activation of NF-kappaB","volume":"173","author":"Lamkanfi","year":"2006","journal-title":"J Cell Biol"},{"key":"2022010415134214000_b10","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1084\/jem.20032234","article-title":"The PYRIN connection: novel players in innate immunity and inflammation","volume":"200","author":"Stehlik","year":"2004","journal-title":"J Exp Med"},{"key":"2022010415134214000_b11","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0083-6729(04)67008-7","article-title":"CARDINAL roles in apoptosis and NFkappaB activation","volume":"67","author":"Bouchier-Hayes","year":"2004","journal-title":"Vitam Horm"},{"key":"2022010415134214000_b12","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1006\/bbrc.2000.4190","article-title":"Pyrin N-terminal homology domain- and caspase recruitment domain-dependent oligomerization of ASC","volume":"280","author":"Masumoto","year":"2001","journal-title":"Biochem Biophys Res Commun"},{"key":"2022010415134214000_b13","doi-asserted-by":"crossref","first-page":"3009","DOI":"10.1186\/gb-2001-2-7-reviews3009","article-title":"Inhibitor of apoptosis proteins and their relatives: IAPs and other BIRPs","volume":"2","author":"Verhagen","year":"2001","journal-title":"Genome Biol"},{"key":"2022010415134214000_b14","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0016-5085(03)00661-9","article-title":"Crohn's disease and the NOD2 gene: a role for paneth cells","volume":"125","author":"Lala","year":"2003","journal-title":"Gastroenterology"},{"key":"2022010415134214000_b15","doi-asserted-by":"crossref","first-page":"4812","DOI":"10.1074\/jbc.M008072200","article-title":"Nod2, a Nod1\/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB","volume":"276","author":"Ogura","year":"2001","journal-title":"J Biol Chem"},{"key":"2022010415134214000_b16","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1136\/gut.52.11.1591","article-title":"Expression of NOD2 in Paneth cells: a possible link to Crohn's ileitis","volume":"52","author":"Ogura","year":"2003","journal-title":"Gut"},{"key":"2022010415134214000_b17","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1136\/gut.52.6.840","article-title":"Card15 gene overexpression in mononuclear and epithelial cells of the inflamed Crohn's disease colon","volume":"52","author":"Berrebi","year":"2003","journal-title":"Gut"},{"key":"2022010415134214000_b18","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1053\/gast.2003.50153","article-title":"CARD15\/NOD2 functions as an antibacterial factor in human intestinal epithelial cells","volume":"124","author":"Hisamatsu","year":"2003","journal-title":"Gastroenterology"},{"key":"2022010415134214000_b19","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.mvr.2005.11.010","article-title":"Human endothelial cells express NOD2\/CARD15 and increase IL-6 secretion in response to muramyl dipeptide","volume":"71","author":"Davey","year":"2006","journal-title":"Microvasc Res"},{"key":"2022010415134214000_b20","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1053\/gast.2003.50157","article-title":"TNF-alpha and IFN-gamma regulate the expression of the NOD2 (CARD15) gene in human intestinal epithelial cells","volume":"124","author":"Rosenstiel","year":"2003","journal-title":"Gastroenterology"},{"key":"2022010415134214000_b21","doi-asserted-by":"crossref","first-page":"8869","DOI":"10.1074\/jbc.C200651200","article-title":"Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection","volume":"278","author":"Girardin","year":"2003","journal-title":"J Biol Chem"},{"key":"2022010415134214000_b22","doi-asserted-by":"crossref","first-page":"5509","DOI":"10.1074\/jbc.C200673200","article-title":"Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease","volume":"278","author":"Inohara","year":"2003","journal-title":"J Biol Chem"},{"key":"2022010415134214000_b23","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1016\/j.cub.2004.12.032","article-title":"The Crohn's disease protein, NOD2, requires RIP2 in order to induce ubiquitinylation of a novel site on NEMO","volume":"14","author":"Abbott","year":"2004","journal-title":"Curr Biol"},{"key":"2022010415134214000_b24","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1146\/annurev.immunol.18.1.621","article-title":"Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity","volume":"18","author":"Karin","year":"2000","journal-title":"Annu Rev Immunol"},{"key":"2022010415134214000_b25","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1007\/s00109-004-0555-y","article-title":"Nuclear factor-kappaB: its role in health and disease","volume":"82","author":"Kumar","year":"2004","journal-title":"J Mol