{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T09:29:43Z","timestamp":1791192583349,"version":"4.1.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2011,2,24]],"date-time":"2011-02-24T00:00:00Z","timestamp":1298505600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,4,8]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Immunoglobulin (Ig)D is the major antigen receptor isotype co-expressed with IgM on the surface of most peripheral B cells in mice and humans. However, the biological role of IgD as B cell receptor (BCR) has remained unclear. Previous studies have indicated that IgD may play a role in B cell tolerance. To understand the role of IgD in B cell tolerance and autoimmunity, we have examined the development of autoimmune syndrome in lpr mice deficient for IgD. The present study showed that IgD deficiency did not alter lymphoproliferation and lymphocyte activation in lpr mice. The survival and proliferation of B cells were not affected by the absence of IgD, indicating that IgD BCR-mediated signals do not have an important role in negative selection of autoreactive B cell clones. Interestingly, compared to IgD-competent littermates, lpr mice with IgD deficiency had elevated autoantibody production, increased deposition of immune complex in the kidney and more severe nephritis. Accumulation of abnormal CD4\u2013CD8\u2013\u03b1\u03b2+ T cells was accelerated in IgD\u2212\/\u2212 lpr mice compared to lpr mice. These results suggest that IgD BCR-mediated signals may be involved in the differentiation of autoreactive B cells into plasma cells and abnormal T cell expansion.<\/jats:p>","DOI":"10.1111\/j.1365-2249.2011.04332.x","type":"journal-article","created":{"date-parts":[[2011,2,26]],"date-time":"2011-02-26T09:14:52Z","timestamp":1298711692000},"page":"227-235","source":"Crossref","is-referenced-by-count":19,"title":["The absence of immunoglobulin D B cell receptor-mediated signals promotes the production of autoantibodies and exacerbates glomerulonephritis in murine lupus"],"prefix":"10.1093","volume":"164","author":[{"given":"L","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,2,24]]},"reference":[{"key":"2021122708475528100_b1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1084\/jem.190.1.75","article-title":"B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals","volume":"190","author":"Loder","year":"1999","journal-title":"J Exp Med"},{"key":"2021122708475528100_b2","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1146\/annurev.immunol.15.1.453","article-title":"Initiation and processing of signals from the B cell antigen receptor","volume":"15","author":"Reth","year":"1997","journal-title":"Annu Rev Immunol"},{"key":"2021122708475528100_b3","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1002\/j.1460-2075.1990.tb08130.x","article-title":"Molecular components of the B cell antigen receptor complex of class IgD differ partly from those of IgM","volume":"9","author":"Wienands","year":"1990","journal-title":"EMBO J"},{"key":"2021122708475528100_b4","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/0167-5699(91)90053-V","article-title":"The B-cell antigen receptor complex","volume":"12","author":"Reth","year":"1991","journal-title":"Immunol Today"},{"key":"2021122708475528100_b5","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S1074-7613(00)00003-0","article-title":"Monomeric and oligomeric complexes of the B cell antigen receptor","volume":"13","author":"Schamel","year":"2000","journal-title":"Immunity"},{"key":"2021122708475528100_b6","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1002\/jlb.57.5.703","article-title":"Structure\u2013activity relationships of chemokines","volume":"57","author":"Clark-Lewis","year":"1995","journal-title":"J Leukoc Biol"},{"key":"2021122708475528100_b7","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/356246a0","article-title":"Glycosyl\u2013phosphatidylinositol linkage as a mechanism for cell-surface expression of immunoglobulin D","volume":"356","author":"Wienands","year":"1992","journal-title":"Nature"},{"key":"2021122708475528100_b8","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1038\/ni839","article-title":"A GPI-linked isoform of the IgD receptor regulates resting B cell activation","volume":"3","author":"Chaturvedi","year":"2002","journal-title":"Nat Immunol"},{"key":"2021122708475528100_b9","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1038\/ni.1748","article-title":"Immunoglobulin D enhances immune surveillance by activating antimicrobial, proinflammatory and B cell-stimulating programs in basophils","volume":"10","author":"Chen","year":"2009","journal-title":"Nat Immunol"},{"key":"2021122708475528100_b10","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/j.1600-065X.2010.00929.x","article-title":"New insights into the enigma of immunoglobulin D","volume":"237","author":"Chen","year":"2010","journal-title":"Immunol