{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T03:39:21Z","timestamp":1788061161567,"version":"build-2784847793"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2011,9,12]],"date-time":"2011-09-12T00:00:00Z","timestamp":1315785600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,9,12]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>The prevalence of allergic diseases has increased dramatically during the last four decades and is paralleled by a striking increase in iron intake by infants in affluent societies. Several studies have suggested a link between increased iron intake and the marked increase in prevalence of allergic diseases. We hypothesized that the increased iron intake by infants offers an explanation for the increased prevalence of allergic disease in industrialized societies during the past four decades. A well-established mouse model of ovalbumin (OVA)-driven allergic asthma was used to test the effects of differences in iron intake and systemic iron levels on the manifestations of allergic asthma. Surprisingly, iron supplementation resulted in a significant decrease in airway eosinophilia, while systemic iron injections lead to a significant suppression of both allergen-induced airway eosinophilia and hyperreactivity compared to placebo. In contrast, mice fed on an iron-deprived diet did not show any difference in developing experimentally induced allergic asthma when compared to those fed on an iron-sufficient control diet. In contrast to our hypothesis, airway manifestations of allergic asthma are suppressed by both increased levels of iron intake and systemic iron administrations in the mouse model.<\/jats:p>","DOI":"10.1111\/j.1365-2249.2011.04448.x","type":"journal-article","created":{"date-parts":[[2011,6,30]],"date-time":"2011-06-30T12:16:49Z","timestamp":1309436209000},"page":"80-86","source":"Crossref","is-referenced-by-count":40,"title":["Iron administration reduces airway hyperreactivity and eosinophilia in a mouse model of allergic asthma"],"prefix":"10.1093","volume":"166","author":[{"given":"H","family":"Maazi","sequence":"first","affiliation":[{"name":"Laboratory of Allergology and Pulmonary Diseases, Department of Pathology and Medical Biology, GRIAC Research Institute, University Medical Center Groningen (UMCG), University of Groningen, Groningen, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Shirinbak","sequence":"additional","affiliation":[{"name":"Laboratory of Allergology and Pulmonary Diseases, Department of Pathology and Medical Biology, GRIAC Research Institute, University Medical Center Groningen (UMCG), University of Groningen, Groningen, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Bloksma","sequence":"additional","affiliation":[{"name":"Laboratory of Allergology and Pulmonary Diseases, Department of Pathology and Medical Biology, GRIAC Research Institute, University Medical Center Groningen (UMCG), University of Groningen, Groningen, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M C","family":"Nawijn","sequence":"additional","affiliation":[{"name":"Laboratory of Allergology and Pulmonary Diseases, Department of Pathology and Medical Biology, GRIAC Research Institute, University Medical Center Groningen (UMCG), University of Groningen, Groningen, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A J M","family":"van Oosterhout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,9,12]]},"reference":[{"key":"2021122708464651300_b1","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1056\/NEJMra020100","article-title":"The effect of infections on susceptibility to autoimmune and allergic diseases","volume":"347","author":"Bach","year":"2002","journal-title":"N Engl J Med"},{"key":"2021122708464651300_b2","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1136\/bmj.299.6710.1259","article-title":"Hay fever, hygiene, and household size","volume":"299","author":"Strachan","year":"1989","journal-title":"BMJ"},{"key":"2021122708464651300_b3","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1016\/j.it.2010.02.003","article-title":"Infection, inflammation, and chronic diseases: consequences of a modern lifestyle","volume":"31","author":"Ehlers","year":"2010","journal-title":"Trends Immunol"},{"key":"2021122708464651300_b4","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S0031-3955(08)70033-6","article-title":"Iron and breastfeeding","volume":"48","author":"Griffin","year":"2001","journal-title":"Pediatr Clin North Am"},{"key":"2021122708464651300_b5","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1111\/j.1753-4887.1996.tb03801.x","article-title":"Strategies for the prevention of iron deficiency: iron in infant formulas and baby foods","volume":"54","author":"Ziegler","year":"1996","journal-title":"Nutr Rev"},{"key":"2021122708464651300_b6","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1542\/peds.104.1.119","article-title":"Iron fortification of infant formulas","volume":"104","author":"American Academy of Pediatrics CoN","year":"1999","journal-title":"Pediatrics"},{"key":"2021122708464651300_b7","doi-asserted-by":"crossref","first-page":"2978S","DOI":"10.1093\/jn\/133.9.2978S","article-title":"Iron and ascorbic acid: proposed fortification levels and recommended iron compounds","volume":"133","author":"Lynch","year":"2003","journal-title":"J Nutr"},{"key":"2021122708464651300_b8","first-page":"177","article-title":"\u2018Minor\u2019 hemoglobinopathies: a risk factor for asthma","volume":"37","author":"Palma-Carlos","year":"2005","journal-title":"Allerg Immunol"},{"key":"2021122708464651300_b9","first-page":"462","article-title":"Iron, nitric oxide, and myeloperoxidase in asthmatic patients","volume":"69","author":"Ekmekci","year":"2004","journal-title":"Biochemistry"},{"key":"2021122708464651300_b10","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1111\/j.1365-2249.2003.02372.x","article-title":"Desferrioxamine modulates chemically induced T helper 2-mediated autoimmunity in the rat","volume":"135","author":"Wu","year":"2004","journal-title":"Clin Exp Immunol"},{"key":"2021122708464651300_b11","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/j.1365-2567.2006.02417.x","article-title":"Lactoferrin decreases pollen antigen-induced allergic airway inflammation in a murine model of