Med"},{"key":"2022010415134214000_b26","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S1097-2765(02)00599-3","article-title":"The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta","volume":"10","author":"Martinon","year":"2002","journal-title":"Mol Cell"},{"key":"2022010415134214000_b27","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nature02664","article-title":"Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf","volume":"430","author":"Mariathasan","year":"2004","journal-title":"Nature"},{"key":"2022010415134214000_b28","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1016\/j.cub.2004.10.027","article-title":"Identification of bacterial muramyl dipeptide as activator of the NALP3\/cryopyrin inflammasome","volume":"14","author":"Martinon","year":"2004","journal-title":"Curr Biol"},{"key":"2022010415134214000_b29","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.cell.2004.05.004","article-title":"Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases","volume":"117","author":"Martinon","year":"2004","journal-title":"Cell"},{"key":"2022010415134214000_b30","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S1074-7613(04)00046-9","article-title":"NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle\u2013Wells autoinflammatory disorder","volume":"20","author":"Agostini","year":"2004","journal-title":"Immunity"},{"key":"2022010415134214000_b31","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1086\/341357","article-title":"Chronic infantile neurological cutaneous and articular syndrome is caused by mutations in CIAS1, a gene highly expressed in polymorphonuclear cells and chondrocytes","volume":"71","author":"Feldmann","year":"2002","journal-title":"Am J Hum Genet"},{"key":"2022010415134214000_b32","doi-asserted-by":"crossref","first-page":"6329","DOI":"10.4049\/jimmunol.171.12.6329","article-title":"Cutting edge: CIAS1\/cryopyrin\/PYPAF1\/NALP3\/CATERPILLER 1.1 is an inducible inflammatory mediator with NF-kappa B suppressive properties","volume":"171","author":"O'Connor","year":"2003","journal-title":"J Immunol"},{"key":"2022010415134214000_b33","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/nature04515","article-title":"Cryopyrin activates the inflammasome in response to toxins and ATP","volume":"440","author":"Mariathasan","year":"2006","journal-title":"Nature"},{"key":"2022010415134214000_b34","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/nature04517","article-title":"Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin\/Nalp3","volume":"440","author":"Kanneganti","year":"2006","journal-title":"Nature"},{"key":"2022010415134214000_b35","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nature04516","article-title":"Gout-associated uric acid crystals activate the NALP3 inflammasome","volume":"440","author":"Martinon","year":"2006","journal-title":"Nature"},{"key":"2022010415134214000_b36","doi-asserted-by":"crossref","first-page":"21924","DOI":"10.1074\/jbc.M401178200","article-title":"Cryopyrin-induced interleukin 1beta secretion in monocytic cells: enhanced activity of disease-associated mutants and requirement for ASC","volume":"279","author":"Dowds","year":"2004","journal-title":"J Biol Chem"},{"key":"2022010415134214000_b37","first-page":"236","volume-title":"Cryopyrin and pyrin activate caspase-1, but not NF-kappaB, via ASC oligomerization","author":"Yu","year":"2006"},{"key":"2022010415134214000_b38","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.immuni.2006.02.004","article-title":"Critical role for NALP3\/CIAS1\/cryopyrin in innate and adaptive immunity through its regulation of caspase-1","volume":"24","author":"Sutterwala","year":"2006","journal-title":"Immunity"},{"key":"2022010415134214000_b39","doi-asserted-by":"crossref","first-page":"24785","DOI":"10.1074\/jbc.M400985200","article-title":"Caspase-1 activates nuclear factor of the kappa-enhancer in B cells independently of its enzymatic activity","volume":"279","author":"Lamkanfi","year":"2004","journal-title":"J Biol Chem"},{"key":"2022010415134214000_b40","doi-asserted-by":"crossref","first-page":"44069","DOI":"10.1074\/jbc.M107373200","article-title":"CARDINAL, a novel caspase recruitment domain protein, is an inhibitor of multiple NF-kappa B activation pathways","volume":"276","author":"Bouchier-Hayes","year":"2001","journal-title":"J Biol Chem"},{"key":"2022010415134214000_b41","doi-asserted-by":"crossref","first-page":"32220","DOI":"10.1074\/jbc.M100433200","article-title":"TUCAN, an antiapoptotic caspase-associated recruitment domain family protein overexpressed in cancer","volume":"276","author":"Pathan","year":"2001","journal-title":"J Biol Chem"},{"key":"2022010415134214000_b42","doi-asserted-by":"crossref","first-page":"13952","DOI":"10.1074\/jbc.M107811200","article-title":"CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis","volume":"277","author":"Razmara","year":"2002","journal-title":"J