{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T08:34:49Z","timestamp":1789893289432,"version":"4.0.1"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2011,10,10]],"date-time":"2011-10-10T00:00:00Z","timestamp":1318204800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,10,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Eosinophils contribute to the pathogenesis of bullous pemphigoid (BP) by secretion of proinflammatory cytokines and proteases. Trafficking of eosinophils into tissue in animal models and asthma depends on interleukin-5 and a family of chemokines named eotaxins, comprising CCL11, CCL24 and CCL26. Up-regulation of CCL11 has been described in BP, but the expression of the other two members of the eotaxin-family, CCL24 and CCL26, has not been investigated. In addition to these chemokines, expression of adhesion molecules associated with eosinophil migration to the skin should be analysed. We demonstrate that similar to CCL11, the concentration of CCL26 was up-regulated in serum and blister fluid of BP patients. In contrast, the concentration of CCL24 was not elevated in sera and blister fluid of the same BP patients. In lesional skin, CCL11 and CCL26 were detected in epidermis and dermis by immunohistochemistry. In contrast to CCL11, CCL26 was expressed strongly by endothelial cells. In line with these findings, eosinophils represented the dominating cell population in BP lesional skin outnumbering other leucocytes. The percentage of eosinophils expressing very late antigen (VLA): VLA-4 (CD49d) and CD11c correlated with their quantity in tissue. Macrophage antigen (MAC)-1 (CD11b\/CD18) was expressed constitutively by tissue eosinophils. In conclusion, these data link the up-regulation of the eosinophil chemotactic factor CCL26 in BP to the lesional accumulation of activated eosinophils in the skin. Thereby they broaden the understanding of BP pathogenesis and might indicate new options for therapeutic intervention.<\/jats:p>","DOI":"10.1111\/j.1365-2249.2011.04464.x","type":"journal-article","created":{"date-parts":[[2011,8,4]],"date-time":"2011-08-04T12:40:45Z","timestamp":1312461645000},"page":"145-153","source":"Crossref","is-referenced-by-count":50,"title":["Up-regulation of CCL11 and CCL26 is associated with activated eosinophils in bullous pemphigoid"],"prefix":"10.1093","volume":"166","author":[{"given":"C","family":"G\u00fcnther","sequence":"first","affiliation":[{"name":"University Hospital for Dermatology, Technical University Dresden, Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Wozel","sequence":"additional","affiliation":[{"name":"University Hospital for Dermatology, Technical University Dresden, Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Meurer","sequence":"additional","affiliation":[{"name":"University Hospital for Dermatology, Technical University Dresden, Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Pfeiffer","sequence":"additional","affiliation":[{"name":"University Hospital for Dermatology, Technical University Dresden, Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,10,10]]},"reference":[{"key":"2021122708465041000_b1","first-page":"1137","article-title":"Bullous pemphigoid. The latest in diagnosis, prognosis, and therapy","volume":"134","author":"Korman","year":"1998","journal-title":"Arch Dermatol"},{"key":"2021122708465041000_b2","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1001\/jama.1967.03120220053008","article-title":"Basement zone antibodies in bullous pemphigoid","volume":"200","author":"Jordon","year":"1967","journal-title":"JAMA"},{"key":"2021122708465041000_b3","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.4049\/jimmunol.136.4.1231","article-title":"Molecular heterogeneity of the bullous pemphigoid antigens as detected by immunoblotting","volume":"136","author":"Labib","year":"1986","journal-title":"J Immunol"},{"key":"2021122708465041000_b4","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/S0923-1811(02)00109-3","article-title":"BP180 ELISA using bacterial recombinant NC16a protein as a diagnostic and monitoring tool for bullous pemphigoid","volume":"30","author":"Kobayashi","year":"2002","journal-title":"J Dermatol Sci"},{"key":"2021122708465041000_b5","doi-asserted-by":"crossref","first-page":"128","DOI":"10.2302\/kjm.52.128","article-title":"Immunopathology of bullous pemphigoid, an autoimmune and inflammatory skin blistering disease","volume":"52","author":"Liu","year":"2003","journal-title":"Keio J