{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:47:15Z","timestamp":1761155235053},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2007,1,15]],"date-time":"2007-01-15T00:00:00Z","timestamp":1168819200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,1,15]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>The recommended control option against onchocerciasis is repeated ivermectin treatment, which will need to be implemented for decades, and it remains unknown how repeated ivermectin therapy might affect immunity against Onchocerca volvulus in the long term. O. volvulus-specific antibody reactivity and cellular cytokine production were investigated in onchocerciasis patients receiving ivermectin (150\u2003\u00b5g\/kg) annually for 16\u2003years. In treated patients, the T helper type 2 (Th2) cytokine interleukin (IL)-5 and T regulatory IL-10 in response to O. volvulus antigen (OvAg) and bacteria-derived Streptolysin O (SL-O) diminished to levels found in infection-free endemic controls; also, cellular release of Th1-type interferon (IFN)-\u03b3 at 16\u2003years post initial ivermectin treatment (p.i.t.) approached control levels. In ivermectin-treated onchocerciasis patients, IL-5 production in responses to the mitogen phytohaemagglutinin (PHA) decreased, but IL-10 in response PHA increased, and neither attained the cytokine production levels of endemic controls. At 16\u2003years p.i.t., O. volvulus-specific IgG1 and IgG4 subclass reactivity still persisted at higher levels in onchocerciasis patients than in O. volvulus exposed but microfilariae-free endemic controls. In addition, cytokine responses remained depressed in onchocerciasis patients infected concurrently with Mansonella perstans and Necator americanus or Entamoeba histolytica\/dispar. Thus, long-term ivermectin therapy of onchocerciasis may not suffice to re-establish fully a balanced Th1 and Th2 immune responsiveness in O. volvulus microfilariae-negative individuals. Such deficient reconstitution of immune competence may be due to an as yet continuing and uncontrolled reinfection with O. volvulus, but parasite co-infections can also bias and may prevent the development of such immunity.<\/jats:p>","DOI":"10.1111\/j.1365-2249.2006.03312.x","type":"journal-article","created":{"date-parts":[[2008,10,13]],"date-time":"2008-10-13T18:50:13Z","timestamp":1223923813000},"page":"504-512","source":"Crossref","is-referenced-by-count":14,"title":["<i>Onchocerca volvulus<\/i>-specific antibody and cytokine responses in onchocerciasis patients after 16 years of repeated ivermectin therapy"],"prefix":"10.1093","volume":"147","author":[{"given":"C S","family":"Mai","sequence":"first","affiliation":[{"name":"Institute for Tropical Medicine, University of T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D M","family":"Hamm","sequence":"additional","affiliation":[{"name":"Institute for Tropical Medicine, University of T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Banla","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lom\u00e9, Facult\u00e9 Mixte de M\u00e9decine et Pharmacie, Lom\u00e9, Togo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Agossou","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Regional, Service P\u00e9diatrie, Sokod\u00e9, Togo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Schulz-Key","sequence":"additional","affiliation":[{"name":"Institute for Tropical Medicine, University of T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Heuschkel","sequence":"additional","affiliation":[{"name":"Institute for Tropical Medicine, University of T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P 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