Rev"},{"key":"2021122708475528100_b11","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/334676a0","article-title":"Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice","volume":"334","author":"Goodnow","year":"1988","journal-title":"Nature"},{"key":"2021122708475528100_b12","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1146\/annurev.iy.01.040183.000341","article-title":"Cellular mechanisms of immunologic tolerance","volume":"1","author":"Nossal","year":"1983","journal-title":"Annu Rev Immunol"},{"key":"2021122708475528100_b13","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1002\/eji.1830121008","article-title":"The relationship between surface immunoglobulin isotype and immune function of murine B lymphocytes. V. IgD-bearing cells in immunological tolerance","volume":"12","author":"Zan-Bar","year":"1982","journal-title":"Eur J Immunol"},{"key":"2021122708475528100_b14","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1002\/eji.1830230127","article-title":"A role for immunoglobulin D: interference with tolerance induction","volume":"23","author":"Carsetti","year":"1993","journal-title":"Eur J Immunol"},{"key":"2021122708475528100_b15","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1084\/jem.181.6.2129","article-title":"Transitional B cells are the target of negative selection in the B cell compartment","volume":"181","author":"Carsetti","year":"1995","journal-title":"J Exp Med"},{"key":"2021122708475528100_b16","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1002\/eji.1830220332","article-title":"Cross-linking of surface IgM or IgD causes differential biological effects in spite of overlap in tyrosine (de)phosphorylation profile","volume":"22","author":"Ales-Martinez","year":"1992","journal-title":"Eur J Immunol"},{"key":"2021122708475528100_b17","doi-asserted-by":"crossref","first-page":"2623","DOI":"10.1002\/1521-4141(200209)32:9<2623::AID-IMMU2623>3.0.CO;2-0","article-title":"A role for membrane IgD in the tolerance of pathological human rheumatoid factor B cells","volume":"32","author":"Soulas","year":"2002","journal-title":"Eur J Immunol"},{"key":"2021122708475528100_b18","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1073\/pnas.90.5.1887","article-title":"Immunoglobulin d-deficient mice can mount normal immune responses to thymus-independent and -dependent antigens","volume":"90","author":"Nitschke","year":"1993","journal-title":"Proc Natl Acad Sci USA"},{"key":"2021122708475528100_b19","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1084\/jem.177.1.45","article-title":"Immunoglobulin D (IgD)-deficient mice reveal an auxiliary receptor function for IgD in antigen-mediated recruitment of B cells","volume":"177","author":"Roes","year":"1993","journal-title":"J Exp Med"},{"key":"2021122708475528100_b20","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1111\/j.1365-2249.2007.03440.x","article-title":"IgM plays an important role in induction of collagen-induced arthritis","volume":"149","author":"Zheng","year":"2007","journal-title":"Clin Exp Immunol"},{"key":"2021122708475528100_b21","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1080\/08916930801931001","article-title":"Exacerbation of autoimmune arthritis by copolymer-I through promoting type 1 immune response and autoantibody production","volume":"41","author":"Zheng","year":"2008","journal-title":"Autoimmunity"},{"key":"2021122708475528100_b22","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1002\/1529-0131(200106)44:6<1438::AID-ART239>3.0.CO;2-Q","article-title":"Germinal center reaction in the joints of mice with collagen-induced arthritis: an animal model of lymphocyte activation and differentiation in arthritis joints. PG-1438-43","volume":"44","author":"Han","year":"2001","journal-title":"Arthritis Rheum"},{"key":"2021122708475528100_b23","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/0090-1229(85)90153-9","article-title":"Interaction of mutant lpr gene with background strain influences renal disease","volume":"37","author":"Kelley","year":"1985","journal-title":"Clin Immunol Immunopathol"},{"key":"2021122708475528100_b24","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.4049\/jimmunol.162.5.2546","article-title":"Cellular and molecular characterization of the scurfy mouse mutant","volume":"162","author":"Clark","year":"1999","journal-title":"J Immunol"},{"key":"2021122708475528100_b25","doi-asserted-by":"crossref","first-page":"4091","DOI":"10.1172\/JCI43873","article-title":"Mammalian target of rapamycin activation underlies HSC defects in autoimmune disease and inflammation in mice","volume":"120","author":"Chen","year":"2010","journal-title":"J Clin Invest"},{"key":"2021122708475528100_b26","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1006\/clim.2002.5225","article-title":"A composite picture of TcR alpha\/beta(+) CD4(\u2013)CD8(\u2013) T Cells (alpha\/beta-DNTCs) in humans with autoimmune