{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T14:02:03Z","timestamp":1783519323902,"version":"3.55.0"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2006,12,20]],"date-time":"2006-12-20T00:00:00Z","timestamp":1166572800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,1,5]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>The Mycobacterium tuberculosis phoP mutant strain SO2 has been shown previously to be more attenuated than Mycobacterium bovis bacillus Calmette\u2013Gu\u00e9rin (BCG) and confers protective immunity against tuberculosis in mice and guinea pig models. In this study we have investigated the survival and immunological responses of Balb\/c mice infected with the M. tuberculosis SO2 strain. All Balb\/C mice survived intratracheal infection with M. tuberculosis SO2 strain under conditions where all the mice infected with the parental M. tuberculosis MT103 had died after 9 weeks. Infection of Balb\/c mice with M. tuberculosis SO2 was associated with comparatively lower levels of interferon (IFN)-\u03b3, interleukin (IL)-4 and tumour necrosis factor (TNF)-\u03b1 and higher levels of inducible nitric oxide synthase (iNOS) during the late stage of infection, when compared with M. tuberculosis MT103 infection. The delayed-type hypersensitivity (DTH) response against M. tuberculosis culture filtrates was similar in mice infected with either the M. tuberculosis phoP SO2 strain or M. tuberculosis MT103. The protective efficacy of M. tuberculosis SO2 was compared with M. bovis BCG when delivered subcutaneously to groups of Balb\/C mice. Following intratracheal challenge with M. tuberculosis H37Rv, protection was generated by 60\u2003days post-challenge in mice vaccinated with either vaccine. At day 120 post-challenge the levels of protection were still significantly greater when compared with the non-vaccinated control group. The levels of protection conferred by vaccination with M. tuberculosis SO2 or with M. bovis BCG were similar, as measured by granuloma coalescence and pneumonia in addition to growth reduction of M. tuberculosis H37Rv.<\/jats:p>","DOI":"10.1111\/j.1365-2249.2006.03284.x","type":"journal-article","created":{"date-parts":[[2010,8,12]],"date-time":"2010-08-12T14:31:42Z","timestamp":1281623502000},"page":"330-338","source":"Crossref","is-referenced-by-count":35,"title":["Immunological responses and protective immunity against tuberculosis conferred by vaccination of Balb\/C mice with the attenuated <i>Mycobacterium tuberculosis<\/i> (<i>phoP<\/i>) SO2 strain"],"prefix":"10.1093","volume":"147","author":[{"given":"D","family":"Aguilar","sequence":"first","affiliation":[{"name":"Experimental Pathology Section, Department of Pathology, National Institute of Medical Sciences and Nutrition \u2018Salvador Zubir\u00e0n\u2019, Mexico City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Infante","sequence":"additional","affiliation":[{"name":"Experimental Pathology Section, Department of Pathology, National Institute of Medical Sciences and Nutrition \u2018Salvador Zubir\u00e0n\u2019, Mexico City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Martin","sequence":"additional","affiliation":[{"name":"Grupo de Gen\u00e9tica de Micobacterias Departamento de Microbiolog\u00eda Medicina Preventiva y Salud P\u00fablica, Universidad de Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Gormley","sequence":"additional","affiliation":[{"name":"UCD School of Agriculture, Food Science and Veterinary Medicine, University College Dublin, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Gicquel","sequence":"additional","affiliation":[{"name":"Unit\u00e9 G\u00e9netique Mycobact\u00e9rienne, Institut Pasteur, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Hernandez Pando","sequence":"additional","affiliation":[{"name":"Experimental Pathology Section, Department of Pathology, National Institute of Medical Sciences and Nutrition \u2018Salvador Zubir\u00e0n\u2019, Mexico City"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2006,12,20]]},"reference":[{"key":"2022010415134953700_b1","volume-title":"Global tuberculosis control\u2003\u2212\u2003surveillance, planning, financing","author":"World Health Organization (WHO)","year":"2005"},{"key":"2022010415134953700_b2","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.cell.2006.02.013","article-title":"The development and impact of tuberculosis 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