{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T17:06:10Z","timestamp":1761843970117},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2010,4,29]],"date-time":"2010-04-29T00:00:00Z","timestamp":1272499200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,6,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Natural killer T (NK T) cells have been shown to play an essential role in the development of allergen-induced airway hyperresponsiveness (AHR) and\/or airway inflammation in mouse models of acute asthma. Recently, NK T cells have been reported to be required for the development of AHR in a virus induced chronic asthma model. We investigated whether NK T cells were required for the development of allergen-induced AHR, airway inflammation and airway remodelling in a mouse model of chronic asthma. CD1d\u2212\/\u2212 mice that lack NK T cells were used for the experiments. In the chronic model, AHR, eosinophilic inflammation, remodelling characteristics including mucus metaplasia, subepithelial fibrosis and increased mass of the airway smooth muscle, T helper type 2 (Th2) immune response and immunoglobulin (Ig)E production were equally increased in both CD1d\u2212\/\u2212 mice and wild-type mice. However, in the acute model, AHR, eosinophilic inflammation, Th2 immune response and IgE production were significantly decreased in the CD1d\u2212\/\u2212 mice compared to wild-type. CD1d-dependent NK T cells may not be required for the development of allergen-induced AHR, eosinophilic airway inflammation and airway remodelling in chronic asthma model, although they play a role in the development of AHR and eosinophilic inflammation in acute asthma model.<\/jats:p>","DOI":"10.1111\/j.1365-2249.2010.04151.x","type":"journal-article","created":{"date-parts":[[2010,4,30]],"date-time":"2010-04-30T07:54:38Z","timestamp":1272614078000},"page":"159-170","source":"Crossref","is-referenced-by-count":12,"title":["Natural killer T cells are dispensable in the development of allergen-induced airway hyperresponsiveness, inflammation and remodelling in a mouse model of chronic asthma"],"prefix":"10.1093","volume":"161","author":[{"given":"Y-I","family":"Koh","sequence":"first","affiliation":[{"name":"Department of Allergy, Asthma and Clinical Immunology and Research Institute of Medical Sciences, Departments of"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J-U","family":"Shim","sequence":"additional","affiliation":[{"name":"Department of Allergy, Asthma and Clinical Immunology and Research Institute of Medical Sciences, Departments of"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J-H","family":"Lee","sequence":"additional","affiliation":[{"name":"Pathology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I-J","family":"Chung","sequence":"additional","affiliation":[{"name":"Hematology\u2013Oncology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J-J","family":"Min","sequence":"additional","affiliation":[{"name":"Nuclear Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J H","family":"Rhee","sequence":"additional","affiliation":[{"name":"Microbiology, Chonnam National University Medical School, Gwangju"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H C","family":"Lee","sequence":"additional","affiliation":[{"name":"Microbiology, Chonnam National University Medical School, Gwangju"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D H","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Pathology, Seoul National University College of Medicine, Seoul, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J-O","family":"Wi","sequence":"additional","affiliation":[{"name":"Department of Allergy, Asthma and Clinical Immunology and Research Institute of Medical Sciences, Departments of"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2010,4,29]]},"reference":[{"key":"2021122708484643600_b1","first-page":"953","article-title":"A role for natural killer T cells in asthma","volume":"6","author":"Umetsu","year":"2006","journal-title":"Nat 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