{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:14:56Z","timestamp":1792793696895,"version":"4.5.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2008,1,9]],"date-time":"2008-01-09T00:00:00Z","timestamp":1199836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,1,24]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Chronic active Epstein\u2013Barr virus (EBV) infection (CAEBV) is characterized by chronic recurrent infectious mononucleosis-like symptoms. Approximately one-fourth of CAEBV patients develop vascular lesions with infiltration of EBV-positive lymphoid cells. Furthermore, EBV-positive natural killer (NK)\/T cell lymphomas often exhibit angiocentric or angiodestructive lesions. These suggest an affinity of EBV-positive NK\/T cells to vascular components. In this study, we evaluated the expression of adhesion molecules and cytokines in EBV-positive NK lymphoma cell lines, SNK1 and SNK6, and examined the role of cytokines in the interaction between NK cell lines and endothelial cells. SNKs expressed intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) at much higher levels than those in EBV-negative T cell lines. SNKs produced the larger amount of tumour necrosis factor (TNF)-\u03b1, which caused increased expression of ICAM-1 and VCAM-1 in cultured human endothelial cells, than that from EBV-negative T cell lines. Furthermore, SNKs exhibited increased adhesion to cultured endothelial cells stimulated with TNF-\u03b1 or interleukin (IL)-1\u03b2, and the pretreatment of cytokine-stimulated endothelial cells with anti-VCAM-1-antibodies reduced cell adhesion. These indicate that the up-regulated expression of VCAM-1 on cytokine-stimulated endothelial cells would be important for the adhesion of EBV-positive NK cells and might initiate the vascular lesions.<\/jats:p>","DOI":"10.1111\/j.1365-2249.2007.03584.x","type":"journal-article","created":{"date-parts":[[2010,7,26]],"date-time":"2010-07-26T20:37:47Z","timestamp":1280176667000},"page":"519-527","source":"Crossref","is-referenced-by-count":30,"title":["Adhesion of Epstein\u2013Barr virus-positive natural killer cell lines to cultured endothelial cells stimulated with inflammatory cytokines"],"prefix":"10.1093","volume":"151","author":[{"given":"H","family":"Kanno","sequence":"first","affiliation":[{"name":"Department of Pathology, Iwate Medical University School of Medicine, Morioka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Watabe","sequence":"additional","affiliation":[{"name":"Department of Pathology, Iwate Medical University School of Medicine, Morioka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Virology, Division of Virology and Immunology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Sawai","sequence":"additional","affiliation":[{"name":"Department of Pathology, Iwate Medical University School of Medicine, Morioka"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2008,1,9]]},"reference":[{"key":"2022010406282575600_b1","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1182\/blood.V98.2.280","article-title":"Clinical and virologic characteristics of chronic active Epstein\u2013Barr virus 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