{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T08:40:57Z","timestamp":1761986457438},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2008,1,24]],"date-time":"2008-01-24T00:00:00Z","timestamp":1201132800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,1,24]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>To date, there is very little information regarding the pathomechanism of IgA anaphylactoid reactions and the management of affected patients. Five adult patients with common variable immunodeficiency (CVID) and a history of anaphylactic reactions due to the administration of immunoglobulin preparations were studied. The activity of anti-IgA was determined by the gel agglutination technique using IgA-coated beads. Antibodies to IgA were detected in the serum of all five patients. Initially, IgA \u2018depleted\u2019 intravenous (i.v.) IgG preparations were infused carefully into the patients until the activity of anti-IgA was decreased significantly or became undetectable. Subsequently, unselected i.v. IgG preparations were infused, and the activity of anti-IgA was abolished in all cases. Intravenous IgG long-term administration results in tolerance induction in patients with IgA anaphylactoid reactions. This tolerance appears to be related to antibody blockage in the circulation and an inhibition of antibody production. Most importantly, IgA appears to play an important role in the treatment of CVID. Patients with IgA anaphylactoid reactions can be treated safely with IgA containing i.v. IgG preparations following tolerance induction.<\/jats:p>","DOI":"10.1111\/j.1365-2249.2007.03483.x","type":"journal-article","created":{"date-parts":[[2010,7,27]],"date-time":"2010-07-27T09:49:49Z","timestamp":1280224189000},"page":"455-458","source":"Crossref","is-referenced-by-count":17,"title":["Immune tolerance induction in patients with IgA anaphylactoid reactions following long-term intravenous IgG treatment"],"prefix":"10.1093","volume":"151","author":[{"given":"N","family":"Ahrens","sequence":"first","affiliation":[{"name":"Institute for Transfusion Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"H\u00f6flich","sequence":"additional","affiliation":[{"name":"Institute for Medical Immunology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Bombard","sequence":"additional","affiliation":[{"name":"DiaMed, Cressier sur Morat, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Lochs","sequence":"additional","affiliation":[{"name":"Department for Gastrology, Hepatology, and Endocrinology, Charit\u00e9 \u2013 University Medicine Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Kiesewetter","sequence":"additional","affiliation":[{"name":"Institute for Transfusion Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Salama","sequence":"additional","affiliation":[{"name":"Institute for Transfusion Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2008,1,24]]},"reference":[{"key":"2022010406282219300_b1","doi-asserted-by":"crossref","first-page":"226","DOI":"10.21307\/immunohematology-2019-454","article-title":"IgA anaphylactic transfusion reactions. Part I. Laboratory diagnosis, incidence, and supply of IgA-deficient products [Review]","volume":"20","author":"Vassallo","year":"2004","journal-title":"Immunohematology"},{"key":"2022010406282219300_b2","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1046\/j.1537-2995.1990.30490273440.x","article-title":"Preparation of IgA-deficient platelets","volume":"30","author":"Sloand","year":"1990","journal-title":"Transfusion"},{"key":"2022010406282219300_b3","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1423-0410.1992.tb01229.x","article-title":"Transfusion management of patients with IgA deficiency and anti-IgA during liver transplantation","volume":"63","author":"Davenport","year":"1992","journal-title":"Vox Sang"},{"key":"2022010406282219300_b4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0887-7963(05)80026-4","article-title":"IgA anaphylactic transfusion reactions","volume":"9","author":"Sandler","year":"1995","journal-title":"Transfus Med Rev"},{"key":"2022010406282219300_b5","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1159\/000462004","article-title":"Transfusion support for a patient with severe common variable immunodeficiency with anti-IgA undergoing orthotopic liver transplantation","volume":"72","author":"Win","year":"1997","journal-title":"Vox Sang"},{"key":"2022010406282219300_b6","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1007\/BF00919386","article-title":"Long-term use of IgA-depleted intravenous immunoglobulin in immunodeficient subjects with anti-IgA antibodies","volume":"13","author":"Cunningham-Rundles","year":"1993","journal-title":"J Clin Immunol"},{"key":"2022010406282219300_b7","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/0140-6736(91)90147-H","article-title":"Home treatment of hypogammaglobulinaemia with subcutaneous gammaglobulin by rapid infusion","volume":"338","author":"Gardulf","year":"1991","journal-title":"Lancet"},{"key":"2022010406282219300_b8","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1111\/j.1537-2995.2004.03316.x","article-title":"A