Biol Chem"},{"key":"2022010415134214000_b43","doi-asserted-by":"crossref","first-page":"9745","DOI":"10.1073\/pnas.0308558101","article-title":"Phospholipases C and A2 control lysosome-mediated IL-1 beta secretion: implications for inflammatory processes","volume":"101","author":"Andrei","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"2022010415134214000_b44","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1172\/JCI111647","article-title":"Normal human alveolar macrophages obtained by bronchoalveolar lavage have a limited capacity to release interleukin-1","volume":"74","author":"Wewers","year":"1984","journal-title":"J Clin Invest"},{"key":"2022010415134214000_b45","doi-asserted-by":"crossref","first-page":"8485","DOI":"10.1073\/pnas.88.19.8485","article-title":"Interleukin 1 is processed and released during apoptosis","volume":"88","author":"Hogquist","year":"1991","journal-title":"Proc Natl Acad Sci USA"},{"key":"2022010415134214000_b46","doi-asserted-by":"crossref","first-page":"15195","DOI":"10.1016\/S0021-9258(17)36591-2","article-title":"Interleukin-1 beta maturation and release in response to ATP and nigericin. Evidence that potassium depletion mediated by these agents is a necessary and common feature of their activity","volume":"269","author":"Perregaux","year":"1994","journal-title":"J Biol Chem"},{"key":"2022010415134214000_b47","doi-asserted-by":"crossref","first-page":"2821","DOI":"10.4049\/jimmunol.154.6.2821","article-title":"ATP induces the release of IL-1 from LPS-primed cells in vivo","volume":"154","author":"Griffiths","year":"1995","journal-title":"J Immunol"},{"key":"2022010415134214000_b48","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1093\/hmg\/ddh182","article-title":"Regulation of IL-8 and IL-1beta expression in Crohn's disease associated NOD2\/CARD15 mutations","volume":"13","author":"Li","year":"2004","journal-title":"Hum Mol Genet"},{"key":"2022010415134214000_b49","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S0022-3476(85)80394-2","article-title":"Familial granulomatous arthritis, iritis, and rash","volume":"107","author":"Blau","year":"1985","journal-title":"J Pediatr"},{"key":"2022010415134214000_b50","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0022-3476(05)81080-7","article-title":"Autosomal dominant granulomatous arthritis, uveitis, skin rash, and synovial cysts","volume":"117","author":"Pastores","year":"1990","journal-title":"J Pediatr"},{"key":"2022010415134214000_b51","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/35079107","article-title":"Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease","volume":"411","author":"Hugot","year":"2001","journal-title":"Nature"},{"key":"2022010415134214000_b52","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/35079114","article-title":"A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease","volume":"411","author":"Ogura","year":"2001","journal-title":"Nature"},{"key":"2022010415134214000_b53","doi-asserted-by":"crossref","first-page":"14981","DOI":"10.1074\/jbc.M500966200","article-title":"Inhibition of RICK\/nuclear factor-kappaB and p38 signaling attenuates the inflammatory response in a murine model of Crohn disease","volume":"280","author":"Hollenbach","year":"2005","journal-title":"J Biol Chem"},{"key":"2022010415134214000_b54","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/j.1749-6632.1998.tb11119.x","article-title":"Cytokine gene transcription by NF-kappa B family members in patients with inflammatory bowel disease","volume":"859","author":"Neurath","year":"1998","journal-title":"Ann NY Acad Sci"},{"key":"2022010415134214000_b55","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1136\/gut.42.4.477","article-title":"Activation of nuclear factor kappa B inflammatory bowel disease","volume":"42","author":"Schreiber","year":"1998","journal-title":"Gut"},{"key":"2022010415134214000_b56","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1046\/j.1462-5822.2003.00304.x","article-title":"Nods, Nalps and Naip: intracellular regulators of bacterial-induced inflammation","volume":"5","author":"Chamaillard","year":"2003","journal-title":"Cell Microbiol"},{"key":"2022010415134214000_b57","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1053\/gast.2003.50019","article-title":"Crohn's disease-associated NOD2 variants share a signaling defect in response to lipopolysaccharide and peptidoglycan","volume":"124","author":"Bonen","year":"2003","journal-title":"Gastroenterology"},{"key":"2022010415134214000_b58","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1126\/science.1103685","article-title":"Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing","volume":"307","author":"Maeda","year":"2005","journal-title":"Science"},{"key":"2022010415134214000_b59","first-page":"305","article-title":"NOD2 