lymphoproliferative syndrome","volume":"104","author":"Bleesing","year":"2002","journal-title":"Clin Immunol"},{"key":"2021122708475528100_b27","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1084\/jem.20010955","article-title":"Genetic dissection of SLE: SLE1 and FAS impact alternate pathways leading to lymphoproliferative autoimmunity","volume":"196","author":"Shi","year":"2002","journal-title":"J Exp Med"},{"key":"2021122708475528100_b28","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S0092-8674(00)81108-3","article-title":"Systemic lupus erythematosus","volume":"85","author":"Kotzin","year":"1996","journal-title":"Cell"},{"key":"2021122708475528100_b29","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.immuni.2005.05.010","article-title":"FcgammaRIV: a novel FcR with distinct IgG subclass specificity","volume":"23","author":"Nimmerjahn","year":"2005","journal-title":"Immunity"},{"key":"2021122708475528100_b30","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1084\/jem.20052438","article-title":"TLR9\/MyD88 signaling is required for class switching to pathogenic IgG2a and 2b autoantibodies in SLE","volume":"203","author":"Ehlers","year":"2006","journal-title":"J Exp Med"},{"key":"2021122708475528100_b31","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/nrneph.2010.85","article-title":"C3 glomerulopathy: a new classification","volume":"6","author":"Fakhouri","year":"2010","journal-title":"Nat Rev Nephrol"},{"key":"2021122708475528100_b32","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1002\/eji.200324493","article-title":"IgD+IgM- B cells mount immune responses that exhibit altered antibody repertoire","volume":"34","author":"Han","year":"2004","journal-title":"Eur J Immunol"},{"key":"2021122708475528100_b33","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1146\/annurev.iy.09.040191.001331","article-title":"Lpr and gld: single gene models of systemic autoimmunity and lymphoproliferative disease","volume":"9","author":"Cohen","year":"1991","journal-title":"Annu Rev Immunol"},{"key":"2021122708475528100_b34","doi-asserted-by":"crossref","first-page":"7241","DOI":"10.4049\/jimmunol.162.12.7241","article-title":"A central role for alpha beta T cells in the pathogenesis of murine lupus","volume":"162","author":"Seery","year":"1999","journal-title":"J Immunol"},{"key":"2021122708475528100_b35","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1073\/pnas.85.2.559","article-title":"Exposure to crosslinked IgD induces receptors for IgD on T cells in vivo and in vitro","volume":"85","author":"Coico","year":"1988","journal-title":"Proc Natl Acad Sci USA"},{"key":"2021122708475528100_b36","doi-asserted-by":"crossref","first-page":"3556","DOI":"10.4049\/jimmunol.145.11.3556","article-title":"IgD-receptor-positive human T lymphocytes. I. Modulation of receptor expression by oligomeric IgD and lymphokines","volume":"145","author":"Coico","year":"1990","journal-title":"J Immunol"},{"key":"2021122708475528100_b37","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/0923-2494(90)90110-K","article-title":"Characterization and regulation of T-cell IgD receptors and IgD-binding factor","volume":"141","author":"Amin","year":"1990","journal-title":"Res Immunol"},{"key":"2021122708475528100_b38","doi-asserted-by":"crossref","first-page":"9238","DOI":"10.1073\/pnas.88.20.9238","article-title":"Specificity of the murine IgD receptor on T cells is for N-linked glycans on IgD molecules","volume":"88","author":"Amin","year":"1991","journal-title":"Proc Natl Acad Sci USA"},{"key":"2021122708475528100_b39","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1006\/cimm.2000.1747","article-title":"IgD receptor-mediated signal transduction in T cells","volume":"207","author":"Lakshmi Tamma","year":"2001","journal-title":"Cell Immunol"}],"container-title":["Clinical and Experimental Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2249.2011.04332.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/cei\/article-pdf\/164\/2\/227\/41909655\/j.1365-2249.2011.04332.x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cei\/article-pdf\/164\/2\/227\/41909655\/j.1365-2249.2011.04332.x.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,5]],"date-time":"2023-06-05T08:11:06Z","timestamp":1685952666000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cei\/article\/164\/2\/227\/6429066"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2,24]]},"references-count":39,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2011,2,24]]},"published-print":{"date-parts":[[2011,4,8]]}},"URL":"https:\/\/doi.org\/10.1111\/j.1365-2249.2011.04332.x","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.11003956.11944054","asserted-by":"object"}]},"ISSN":["0009-9104","1365-2249"],"issn-type":[{"value":"0009-9104","type":"print"},{"value":"1365-2249","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2011,5]]},"published":{"date-parts":[[2011,2,24]]}}}