{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T11:30:43Z","timestamp":1770723043710,"version":"3.49.0"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2011,7,15]],"date-time":"2011-07-15T00:00:00Z","timestamp":1310688000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,9,12]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Tumour necrosis factor-like weak inducer of apoptosis (TWEAK), a member of the tumour necrosis factor (TNF) family, has been implicated as a proinflammatory cytokine in many types of autoimmune and infectious diseases. However, information about TWEAK in dermatological diseases is limited. Herein, we investigated the role of TWEAK in patients with Henoch\u2013Schonlein purpura (HSP) and the ability of TWEAK on chemokine production in the human dermal microvascular endothelial cell line (HMEC-1). Serum TWEAK levels in patients with HSP, together with patients with psoriasis vulgaris (PV) and atopic dermatitis (AD), were detected by enzyme-linked immunosorbent assay (ELISA). HMEC-1 cells were treated with TWEAK at concentrations ranging from 1\u2003ng\/ml to 100\u2003ng\/ml. Serum levels of TWEAK were elevated in patients with HSP in the acute stage but not in patients with PV or AD. Moreover, TWEAK levels were correlated with the severity of HSP. TWEAK markedly induced CCL5 and CXCL8 production at both mRNA and protein levels in HMEC-1 cells. In addition, TWEAK-stimulated HMEC-1 supernatant enhanced HL-60 or human acute monocytic leukaemia cell line (THP-1) cell migration. Finally, Western blot data revealed that TWEAK can induce rapid phosphorylation of inhibitor of \u03baB-\u03b1 (I\u03baB\u03b1) in HMEC-1 cells. In conclusion, we show that serum levels of TWEAK were elevated in patients with acute stage HSP. TWEAK may act as a regulator of nuclear factor-\u03baB (NF-\u03baB) activation and chemokine production in human dermal microvascular endothelial cells, thus promoting leucocyte migration in cutaneous vasculitis.<\/jats:p>","DOI":"10.1111\/j.1365-2249.2011.04442.x","type":"journal-article","created":{"date-parts":[[2011,7,15]],"date-time":"2011-07-15T14:23:04Z","timestamp":1310739784000},"page":"64-71","source":"Crossref","is-referenced-by-count":38,"title":["Tumour necrosis factor-like weak inducer of apoptosis (TWEAK), an important mediator of endothelial inflammation, is associated with the pathogenesis of Henoch\u2013Schonlein purpura"],"prefix":"10.1093","volume":"166","author":[{"given":"T","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Dermatovenereology, West China Hospital of Sichuan University, Chengdu, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z-P","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M-M","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatovenereology, West China Hospital of Sichuan University, Chengdu, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J-Y","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatovenereology, West China Hospital of Sichuan University, Chengdu, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X-Y","family":"Jiao","sequence":"additional","affiliation":[{"name":"Department of Dermatovenereology, West China Hospital of Sichuan University, Chengdu, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y-H","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatovenereology, West China Hospital of Sichuan University, Chengdu, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H-J","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Dermatovenereology, West China Hospital of Sichuan University, Chengdu, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2011,7,15]]},"reference":[{"key":"2021122708463669800_b1","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1046\/j.1365-2133.1999.03159.x","article-title":"IgA1 is the major IgA subclass in cutaneous blood vessels in Henoch\u2013Sch\u00f6nlein purpura","volume":"141","author":"Egan","year":"1999","journal-title":"Br J Dermatol"},{"key":"2021122708463669800_b2","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1111\/j.1365-2133.2006.07457.x","article-title":"Elevated serum IgA anticardiolipin antibody levels in adult Henoch\u2013Sch\u00f6nlein 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