{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T12:46:17Z","timestamp":1788266777501,"version":"build-2803163510"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2007,3,15]],"date-time":"2007-03-15T00:00:00Z","timestamp":1173916800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,3,15]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>We have investigated the possible role of the metabolism of tryptophan and activity of the enzyme indoleamine 2,3-dioxygenase (IDO) in the immune regulation of coeliac disease (CD). Serum concentrations of tryptophan and its metabolites kinurenines were determined by high performance liquid chromatography in 24 patients with CD, seven patients with Crohn's disease and five healthy patients. We detected an increase of kynurenine (4\u00b72\u2003\u00b5mol\/l\u2003\u00b1\u20030\u00b727 versus 2\u00b76\u2003\u00b5mol\/l\u2003\u00b1\u20030\u00b754, P\u2003&amp;lt;\u20030002) and of the kynurenine\/tryptophan ratio in supernatants of coeliac patients (11\u00b75\u2003\u00b5mol\/l\u2003\u00b1\u20031\u00b701 versus 6\u00b75\u2003\u00b5mol\/l\u2003\u00b1\u20031\u00b757, P\u2003&amp;lt;\u20030005) in comparison with healthy patients, respectively, and we found no differences with Crohn's disease patients. Immunohistochemistry analysis of intestinal biopsies from CD patients showed an increased expression of IDO, interferon-\u03b3, interleukin-10 and transforming growth factor-\u03b2. Our data suggest that a mechanism(s) dependent on tryptophan catabolism might regulate the immune responses in CD.<\/jats:p>","DOI":"10.1111\/j.1365-2249.2007.03365.x","type":"journal-article","created":{"date-parts":[[2010,8,5]],"date-time":"2010-08-05T19:14:25Z","timestamp":1281035665000},"page":"419-424","source":"Crossref","is-referenced-by-count":54,"title":["Tryptophan metabolism and indoleamine 2,3-dioxygenase expression in coeliac disease"],"prefix":"10.1093","volume":"148","author":[{"given":"M I","family":"Torres","sequence":"first","affiliation":[{"name":"Department of Experimental Biology, University of Ja\u00e9n, Ja\u00e9n"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M A","family":"L\u00f3pez-Casado","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Pediatrics, Hospital Virgen de las Nieves, Granada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Lorite","sequence":"additional","affiliation":[{"name":"Department of Experimental Biology, University of Ja\u00e9n, Ja\u00e9n"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"R\u00edos","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, University of Granada, Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2007,3,15]]},"reference":[{"key":"2022010414515295800_b1","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/nri885","article-title":"Celiac disease: dissecting a complex inflammatory disorder","volume":"2","author":"Sollid","year":"2002","journal-title":"Nat Rev Immunol"},{"key":"2022010414515295800_b2","doi-asserted-by":"crossref","first-page":"289","DOI":"10.7326\/0003-4819-142-4-200502150-00011","article-title":"Narrative review: celiac disease: 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