new strategy for the prevention of IgA anaphylactic transfusion reactions","volume":"44","author":"Salama","year":"2004","journal-title":"Transfusion"},{"key":"2022010406282219300_b9","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1046\/j.1423-0410.2001.00047.x","article-title":"Rapid detection of antibodies to immunoglobulin A molecules by using the particle gel immunoassay","volume":"81","author":"Salama","year":"2001","journal-title":"Vox Sang"},{"key":"2022010406282219300_b10","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0090-1229(88)90072-4","article-title":"Anti-IgA antibodies in selective IgA deficiency and in primary immunodeficient patients treated with gamma-globulin","volume":"47","author":"Ferreira","year":"1988","journal-title":"Clin Immunol Immunopathol"},{"key":"2022010406282219300_b11","doi-asserted-by":"crossref","first-page":"155","DOI":"10.21307\/immunohematology-2019-686","article-title":"A comprehensive IgA service provided by a blood transfusion center","volume":"14","author":"Munks","year":"1998","journal-title":"Immunohematology"},{"key":"2022010406282219300_b12","doi-asserted-by":"crossref","first-page":"234","DOI":"10.21307\/immunohematology-2019-455","article-title":"IgA anaphylactic transfusion reactions. Part II. Clinical diagnosis and bedside management [Review]","volume":"20","author":"Sandler","year":"2004","journal-title":"Immunohematology"},{"key":"2022010406282219300_b13","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1046\/j.1445-5994.2001.00053.x","article-title":"Safe and effective use of chromatographically purified intravenous immunoglobulin despite profound anti-IgA sensitization","volume":"31","author":"Limaye","year":"2001","journal-title":"Intern Med J"},{"key":"2022010406282219300_b14","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/0090-1229(82)90022-8","article-title":"Use of intravenous gamma-globulin in antibody immunodeficiency: results of a multicenter controlled trial","volume":"22","author":"Ammann","year":"1982","journal-title":"Clin Immunol Immunopathol"},{"key":"2022010406282219300_b15","doi-asserted-by":"crossref","first-page":"435","DOI":"10.7326\/0003-4819-101-4-435","article-title":"Efficacy of intravenous immunoglobulin in primary humoral immunodeficiency disease","volume":"101","author":"Cunningham-Rundles","year":"1984","journal-title":"Ann Intern Med"},{"key":"2022010406282219300_b16","doi-asserted-by":"crossref","first-page":"367","DOI":"10.7326\/0003-4819-107-2-367","article-title":"Intravenous immunoglobulins as therapeutic agents","volume":"107","author":"Stiehm","year":"1987","journal-title":"Ann Intern Med"},{"key":"2022010406282219300_b17","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1046\/j.1365-2249.1998.00571.x","article-title":"Induction of unresponsiveness against IgA in IgA-deficient patients on subcutaneous immunoglobulin infusion therapy","volume":"112","author":"Sundin","year":"1998","journal-title":"Clin Exp Immunol"},{"key":"2022010406282219300_b18","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1046\/j.1365-3083.1996.d01-72.x","article-title":"Inhibition of immunoglobulin production in vitro by IgG and F(ab\u2032) 2 fragments, but not by the Fc portion","volume":"43","author":"Klaesson","year":"1996","journal-title":"Scand J Immunol"},{"key":"2022010406282219300_b19","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0091-6749(98)70130-7","article-title":"Intravenous immunoglobulin inhibits IgE production in human B lymphocytes","volume":"102","author":"Sigman","year":"1998","journal-title":"J Allergy Clin Immunol"},{"key":"2022010406282219300_b20","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1067\/mai.2001.116291","article-title":"Inhibition of IgE production in vitro by intact and fragmented intravenous immunoglobulin","volume":"108","author":"Zhuang","year":"2001","journal-title":"J Allergy Clin Immunol"}],"container-title":["Clinical and Experimental Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2249.2007.03483.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2249.2007.03483.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/cei\/article-pdf\/151\/3\/455\/42045619\/j.1365-2249.2007.03483.x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cei\/article-pdf\/151\/3\/455\/42045619\/j.1365-2249.2007.03483.x.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T06:33:50Z","timestamp":1641278030000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cei\/article\/151\/3\/455\/6494720"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1,24]]},"references-count":20,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2008,1,24]]},"published-print":{"date-parts":[[2008,1,24]]}},"URL":"https:\/\/doi.org\/10.1111\/j.1365-2249.2007.03483.x","relation":{},"ISSN":["0009-9104","1365-2249"],"issn-type":[{"value":"0009-9104","type":"print"},{"value":"1365-2249","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2008,3]]},"published":{"date-parts":[[2008,1,24]]}}}