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Many approaches are being utilised to enhance understanding of the requirements of a successful vaccine. Numerous vaccines are being designed and assessed in a series of animal models, with a few progressing to clinical trials. Here, the steps involved in the development and evaluation of TB vaccines will be discussed, including description of the most frequently used animal models and the processes involved in advancing vaccines to phase III trials.<\/jats:p>","DOI":"10.1111\/j.1365-2249.2006.03306.x","type":"journal-article","created":{"date-parts":[[2008,10,13]],"date-time":"2008-10-13T18:50:13Z","timestamp":1223923813000},"page":"401-411","source":"Crossref","is-referenced-by-count":23,"title":["Translational Mini-Review Series on Vaccines:&amp;#x2028;Development and evaluation of improved vaccines against tuberculosis"],"prefix":"10.1093","volume":"147","author":[{"given":"C","family":"Sander","sequence":"first","affiliation":[{"name":"University of Oxford, CCVTM, Churchill Hospital, Oxford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"McShane","sequence":"additional","affiliation":[{"name":"University of Oxford, CCVTM, Churchill Hospital, Oxford, 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