{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T09:13:15Z","timestamp":1784193195949,"version":"3.55.0"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2012,1,11]],"date-time":"2012-01-11T00:00:00Z","timestamp":1326240000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,1,11]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Abnormalities in peripheral blood B cell subsets have been identified in common variable immunodeficiency (CVID) patients and classification systems based upon their numbers have been proposed to predict the clinical features. We analysed B lymphocyte subsets by multi-colour flow cytometry (MFC) in a cohort of well-characterized CVID patients to look at their clinical relevance and validate the published association of different classification criteria (Freiburg, Paris and Euroclass) with clinical manifestations. CVID patients had a reduced proportion of total and switched memory B cells (MBC, swMBC) compared to normal controls (P\u2003&amp;lt;\u20030\u00b70006). Patients classified in Freiburg Ia had a higher prevalence of granulomatous diseases (P\u2003=\u20030\u00b70034). The previously published associations with autoimmune diseases could not be confirmed. The Euroclass classification was not predictive of clinical phenotypes. The absolute numbers of all B cell subsets were reduced in CVID patients compared to controls. There was a significant linear correlation between low absolute total B cells and MBC with granulomatous disease (P\u2003&amp;lt;\u20030\u00b705) and a trend towards lower B cells in patients with autoimmune diseases (P\u2003=\u20030\u00b707). Absolute number of different B cell subsets may be more meaningful than their relative percentages in assessing the risk of granulomatous diseases and possibly autoimmunity.<\/jats:p>","DOI":"10.1111\/j.1365-2249.2011.04507.x","type":"journal-article","created":{"date-parts":[[2011,10,18]],"date-time":"2011-10-18T15:31:15Z","timestamp":1318951875000},"page":"275-281","source":"Crossref","is-referenced-by-count":27,"title":["Utility of peripheral blood B cell subsets analysis in common variable immunodeficiency"],"prefix":"10.1093","volume":"167","author":[{"given":"M","family":"Al Kindi","sequence":"first","affiliation":[{"name":"Division of Human Immunology, SA Pathology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Mundy","sequence":"additional","affiliation":[{"name":"Division of Human Immunology, SA Pathology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Sullivan","sequence":"additional","affiliation":[{"name":"Data Management & Analysis Centre, University of Adelaide"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W","family":"Smith","sequence":"additional","affiliation":[{"name":"Clinical Immunology Unit, Royal Adelaide Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Kette","sequence":"additional","affiliation":[{"name":"Clinical Immunology Unit, Royal Adelaide Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Smith","sequence":"additional","affiliation":[{"name":"Immunology and Allergy Unit, Flinders Medical Centre, