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Leishmania infantum LiP2a and LiP2b acidic ribosomal protein (P proteins) have been described as prominent antigens during human and canine visceral leishmaniasis. In this study we demonstrate that BALB\/c mice infected with Leishmania major develop a Th2-like humoral response against Leishmania LiP2a and LiP2b proteins and that the same response is induced in BALB\/c mice when the parasite P proteins are immunized as recombinant molecules without adjuvant. The genetic immunization of BALB\/c mice with eukaryotic expression plasmids coding for these proteins was unable to redirect the Th2-like response induced by these antigens, and only the co-administration of the recombinant P proteins with CpG oligodeoxynucleotides (CpG ODN) promoted a mixed Th1\/Th2 immune response. According to the preponderance of a Th2 or mixed Th1\/Th2 responses elicited by the different regimens of immunization tested, no evidence of protection was observed in mice after challenge with L.\u2003major. Although alterations of the clinical outcome were not detected in mice presensitized with the P proteins, the enhanced IgG1 and interleukin (IL)-4 response against total Leishmania antigens in these mice may indicate an exacerbation of the disease.<\/jats:p>","DOI":"10.1111\/j.1365-2249.2007.03501.x","type":"journal-article","created":{"date-parts":[[2010,8,12]],"date-time":"2010-08-12T13:59:21Z","timestamp":1281621561000},"page":"375-385","source":"Crossref","is-referenced-by-count":17,"title":["The immunodominant T helper 2 (Th2) response elicited in BALB\/c mice by the<i>Leishmania<\/i>LiP2a and LiP2b acidic ribosomal proteins cannot be reverted by strong Th1 inducers"],"prefix":"10.1093","volume":"150","author":[{"given":"S","family":"Iborra","sequence":"first","affiliation":[{"name":"Centro de Biolog\u00eda Molecular Severo Ochoa, Departamento de Biolog\u00eda Molecular, Facultad de Ciencias, Universidad Aut\u00f3noma de Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D R","family":"Ab\u00e1nades","sequence":"additional","affiliation":[{"name":"Centro de Biolog\u00eda Molecular Severo Ochoa, Departamento de Biolog\u00eda Molecular, Facultad de Ciencias, Universidad Aut\u00f3noma de Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Parody","sequence":"additional","affiliation":[{"name":"Centro de Biolog\u00eda Molecular Severo Ochoa, Departamento de Biolog\u00eda Molecular, Facultad de Ciencias, Universidad Aut\u00f3noma de Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Carri\u00f3n","sequence":"additional","affiliation":[{"name":"Centro de Biolog\u00eda Molecular Severo Ochoa, Departamento de Biolog\u00eda Molecular, Facultad de Ciencias, Universidad Aut\u00f3noma de Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R M","family":"Risue\u00f1o","sequence":"additional","affiliation":[{"name":"Centro de Biolog\u00eda Molecular Severo Ochoa, Departamento de Biolog\u00eda Molecular, Facultad de Ciencias, Universidad Aut\u00f3noma de Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M A","family":"Pineda","sequence":"additional","affiliation":[{"name":"Centro de Biolog\u00eda Molecular Severo Ochoa, Departamento de Biolog\u00eda Molecular, Facultad de Ciencias, Universidad Aut\u00f3noma de Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Bonay","sequence":"additional","affiliation":[{"name":"Centro de Biolog\u00eda Molecular Severo Ochoa, Departamento de Biolog\u00eda Molecular, Facultad de Ciencias, Universidad Aut\u00f3noma de Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Alonso","sequence":"additional","affiliation":[{"name":"Centro de Biolog\u00eda Molecular Severo Ochoa, Departamento de Biolog\u00eda Molecular, Facultad de Ciencias, Universidad Aut\u00f3noma de Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Soto","sequence":"additional","affiliation":[{"name":"Centro de Biolog\u00eda Molecular Severo Ochoa, Departamento de Biolog\u00eda Molecular, Facultad de Ciencias, Universidad Aut\u00f3noma de Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2007,9,27]]},"reference":[{"key":"2022010406284897900_b1","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/S0140-6736(98)10178-2","article-title":"Leishmaniasis","volume":"354","author":"Herwaldt","year":"1999","journal-title":"Lancet"},{"key":"2022010406284897900_b2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1475-9292-1-1","article-title":"Molecular determinants and regulation of Leishmania virulence","volume":"1","author":"Chang","year":"2002","journal-title":"Kinetoplastid Biol Dis"},{"key":"2022010406284897900_b3","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0001-706X(02)00238-3","article-title":"Leishmania model for microbial virulence: the relevance of parasite multiplication and pathoantigenicity","volume":"85","author":"Chang","year":"2003","journal-title":"Acta Trop"},{"key":"2022010406284897900_b4","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1046\/j.1365-3024.1996.d01-39.x","article-title":"Immunopathology of the uveitis in canine leishmaniasis","volume":"18","author":"Garcia-Alonso","year":"1996","journal-title":"Parasite Immunol"},{"key":"2022010406284897900_b5","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1046\/j.1365-3024.1996.d01-28.x","article-title":"Presence of antibodies in the aqueous humour and cerebrospinal fluid during Leishmania infections in dogs. 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