{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T23:06:28Z","timestamp":1762297588070},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2007,8,23]],"date-time":"2007-08-23T00:00:00Z","timestamp":1187827200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,8,23]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>The aim of this study was to clarify the nature of the clonal lymphocyte infiltration in Sj\u00f6gren's syndrome (SS) patients associated with lymphoproliferative disorders. We examined B cell clonality in lymphoproliferative tissues from six primary SS patients associated with lymphoproliferative disorders or lymphoma by cloning and sequencing of the gene rearrangement of the immunoglobulin heavy chain complementarity determining region 3 (IgVH\u2013CDR3). Three patients with sequential observation showed progressional clonal expansion with the presence of the same subclone in different tissues during the course of disease. Among them, one patient developed mucosa-associated lymphoid tissue (MALT) lymphoma in glandular parotid. The other three SS patients concomitant with malignant B cells lymphomas showed different clonal expansion of B cells between nodal sites and salivary glands. The cloanality analysis indicated that monoclonal B cell population could spread from one glandular site to another site during the course of SS, suggesting that the malignant clone may arise from the general abnormal microenvironment, not restricted to the glandular tissue, in some SS patients.<\/jats:p>","DOI":"10.1111\/j.1365-2249.2007.03486.x","type":"journal-article","created":{"date-parts":[[2010,8,12]],"date-time":"2010-08-12T14:10:51Z","timestamp":1281622251000},"page":"279-284","source":"Crossref","is-referenced-by-count":24,"title":["Clonality analysis of lymphoproliferative disorders in patients with Sj\u00f6gren's syndrome"],"prefix":"10.1093","volume":"150","author":[{"given":"L","family":"Dong","sequence":"first","affiliation":[{"name":"Department of Hematology and Immunology, Kanazawa Medical University"},{"name":"Department of Hematology and Immunology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Masaki","sequence":"additional","affiliation":[{"name":"Department of Hematology and Immunology, Kanazawa Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Takegami","sequence":"additional","affiliation":[{"name":"Department of Molecular Oncology and Virology, Kanazawa Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z-X","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Hematology and Immunology, Kanazawa Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C-R","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Hematology and Immunology, Kanazawa Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Fukushima","sequence":"additional","affiliation":[{"name":"Department of Hematology and Immunology, Kanazawa Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Sawaki","sequence":"additional","affiliation":[{"name":"Department of Hematology and Immunology, Kanazawa Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Kawanami","sequence":"additional","affiliation":[{"name":"Department of Hematology and Immunology, Kanazawa Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Saeki","sequence":"additional","affiliation":[{"name":"Nagaoka Red Cross Hospital, Nagaoka, Niigata, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Kitagawa","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Kanazawa Medical University, Ishikawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Sugai","sequence":"additional","affiliation":[{"name":"Department of Hematology and Immunology, Kanazawa Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Okazaki","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Tottori University, Yonago, Tottori, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Hirose","sequence":"additional","affiliation":[{"name":"Department of Hematology and Immunology, Kanazawa Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Umehara","sequence":"additional","affiliation":[{"name":"Department of Hematology and Immunology, Kanazawa Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2007,8,23]]},"reference":[{"key":"2022010406284313500_b1","doi-asserted-by":"crossref","first-page":"212","DOI":"10.7326\/0003-4819-92-2-212","article-title":"Sjogren's syndrome (Sicca syndrome): Curr Issues","volume":"92","author":"Moutsopoulos","year":"1980","journal-title":"Ann Intern Med"},{"key":"2022010406284313500_b2","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1097\/00005792-199211000-00005","article-title":"Sjogren's syndrome. 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