{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,14]],"date-time":"2026-11-14T00:45:28Z","timestamp":1794617128039,"version":"4.9.1"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2010,7,14]],"date-time":"2010-07-14T00:00:00Z","timestamp":1279065600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,8,16]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>B7-H1 [programmed death-ligand-1 (PD-L1)] is a B7-family member that binds to programmed death-1 (PD-1). Recently, deficiency of PD-L1 has been demonstrated to result in accelerated gastric epithelial cell damage in gastritis, and PD-L1 is suggested to play a critical role in regulating T cell homeostasis. Here, we aimed to gain more insight into gastric PD-L1 expression, regulation and function during Helicobacter pylori infection. PD-L1 expression in human gastric epithelial cells was analysed using Western blotting, quantitative polymerase chain reaction and fluorescence activated cell sorter analysis. Furthermore, co-culture experiments of human gastric epithelial cells with primary human T cells or Jurkat T cells were conducted. PD-L1 expression in primary human gastric epithelial cells was strongly enhanced by H. pylori infection and activated T cells, and augmented markedly by further stimulation with interferon-\u03b3 or tumour necrosis factor-\u03b1. Moreover, PD-L1 expression in gastric epithelial cells significantly induced apoptosis of T cells. Our results indicate that a novel bidirectional interaction between human gastric epithelial cells and lymphocytes modulates PD-L1 expression in human gastric epithelial cells, contributing to the unique immunological properties of the stomach.<\/jats:p>","DOI":"10.1111\/j.1365-2249.2010.04217.x","type":"journal-article","created":{"date-parts":[[2010,7,14]],"date-time":"2010-07-14T14:14:19Z","timestamp":1279116859000},"page":"551-559","source":"Crossref","is-referenced-by-count":87,"title":["Increased programmed death-ligand-1 expression in human gastric epithelial cells in<i>Helicobacter pylori<\/i>infection"],"prefix":"10.1093","volume":"161","author":[{"given":"Y-Y","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Medical Laboratory Science and Biotechnology"},{"name":"Graduate Institute of Clinical Medical Science"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C-W","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Science and Biotechnology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K-S","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, College of Medicine, China Medical University and Hospital, Taichung"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Lin","sequence":"additional","affiliation":[{"name":"Graduate Institute of Clinical Medical Science"},{"name":"Department of Otolaryngology, China Medical University Hospital, Taichung"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y-M","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Science and Biotechnology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I-T","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Science and Biotechnology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y-H","family":"Chou","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Science and Biotechnology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P-N","family":"Hsu","sequence":"additional","affiliation":[{"name":"Graduate Institute of Immunology, College of Medicine, National Taiwan University"},{"name":"Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,7,14]]},"reference":[{"key":"2021122708485979100_b1","first-page":"3620","article-title":"Molecular mechanisms for inflammation-promoted pathogenesis of cancer \u2013 the Sixteenth International Symposium of the Sapporo Cancer Seminar","volume":"57","author":"Parsonnet","year":"1997","journal-title":"Cancer 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