asthma","volume":"119","author":"Kruzel","year":"2006","journal-title":"Immunology"},{"key":"2021122708464651300_b12","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1086\/516481","article-title":"Iron overload alters innate and T helper cell responses to Candida albicans in mice","volume":"175","author":"Mencacci","year":"1997","journal-title":"J Infect Dis"},{"key":"2021122708464651300_b13","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1111\/j.1469-7793.2000.t01-2-00479.x","article-title":"The effect of serum iron concentration on iron secretion into mouse milk","volume":"1","author":"Zhang","year":"2000","journal-title":"J Physiol"},{"key":"2021122708464651300_b14","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1165\/ajrcmb.25.6.4607","article-title":"CTLA4-IgG reverses asthma manifestations in a mild but not in a more \u2018severe\u2019 ongoing murine model","volume":"25","author":"Deurloo","year":"2001","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2021122708464651300_b15","doi-asserted-by":"crossref","first-page":"3857","DOI":"10.4049\/jimmunol.0903909","article-title":"Suppression of Th2-driven airway inflammation by allergen immunotherapy is independent of B cell and Ig responses in mice","volume":"185","author":"Shirinbak","year":"2010","journal-title":"J Immunol"},{"key":"2021122708464651300_b16","doi-asserted-by":"crossref","first-page":"5211","DOI":"10.4049\/jimmunol.180.8.5211","article-title":"1alpha,25-dihydroxyvitamin D3 potentiates the beneficial effects of allergen immunotherapy in a mouse model of allergic asthma: role for IL-10 and TGF-beta","volume":"180","author":"Taher","year":"2008","journal-title":"J Immunol"},{"key":"2021122708464651300_b17","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0009-8981(96)06489-3","article-title":"The determination of the total iron-binding capacity of serum","volume":"259","author":"Ramsay","year":"1997","journal-title":"Clin Chim Acta"},{"key":"2021122708464651300_b18","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.1093\/clinchem\/43.12.2408","article-title":"The relation between chemically measured total iron-binding capacity concentrations and immunologically measured transferrin concentrations in human serum","volume":"43","author":"Gambino","year":"1997","journal-title":"Clin Chem"},{"key":"2021122708464651300_b19","first-page":"80","volume-title":"Nutrient Requirements of the Mouse. Nutrient Requirements of Laboratory Animals","author":"Subcommittee on Laboratory Animal Nutrition CoANBoANRC","year":"1995","edition":"4th"},{"key":"2021122708464651300_b20","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.1093\/jn\/133.8.2635","article-title":"Iron-deficient mice fail to develop autoimmune encephalomyelitis","volume":"133","author":"Grant","year":"2003","journal-title":"J Nutr"},{"key":"2021122708464651300_b21","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1136\/gut.52.3.340","article-title":"A rapid decrease in the expression of DMT1 and Dcytb but not Ireg1 or hephaestin explains the mucosal block phenomenon of iron absorption","volume":"52","author":"Frazer","year":"2003","journal-title":"Gut"},{"key":"2021122708464651300_b22","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1093\/ajcn\/76.1.198","article-title":"Iron absorption in breast-fed infants: effects of age, iron status, iron supplements, and complementary foods","volume":"76","author":"Domellof","year":"2002","journal-title":"Am J Clin Nutr"},{"key":"2021122708464651300_b23","doi-asserted-by":"crossref","first-page":"7811","DOI":"10.1074\/jbc.M008923200","article-title":"A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload","volume":"276","author":"Pigeon","year":"2001","journal-title":"J Biol Chem"},{"key":"2021122708464651300_b24","volume-title":"Developmental gene expression of lactoferrin and effect of dietary iron on gene regulation of lactoferrin in mouse mammary gland (1525\u20133198)","author":"Wang"},{"key":"2021122708464651300_b25","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1042\/bj2640925","article-title":"Translational regulation of ferritin synthesis in rat liver. Effects of chronic dietary iron overload","volume":"264","author":"Cairo","year":"1989","journal-title":"Biochem J"},{"key":"2021122708464651300_b26","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0014-5793(99)00250-1","article-title":"Iron overload upregulates haem oxygenase 1 in the lung more rapidly than in other tissues","volume":"447","author":"Anning","year":"1999","journal-title":"FEBS Lett"},{"key":"2021122708464651300_b27","doi-asserted-by":"crossref","first-page":"5936","DOI":"10.4049\/jimmunol.177.9.5936","article-title":"Heme oxygenase-1-mediated CD4+CD25high regulatory t cells suppress allergic airway inflammation","volume":"177","author":"Xia","year":"2006","journal-title":"J Immunol"},{"key":"2021122708464651300_b28","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S1369-5274(99)80064-2","article-title":"Immunity to Candida albicans: Th1, Th2 cells and beyond","volume":"2","author":"Romani","year":"1999","journal-title":"Curr Opin Microbiol"},{"key":"2021122708464651300_b29","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1086\/523110","article-title":"Immune recognition of Candida albicans beta-glucan by dectin-1","volume":"196","author":"Gow","year":"2007","journal-title":"J Infect Dis"}],"container-title":["Clinical and Experimental Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2249.2011.04448.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/cei\/article-pdf\/166\/1\/80\/41908917\/j.1365-2249.2011.04448.x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cei\/article-pdf\/166\/1\/80\/41908917\/j.1365-2249.2011.04448.x.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T16:25:54Z","timestamp":1641054354000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cei\/article\/166\/1\/80\/6422847"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9,12]]},"references-count":29,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2011,9,12]]},"published-print":{"date-parts":[[2011,9,12]]}},"URL":"https:\/\/doi.org\/10.1111\/j.1365-2249.2011.04448.x","relation":{},"ISSN":["0009-9104","1365-2249"],"issn-type":[{"value":"0009-9104","type":"print"},{"value":"1365-2249","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2011,10]]},"published":{"date-parts":[[2011,9,12]]}}}