Med"},{"key":"2021122708465041000_b6","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1111\/j.1346-8138.2001.tb00055.x","article-title":"Bullous pemphigoid: end of the century overview","volume":"28","author":"Liu","year":"2001","journal-title":"J Dermatol"},{"key":"2021122708465041000_b7","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1172\/JCI119639","article-title":"A major role for neutrophils in experimental bullous pemphigoid","volume":"100","author":"Liu","year":"1997","journal-title":"J Clin Invest"},{"key":"2021122708465041000_b8","first-page":"897","article-title":"Deposition of eosinophil granule proteins precedes blister formation in bullous pemphigoid. Comparison with neutrophil and mast cell granule proteins","volume":"148","author":"Borrego","year":"1996","journal-title":"Am J Pathol"},{"key":"2021122708465041000_b9","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1172\/JCI117196","article-title":"92-kD gelatinase is produced by eosinophils at the site of blister formation in bullous pemphigoid and cleaves the extracellular domain of recombinant 180-kD bullous pemphigoid autoantigen","volume":"93","author":"Stahle-Backdahl","year":"1994","journal-title":"J Clin Invest"},{"key":"2021122708465041000_b10","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1046\/j.0022-202x.2001.01521.x","article-title":"Respective contribution of neutrophil elastase and matrix metalloproteinase 9 in the degradation of BP180 (type XVII collagen) in human bullous pemphigoid","volume":"117","author":"Verraes","year":"2001","journal-title":"J Invest Dermatol"},{"key":"2021122708465041000_b11","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/j.jaci.2003.08.028","article-title":"Interactions of eosinophil granule proteins with skin: limits of detection, persistence, and vasopermeabilization","volume":"112","author":"Davis","year":"2003","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"2021122708465041000_b12","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1159\/000053587","article-title":"IL-4 induces eotaxin in human dermal fibroblasts","volume":"120","author":"Mochizuki","year":"1999","journal-title":"Int Arch Allergy Immunol"},{"key":"2021122708465041000_b13","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/S0091-6749(99)70069-2","article-title":"Molecular basis for selective eosinophil trafficking in asthma: a multistep paradigm","volume":"104","author":"Wardlaw","year":"1999","journal-title":"J Allergy Clin Immunol"},{"key":"2021122708465041000_b14","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/S0091-6749(03)01798-6","article-title":"Chemokine receptor expression on human eosinophils from peripheral blood and bronchoalveolar lavage fluid after segmental antigen challenge","volume":"112","author":"Liu","year":"2003","journal-title":"J Allergy Clin Immunol"},{"key":"2021122708465041000_b15","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1590\/S0074-02762010000400006","article-title":"Seric chemokines and chemokine receptors in eosinophils during acute human Schistosomiasis mansoni","volume":"105","author":"Silveira-Lemos","year":"2010","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"2021122708465041000_b16","doi-asserted-by":"crossref","first-page":"6190","DOI":"10.4049\/jimmunol.170.12.6190","article-title":"Variations in eosinophil chemokine responses: an investigation of CCR1 and CCR3 function, expression in atopy, and identification of a functional CCR1 promoter","volume":"170","author":"Phillips","year":"2003","journal-title":"J Immunol"},{"key":"2021122708465041000_b17","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1172\/JCI119145","article-title":"Chemokine receptor usage by human eosinophils. The importance of CCR3 demonstrated using an antagonistic monoclonal antibody","volume":"99","author":"Heath","year":"1997","journal-title":"J Clin Invest"},{"key":"2021122708465041000_b18","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1111\/j.1432-1033.1997.00507.x","article-title":"Characterisation of macrophage inflammatory protein-5\/human CC cytokine-2, a member of the macrophage-inflammatory-protein family of chemokines","volume":"248","author":"Coulin","year":"1997","journal-title":"Eur J Biochem"},{"key":"2021122708465041000_b19","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.clim.2006.03.014","article-title":"Increased expression of Th2-associated chemokines in bullous pemphigoid disease. Role of eosinophils in the production and release of these chemokines","volume":"120","author":"Gounni","year":"2006","journal-title":"Clin