{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T17:50:44Z","timestamp":1789235444418,"version":"build-2803163510"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2008,1,30]],"date-time":"2008-01-30T00:00:00Z","timestamp":1201651200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,2,16]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>The aetiology of idiopathic bronchiectasis, a lung disease where chronic inflammation and bacterial infection leads to progressive lung damage, is unknown. A possible role for natural killer cells has been highlighted previously. However, a role for adaptive immunity is suggested by the presence of CD4 and CD8 T cells in diseased lung tissue. Evidence of a human leucocyte antigen (HLA) class II disease association would further implicate a role for adaptive immunity. To establish if there is any HLA association, we analysed HLA-A, HLA-B, HLA-DQA1, HLA-DQB1 and HLA-DRB1 alleles in patients with idiopathic bronchiectasis and controls. Genomic DNA from 92 adults with idiopathic bronchiectasis and 101 healthy controls was analysed by polymerase chain reaction with sequence-specific primers. We found an increase in the prevalence of HLA-DRB1*01 DQA1*01\/DQB1*05 genes in idiopathic bronchiectasis; that is, the HLA-DR1, DQ5 haplotype (odds ratio 2\u00b719, 95% confidence interval 1\u00b715\u20134\u00b716, P\u2003=\u20030\u00b70152) compared with control subjects. The association with HLA-DR1, DQ5 implicates a role for CD4 T cells restricted by these molecules in susceptibility to the progressive lung damage seen in this disease. This may operate either through influencing susceptibility to specific pathogens or to self-reactivity and requires further investigation.<\/jats:p>","DOI":"10.1111\/j.1365-2249.2008.03596.x","type":"journal-article","created":{"date-parts":[[2010,7,27]],"date-time":"2010-07-27T10:27:52Z","timestamp":1280226472000},"page":"95-101","source":"Crossref","is-referenced-by-count":32,"title":["Human leucocyte antigen class II association in idiopathic bronchiectasis, a disease of chronic lung infection, implicates a role for adaptive immunity"],"prefix":"10.1093","volume":"152","author":[{"given":"R J","family":"Boyton","sequence":"first","affiliation":[{"name":"Lung Immunology Group, NHLI, Sir Alexander Fleming Building, South Kensington Campus, Faculty of Medicine, Imperial College, London"},{"name":"Host Defense Unit, Department of Respiratory Medicine, Royal Brompton and Harefield NHS Trust, London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Smith","sequence":"additional","affiliation":[{"name":"Heart Science Centre, Harefield Hospital, Imperial College, Harefield, Middx"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Jones","sequence":"additional","affiliation":[{"name":"University of Cambridge, Department of Medicine, Addenbrookes Hospital, Cambridge"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Lung Immunology Group, NHLI, Sir Alexander Fleming Building, South Kensington Campus, Faculty of Medicine, Imperial College, London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Ozerovitch","sequence":"additional","affiliation":[{"name":"Host Defense Unit, Department of Respiratory Medicine, Royal Brompton and Harefield NHS Trust, London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Chaudhry","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Medicine, NHLI, Brompton Campus, Imperial College, London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Wilson","sequence":"additional","affiliation":[{"name":"Host Defense Unit, Department of Respiratory Medicine, Royal Brompton and Harefield NHS Trust, London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Rose","sequence":"additional","affiliation":[{"name":"Heart Science Centre, Harefield Hospital, Imperial College, Harefield, Middx"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D M","family":"Altmann","sequence":"additional","affiliation":[{"name":"Human Disease Immunogenetics Group, Department of Infectious Diseases and Immunity, Hammersmith Campus, Imperial College, London, 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