{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T17:32:52Z","timestamp":1744219972252},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2010,9,14]],"date-time":"2010-09-14T00:00:00Z","timestamp":1284422400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,10,8]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Infection with Chlamydia pneumoniae (Cp) accounts for around 10% of community acquired bacterial pneumonia and has been associated with other chronic inflammatory conditions. We describe a C57\/Bl6 murine model of Cp lung infection characterized by a dose-dependent, resolving neutrophilia followed by lymphocytic infiltration of the lungs. By 21 days post-infection, mice exhibit a T helper type 1 (Th1) polarized serum antibody response with local mucosal antibody secretion and organization of ectopic lymphoid tissue which persisted in the absence of detectable Cp DNA. Macrophage inflammatory protein (MIP)-2\/CXCL2, which recruits neutrophils and lymphocytes and is associated with ectopic lymphoid tissue formation, was secreted in the lungs post-infection. In vitro, lung epithelial cells up-regulated MIP-2\/CXCL2 in response to both rough lipopolysaccharide (reLPS) and Cp infection. We conclude that Cp infection can have long-term inflammatory effects on tissue that persist after clearance of active infection.<\/jats:p>","DOI":"10.1111\/j.1365-2249.2010.04231.x","type":"journal-article","created":{"date-parts":[[2010,9,14]],"date-time":"2010-09-14T11:05:53Z","timestamp":1284462353000},"page":"372-378","source":"Crossref","is-referenced-by-count":5,"title":["Ectopic lymphoid tissue formation in the lungs of mice infected with <i>Chlamydia pneumoniae<\/i> is associated with epithelial macrophage inflammatory protein-2\/CXCL2 expression"],"prefix":"10.1093","volume":"162","author":[{"given":"P M","family":"Fitch","sequence":"first","affiliation":[{"name":"University of Edinburgh\/MRC Centre for Inflammation Research"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N M","family":"Wheelhouse","sequence":"additional","affiliation":[{"name":"Moredun Research Institute, Edinburgh, 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