Immunol"},{"key":"2021122708465041000_b20","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1111\/j.1365-2133.2006.07601.x","article-title":"Serum chemokine profile in patients with bullous pemphigoid","volume":"156","author":"Nakashima","year":"2007","journal-title":"Br J Dermatol"},{"key":"2021122708465041000_b21","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1172\/JCI2688","article-title":"The C-C chemokine receptor CCR3 participates in stimulation of eosinophil arrest on inflammatory endothelium in shear flow","volume":"101","author":"Kitayama","year":"1998","journal-title":"J Clin Invest"},{"key":"2021122708465041000_b22","doi-asserted-by":"crossref","first-page":"6825","DOI":"10.4049\/jimmunol.161.12.6825","article-title":"Interaction of very late antigen-4 with VCAM-1 supports transendothelial chemotaxis of monocytes by facilitating lateral migration","volume":"161","author":"Weber","year":"1998","journal-title":"J Immunol"},{"key":"2021122708465041000_b23","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1046\/j.8755-8920.2003.00118.x","article-title":"Tissue eosinophilia in pemphigoid gestationis: association with eotaxin and upregulated activation markers on transmigrated eosinophils","volume":"51","author":"Gunther","year":"2004","journal-title":"Am J Reprod Immunol"},{"key":"2021122708465041000_b24","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.4049\/jimmunol.163.3.1602","article-title":"A novel human CC chemokine, eotaxin-3, which is expressed in IL-4-stimulated vascular endothelial cells, exhibits potent activity toward eosinophils","volume":"163","author":"Shinkai","year":"1999","journal-title":"J Immunol"},{"key":"2021122708465041000_b25","first-page":"27","article-title":"Increased expression of eotaxin and its specific receptor CCR3 in bullous pemphigoid","volume":"12","author":"Frezzolini","year":"2002","journal-title":"Eur J Dermatol"},{"key":"2021122708465041000_b26","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1080\/000155500750012162","article-title":"Increased coexpression of eotaxin and interleukin 5 in bullous pemphigoid","volume":"80","author":"Shrikhande","year":"2000","journal-title":"Acta Derm Venereol"},{"key":"2021122708465041000_b27","doi-asserted-by":"crossref","first-page":"81","DOI":"10.2174\/1568010033344480","article-title":"Eotaxins and CCR3 receptor in inflammatory and allergic skin diseases: therapeutical implications","volume":"2","author":"Amerio","year":"2003","journal-title":"Curr Drug Targets Inflamm Allergy"},{"key":"2021122708465041000_b28","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/nm0496-449","article-title":"Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia","volume":"2","author":"Garcia-Zepeda","year":"1996","journal-title":"Nat Med"},{"key":"2021122708465041000_b29","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.bbrc.2008.08.136","article-title":"Enhanced CCL26 production by IL-4 through IFN-gamma-induced upregulation of type 1 IL-4 receptor in keratinocytes","volume":"376","author":"Nishi","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"2021122708465041000_b30","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1111\/j.1365-2249.2005.02875.x","article-title":"Interleukin-4 and interleukin-13 enhance CCL26 production in a human keratinocyte cell line, HaCaT cells","volume":"141","author":"Kagami","year":"2005","journal-title":"Clin Exp Immunol"},{"key":"2021122708465041000_b31","doi-asserted-by":"crossref","first-page":"2748","DOI":"10.4049\/jimmunol.165.5.2748","article-title":"CCR3-active chemokines promote rapid detachment of eosinophils from VCAM-1 in vitro","volume":"165","author":"Tachimoto","year":"2000","journal-title":"J Immunol"},{"key":"2021122708465041000_b32","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1046\/j.1365-2249.2003.02273.x","article-title":"Significant elevation of serum levels of eotaxin-3\/CCL26, but not of eotaxin-2\/CCL24, in patients with atopic dermatitis: serum eotaxin-3\/CCL26 levels reflect the disease activity of atopic dermatitis","volume":"134","author":"Kagami","year":"2003","journal-title":"Clin Exp Immunol"},{"key":"2021122708465041000_b33","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1093\/rheumatology\/ken033","article-title":"Eotaxin-3 is involved in Churg\u2013Strauss syndrome\u2003\u2013\u2003a serum marker closely correlating with disease activity","volume":"47","author":"Polzer","year":"2008","journal-title":"Rheumatology (Oxf)"},{"key":"2021122708465041000_b34","doi-asserted-by":"crossref","first-page":"547","DOI":"10.4269\/ajtmh.2007.77.547","article-title":"Differentiation of patients with leprosy from non-infected individuals by the chemokine eotaxin\/CCL11","volume":"77","author":"Mendonca","year":"2007","journal-title":"Am J Trop Med Hyg"},{"key":"2021122708465041000_b35","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.cyto.2004.03.013","article-title":"High level expression, activation, and antagonism of CC chemokine receptors CCR2 and CCR3 in Chinese hamster ovary cells","volume":"27","author":"Parody","year":"2004","journal-title":"Cytokine"},{"key":"2021122708465041000_b36","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1021\/bi101240v","article-title":"Tyrosine sulfation influences the chemokine binding selectivity of peptides derived from chemokine receptor CCR3","volume":"50","author":"Zhu","year":"2011","journal-title":"Biochemistry"},{"key":"2021122708465041000_b37","doi-asserted-by":"crossref","first-page":"27935","DOI":"10.1074\/jbc.M703255200","article-title":"Small molecule receptor agonists and antagonists of CCR3 provide insight into mechanisms of chemokine receptor activation","volume":"282","author":"Wise","year":"2007","journal-title":"J Biol Chem"},{"key":"2021122708465041000_b38","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/j.1747-0285.2011.01088.x","article-title":"First pharmacophore model of CCR3 receptor antagonists and its homology model-assisted, stepwise virtual screening","volume":"77","author":"Jain","year":"2011","journal-title":"Chem Biol Drug Des"},{"issue":"1","key":"2021122708465041000_b39","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1159\/000237204","article-title":"Possible release of eosinophil granule proteins in response to signaling from intercellular adhesion molecule-1 and its ligands","volume":"108","author":"Chihara","year":"1995","journal-title":"Int Arch Allergy Immunol"},{"key":"2021122708465041000_b40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1189\/jlb.0607344","article-title":"Roles of integrin activation in eosinophil function and the eosinophilic inflammation of asthma","volume":"83","author":"Barthel","year":"2008","journal-title":"J Leukoc Biol"},{"key":"2021122708465041000_b41","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.0906-6705.2004.00113.x","article-title":"Altered tissue expression pattern of cell adhesion molecules, ICAM-1, E-selectin and VCAM-1, in bullous pemphigoid during methotrexate therapy","volume":"13","author":"Dahlman-Ghozlan","year":"2004","journal-title":"Exp Dermatol"},{"key":"2021122708465041000_b42","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1007\/s004280100507","article-title":"Expression of adhesion molecules in allergic lung diseases","volume":"440","author":"Popper","year":"2002","journal-title":"Virchows Arch"},{"key":"2021122708465041000_b43","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1111\/j.1365-2222.2005.02296.x","article-title":"Effect of a very late antigen-4 receptor antagonist on allergen-induced airway responses and inflammation in asthma","volume":"35","author":"Diamant","year":"2005","journal-title":"Clin Exp Allergy"},{"key":"2021122708465041000_b44","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1183\/09031936.03.00102002","article-title":"Endothelial cells modulate eosinophil surface markers and mediator release","volume":"21","author":"Dallaire","year":"2003","journal-title":"Eur Respir J"},{"key":"2021122708465041000_b45","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1159\/000023891","article-title":"Eosinophil granulocyte interaction with serum-opsonized particles: binding and degranulation are enhanced by tumor necrosis factor alpha","volume":"115","author":"Egesten","year":"1998","journal-title":"Int Arch Allergy Immunol"},{"key":"2021122708465041000_b46","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1023\/A:1006940109869","article-title":"The impact of eotaxin- and IL-5-induced adhesion and transmigration on eosinophil activity markers","volume":"24","author":"Fernvik","year":"2000","journal-title":"Inflammation"},{"key":"2021122708465041000_b47","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1023\/A:1022379821130","article-title":"Eotaxin increases the expression of CD11b\/CD18 and adhesion properties in IL5, but not fMLP-prestimulated human peripheral blood eosinophils","volume":"22","author":"Lundahl","year":"1998","journal-title":"Inflammation"},{"key":"2021122708465041000_b48","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s12016-007-0030-y","article-title":"The