{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T03:09:12Z","timestamp":1794366552515,"version":"4.9.0"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2010,5,10]],"date-time":"2010-05-10T00:00:00Z","timestamp":1273449600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,6,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Thymic hypoplasia is a frequent feature of the 22q11.2 deletion syndrome, but we know little about patients' age-related thymic output and long-term consequences for their immune system. We measured the expression of T cell receptor rearrangement excision circles (TREC) and used flow cytometry for direct subtyping of recent thymic emigrant (RTE)-related T cells in 43 patients (aged 1\u201354 years; median 9 years) from all over Norway and in age-matched healthy controls. Thymic volumes were estimated by ultrasound in patients. TREC levels correlated well with RTE-related T cells defined by co-expression of CD3, CD45RA and CCR9 (r = 0\u00b784) as well as with the CD4+ and CD8+ T cell subtypes. RTE-related T cell counts also paralleled age-related TREC reductions. CD45RA+ T cells correlated well with absolute counts of CD4+ (r = 0\u00b787) and CD8+ (r = 0\u00b775) RTE-related T cells. Apart from CD45RA- T cells, all T cell subsets were lower in patients than in controls. Thymic volumes correlated better with RTE-related cells (r = 0\u00b746) than with TREC levels (r = 0\u00b738). RTE-related T cells and TREC levels also correlated well (r = 0\u00b788) in patients without an identifiable thymus. Production of RTEs is impaired in patients with a 22q11.2 deletion, and CCR9 appears to be a good marker for RTE-related T cells.<\/jats:p>","DOI":"10.1111\/j.1365-2249.2010.04152.x","type":"journal-article","created":{"date-parts":[[2010,5,10]],"date-time":"2010-05-10T08:38:30Z","timestamp":1273480710000},"page":"98-107","source":"Crossref","is-referenced-by-count":40,"title":["Low thymic output in the 22q11.2 deletion syndrome measured by CCR9+CD45RA+ T cell counts and T cell receptor rearrangement excision circles"],"prefix":"10.1093","volume":"161","author":[{"given":"K","family":"Lima","sequence":"first","affiliation":[{"name":"Section of Endocrinology, Faculty Division Akershus University Hospital, University of Oslo"},{"name":"Division of Medicine, Akershus University Hospital, Loerenskog"},{"name":"Section for Paediatric Immunology and Infectious Diseases, Division of Paediatrics"},{"name":"Institute of Immunology, Division of Laboratory Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T G","family":"Abrahamsen","sequence":"additional","affiliation":[{"name":"Section for Paediatric Immunology and Infectious Diseases, Division of Paediatrics"},{"name":"Faculty Division Oslo University Hospital, Rikshospitalet, University of Oslo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Foelling","sequence":"additional","affiliation":[{"name":"Section of Endocrinology, Faculty Division Akershus University Hospital, University of Oslo"},{"name":"Division of Medicine, Akershus University Hospital, Loerenskog"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Natvig","sequence":"additional","affiliation":[{"name":"Division of Medical Imaging and Intervention, Department of Radiology, Oslo University Hospital, Rikshospitalet"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L P","family":"Ryder","sequence":"additional","affiliation":[{"name":"Department of Immunology and Transfusion Medicine, Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R W","family":"Olaussen","sequence":"additional","affiliation":[{"name":"Department for Immunology and Transfusion Medicine, Oslo University Hospital, Ullevaal, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,5,10]]},"reference":[{"key":"2021122708484656300_b1","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1016\/0140-6736(92)90734-K","article-title":"Velo-cardio-facial syndrome associated with chromosome 22 deletions encompassing the DiGeorge locus","volume":"339","author":"Scambler","year":"1992","journal-title":"Lancet"},{"key":"2021122708484656300_b2","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1093\/hmg\/2.12.2099","article-title":"Isolation of a putative 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