{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:23:27Z","timestamp":1792167807324,"version":"4.4.0"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2006,11,29]],"date-time":"2006-11-29T00:00:00Z","timestamp":1164758400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,1,5]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>The non-classical class I major histocompatibility complex molecules human leucocyte antigen (HLA)-G have been shown to play a role in HIV persistence, but no data are available on the expression of the soluble forms HLA-G5 and sHLA-G1 in HIV-infected patients with and without opportunistic infections. The soluble HLA-G isoform was measured with an enzyme-linked immunosorbent assay (ELISA) method in plasma from 94 subjects: 31 HIV-1-seropositive, 17 with visceral leishmaniasis (VL), seven with both VL and HIV-1 infection and 39 healthy HIV-seronegative subjects. Between groups, the frequency of sHLA-G positivity was statistically different: 81% of HIV-infected patients were positive, as were 57% of HIV\u2013Leishmania infantum co-infected patients, 35% of HIV-seronegative patients with VL and 3% of healthy controls. Levels of the soluble forms of the immunomodulatory molecules HLA-G are elevated during HIV infection. In HIV\u2013Leishmania co-infected patients, sHLA-G secretion could contribute to the tolerogenic environment and to Leishmania immune evasion.<\/jats:p>","DOI":"10.1111\/j.1365-2249.2006.03268.x","type":"journal-article","created":{"date-parts":[[2006,11,29]],"date-time":"2006-11-29T15:58:10Z","timestamp":1164815890000},"page":"236-240","source":"Crossref","is-referenced-by-count":50,"title":["Elevated levels of soluble non-classical major histocompatibility class I molecule human leucocyte antigen (HLA)-G in the blood of HIV-infected patients with or without visceral leishmaniasis"],"prefix":"10.1093","volume":"147","author":[{"given":"L","family":"Donaghy","sequence":"first","affiliation":[{"name":"Inserm U522, Rennes, CHU de Rennes, France"},{"name":"Laboratoire de Parasitologie-Mycologie, Facult\u00e9 de M\u00e9decine de Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Gros","sequence":"additional","affiliation":[{"name":"UPRES EA 3889 Immunologie-h\u00e9matologie, Facult\u00e9 de M\u00e9decine de Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Amiot","sequence":"additional","affiliation":[{"name":"UPRES EA 3889 Immunologie-h\u00e9matologie, Facult\u00e9 de M\u00e9decine de Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Mary","sequence":"additional","affiliation":[{"name":"Laboratoire de Parasitologie-Mycologie, CHU de Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Maillard","sequence":"additional","affiliation":[{"name":"Laboratoire de Bact\u00e9riologie-Virologie, CHU de Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Guiguen","sequence":"additional","affiliation":[{"name":"Inserm U522, Rennes, CHU de Rennes, France"},{"name":"Laboratoire de Parasitologie-Mycologie, Facult\u00e9 de M\u00e9decine de Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J-P","family":"Gangneux","sequence":"additional","affiliation":[{"name":"Inserm U522, Rennes, CHU de Rennes, France"},{"name":"Laboratoire de Parasitologie-Mycologie, Facult\u00e9 de M\u00e9decine de Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2006,11,29]]},"reference":[{"key":"2022010415134307700_b1","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1006\/smim.2000.0213","article-title":"NK cell recognition of non-classical HLA class I molecules","volume":"12","author":"Lopez-Botet","year":"2000","journal-title":"Semin Immunol"},{"key":"2022010415134307700_b2","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/S0198-8859(03)00091-0","article-title":"Soluble HLA-G inhibits human dendritic cell-triggered allogeneic T-cell proliferation without altering dendritic differentiation and maturation 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