pathophysiology of bullous pemphigoid","volume":"33","author":"Kasperkiewicz","year":"2007","journal-title":"Clin Rev Allergy Immunol"},{"key":"2021122708465041000_b49","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1084\/jem.164.6.2125","article-title":"Regional variations in antigenic properties of skin. A possible cause for disease-specific distribution of skin lesions","volume":"164","author":"Sison-Fonacier","year":"1986","journal-title":"J Exp Med"},{"key":"2021122708465041000_b50","first-page":"76","article-title":"Relationship between theoretical molecular weight and blister fluid\/serum ratio of cytokines and five other molecules evaluated in patients with bullous pemphigoid","volume":"12","author":"D'Auria","year":"1998","journal-title":"J Biol Regul Homeost Agents"},{"key":"2021122708465041000_b51","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1084\/jem.181.6.2119","article-title":"C3a is a chemotaxin for human eosinophils but not for neutrophils. I. C3a stimulation of neutrophils is secondary to eosinophil activation","volume":"181","author":"Daffern","year":"1995","journal-title":"J Exp Med"},{"key":"2021122708465041000_b52","doi-asserted-by":"crossref","first-page":"18","DOI":"10.2340\/00015555-0759","article-title":"Indomethacin-induced reduction in CRTH2 in eosinophilic pustular folliculitis (Ofuji's disease): a proposed mechanism of action","volume":"90","author":"Satoh","year":"2010","journal-title":"Acta Derm Venereol"},{"key":"2021122708465041000_b53","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1046\/j.1365-2133.1999.02907.x","article-title":"Characterization of skin cytokines in bullous pemphigoid and pemphigus vulgaris","volume":"140","author":"Rico","year":"1999","journal-title":"Br J Dermatol"},{"key":"2021122708465041000_b54","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1002\/eji.200323787","article-title":"CCR3 functional responses are regulated by both CXCR3 and its ligands CXCL9, CXCL10 and CXCL11","volume":"33","author":"Xanthou","year":"2003","journal-title":"Eur J Immunol"},{"key":"2021122708465041000_b55","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1046\/j.1365-2133.2003.05066.x","article-title":"High level of thymus and activation-regulated chemokine in blister fluid and sera of patients with bullous pemphigoid","volume":"148","author":"Kakinuma","year":"2003","journal-title":"Br J Dermatol"},{"key":"2021122708465041000_b56","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.4049\/jimmunol.164.3.1488","article-title":"C-C chemokine receptor 3 antagonism by the beta-chemokine macrophage inflammatory protein 4, a property strongly enhanced by an amino-terminal alanine\u2013methionine swap","volume":"164","author":"Nibbs","year":"2000","journal-title":"J Immunol"},{"key":"2021122708465041000_b57","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1111\/j.1365-2133.2008.08979.x","article-title":"CCL18 is expressed in patients with bullous pemphigoid and parallels disease course","volume":"160","author":"Gunther","year":"2009","journal-title":"Br J Dermatol"},{"key":"2021122708465041000_b58","doi-asserted-by":"crossref","first-page":"23357","DOI":"10.1074\/jbc.M309283200","article-title":"Eotaxin-3\/CCL26 is a natural antagonist for CC chemokine receptors 1 and 5. A human chemokine with a regulatory role","volume":"279","author":"Petkovic","year":"2004","journal-title":"J Biol Chem"}],"container-title":["Clinical and Experimental Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2249.2011.04464.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/cei\/article-pdf\/166\/2\/145\/41908473\/j.1365-2249.2011.04464.x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cei\/article-pdf\/166\/2\/145\/41908473\/j.1365-2249.2011.04464.x.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T15:30:47Z","timestamp":1712676647000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cei\/article\/166\/2\/145\/6422896"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10,10]]},"references-count":58,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2011,10,10]]},"published-print":{"date-parts":[[2011,10,10]]}},"URL":"https:\/\/doi.org\/10.1111\/j.1365-2249.2011.04464.x","relation":{},"ISSN":["0009-9104","1365-2249"],"issn-type":[{"value":"0009-9104","type":"print"},{"value":"1365-2249","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2011,11]]},"published":{"date-parts":[[2011,10,10]]}}}