{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T15:58:52Z","timestamp":1793289532223,"version":"4.5.0"},"reference-count":108,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2007,12,7]],"date-time":"2007-12-07T00:00:00Z","timestamp":1196985600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,12,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>OTHER ARTICLES PUBLISHED IN THIS TRANSLATIONAL MINI-REVIEW SERIES ON COMPLEMENT FACTOR H<\/jats:p><jats:p>Structural and functional correlations for factor H. Clin Exp Immunol 2008; 151: doi:10.1111\/j.1365-2249.2007.03553.x<\/jats:p><jats:p>Therapies of renal diseases associated with complement factor H abnormalities: atypical haemolytic uraemic syndrome and membranoproliferative glomerulonephritis. Clin Exp Immunol 2008; 151: doi:10.1111\/j.1365-2249.2007.03558.x<\/jats:p><jats:p>Renal diseases associated with complement factor H: novel insights from humans and animals. Clin Exp Immunol 2008; 151: doi:10.1111\/j.1365-2249.2007.03574.x<\/jats:p><jats:p>Factor H is an abundant plasma glycoprotein that plays a critical role in the regulation of the complement system in plasma and in the protection of host cells and tissues from damage by complement activation. Several recent studies have described the association of genetic variations of the complement factor H gene (CFH) with atypical haemolytic uraemic syndrome (aHUS), age-related macular degeneration (AMD) and membranoproliferative glomerulonephritis (MPGN). This review summarizes our current knowledge of CFH genetics and examines the CFH genotype\u2013phenotype correlations that are helping to understand the molecular basis underlying these renal and ocular pathologies.<\/jats:p>","DOI":"10.1111\/j.1365-2249.2007.03552.x","type":"journal-article","created":{"date-parts":[[2010,7,29]],"date-time":"2010-07-29T12:21:32Z","timestamp":1280406092000},"page":"1-13","source":"Crossref","is-referenced-by-count":240,"title":["Translational Mini-Review Series on Complement Factor H: Genetics and disease associations of human complement factor H"],"prefix":"10.1093","volume":"151","author":[{"given":"S Rodr\u00edguez","family":"De C\u00f3rdoba","sequence":"first","affiliation":[{"name":"Centro de Investigaciones Biol\u00f3gicas and Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E Goicoechea","family":"De Jorge","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Biol\u00f3gicas and Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2007,12,7]]},"reference":[{"key":"2022010406280744900_b1","volume-title":"Complement","author":"Law","year":"1995","edition":"2nd"},{"key":"2022010406280744900_b2","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1084\/jem.146.1.257","article-title":"Human complement C3b inactivator: isolation, characterization, and demonstration of an absolute requirement for the serum protein beta1H for cleavage of C3b and C4b in solution","volume":"146","author":"Pangburn","year":"1977","journal-title":"J Exp Med"},{"key":"2022010406280744900_b3","doi-asserted-by":"crossref","first-page":"3268","DOI":"10.1073\/pnas.73.9.3268","article-title":"Control of the amplification convertase of complement by 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