3020insC mutation and the pathogenesis of Crohn's disease: impaired IL-1 and beta; production points to a loss-of-function phenotype","volume":"63","author":"Netea","year":"2005","journal-title":"Neth J Med"},{"key":"2022010415134214000_b60","first-page":"35859","volume-title":"The frameshift mutation in Nod2 results in unresponsiveness not only to Nod2- but also Nod1-activating peptidoglycan agonists","author":"Netea","year":"2005"},{"key":"2022010415134214000_b61","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1136\/gut.2003.032805","article-title":"NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expression","volume":"53","author":"Wehkamp","year":"2004","journal-title":"Gut"},{"key":"2022010415134214000_b62","doi-asserted-by":"crossref","first-page":"18129","DOI":"10.1073\/pnas.0505256102","article-title":"Reduced Paneth cell alpha-defensins in ileal Crohn's disease","volume":"102","author":"Wehkamp","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"2022010415134214000_b63","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1097\/00042737-200606000-00007","article-title":"Heterogeneous expression of human cathelicidin hCAP18\/LL-37 in inflammatory bowel diseases","volume":"18","author":"Schauber","year":"2006","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"2022010415134214000_b64","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1074\/jbc.M511044200","article-title":"NOD2\/CARD15 mediates induction of the antimicrobial peptide human beta-defensin-2","volume":"281","author":"Voss","year":"2006","journal-title":"J Biol Chem"},{"key":"2022010415134214000_b65","first-page":"1097","article-title":"Genetic linkage of familial granulomatous inflammatory arthritis, skin rash, and uveitis to chromosome 16","volume":"59","author":"Tromp","year":"1996","journal-title":"Am J Hum Genet"},{"key":"2022010415134214000_b66","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/ng720","article-title":"CARD15 mutations in Blau syndrome","volume":"29","author":"Miceli-Richard","year":"2001","journal-title":"Nat Genet"},{"key":"2022010415134214000_b67","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1038\/sj.ejhg.5201404","article-title":"A new CARD15 mutation in Blau syndrome","volume":"13","author":"Van Duist","year":"2005","journal-title":"Eur J Hum Genet"},{"key":"2022010415134214000_b68","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S1074-7613(04)00055-X","article-title":"Unraveling the NALP-3\/IL-1beta inflammasome: a big lesson from a small mutation","volume":"20","author":"Dinarello","year":"2004","journal-title":"Immunity"},{"key":"2022010415134214000_b69","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/ng756","article-title":"Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle\u2013Wells syndrome","volume":"29","author":"Hoffman","year":"2001","journal-title":"Nat Genet"},{"key":"2022010415134214000_b70","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1136\/ard.2004.031179","article-title":"The T348M mutated form of cryopyrin is associated with defective lipopolysaccharide-induced interleukin 10 production in CINCA syndrome","volume":"64","author":"Bihl","year":"2005","journal-title":"Ann Rheum Dis"},{"key":"2022010415134214000_b71","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1002\/art.10509","article-title":"Association of mutations in the NALP3\/CIAS1\/PYPAF1 gene with a broad phenotype including recurrent fever, cold sensitivity, sensorineural deafness, and AA amyloidosis","volume":"46","author":"Aganna","year":"2002","journal-title":"Arthritis Rheum"}],"container-title":["Clinical and Experimental Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2249.2006.03261.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/cei\/article-pdf\/147\/2\/227\/42057362\/j.1365-2249.2006.03261.x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cei\/article-pdf\/147\/2\/227\/42057362\/j.1365-2249.2006.03261.x.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,9]],"date-time":"2023-05-09T16:46:57Z","timestamp":1683650817000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cei\/article\/147\/2\/227\/6457250"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11,27]]},"references-count":71,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2006,11,27]]},"published-print":{"date-parts":[[2007,1,5]]}},"URL":"https:\/\/doi.org\/10.1111\/j.1365-2249.2006.03261.x","relation":{},"ISSN":["0009-9104","1365-2249"],"issn-type":[{"value":"0009-9104","type":"print"},{"value":"1365-2249","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2007,2]]},"published":{"date-parts":[[2006,11,27]]}}}