{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T14:52:57Z","timestamp":1773672777263,"version":"3.50.1"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2007,4,2]],"date-time":"2007-04-02T00:00:00Z","timestamp":1175472000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,4,25]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>We present a case with subacute limbic encephalitis (LE) and thymoma. Neither classical onconeural antibodies nor antibodies to voltage gated potassium channels (VGKC) were detected, but the serum was positive for anti-glutamic acid decarboxylase (GAD). The patient serum also stained synaptic boutons of pyramidal cells and nuclei of granule cells of rat hippocampus. The objective of the study was to identify new antibodies associated with LE. Screening a cDNA expression library identified collapsin response mediator protein 3 (CRMP3), a protein involved in neurite outgrowth. The serum also reacted with both CRMP3 and CRMP4 by Western blot. Similar binding pattern of hippocampal granule cells was obtained with the patient serum and rabbit anti-serum against CRMP1\u20134. The CRMP1\u20134 antibodies stained neuronal nuclei of a biopsy from the patient's temporal lobe, but CRMP1\u20134 expression in thymoma could only be detected by immunoblotting. Absorption studies with recombinant GAD failed to abolish the staining of the hippocampal granule cells. Our findings illustrate that CRMP3\u20134 antibodies can be associated with LE and thymoma. This has previously been associated with CRMP5.<\/jats:p>","DOI":"10.1111\/j.1365-2249.2007.03379.x","type":"journal-article","created":{"date-parts":[[2010,8,12]],"date-time":"2010-08-12T14:29:54Z","timestamp":1281623394000},"page":"16-22","source":"Crossref","is-referenced-by-count":31,"title":["Antibodies to CRMP3\u20134 associated with limbic encephalitis and thymoma"],"prefix":"10.1093","volume":"149","author":[{"given":"A","family":"Knudsen","sequence":"first","affiliation":[{"name":"Department of Neurology, Haukeland University Hospital, Bergen, Norway"},{"name":"Department of Clinical Medicine, University of Bergen, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Bredholt","sequence":"additional","affiliation":[{"name":"Department of Pathology, Haukeland University Hospital, Bergen, Norway"},{"name":"The Gade Institute, University of Bergen, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Storstein","sequence":"additional","affiliation":[{"name":"Department of Neurology, Haukeland University Hospital, Bergen, Norway"},{"name":"Department of Clinical Medicine, University of Bergen, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Oltedal","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, University of Bergen, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Davanger","sequence":"additional","affiliation":[{"name":"Institute of Anatomy and Cell Biology, University of Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Krossnes","sequence":"additional","affiliation":[{"name":"Department of Pathology, Haukeland University Hospital, Bergen, Norway"},{"name":"The Gade Institute, University of Bergen, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Honnorat","sequence":"additional","affiliation":[{"name":"INSERM U433, Universit\u00e9 Claude Bernard Lyon 1, H\u00f4pital Neurologique, Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C A","family":"Vedeler","sequence":"additional","affiliation":[{"name":"Department of Neurology, Haukeland University Hospital, Bergen, Norway"},{"name":"Department of Clinical Medicine, University of Bergen, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2007,4,2]]},"reference":[{"key":"2022010406292645100_b1","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1136\/jnnp.2003.034447","article-title":"Recommended diagnostic criteria for paraneoplastic neurological syndromes","volume":"75","author":"Graus","year":"2004","journal-title":"J Neurol Neurosurg 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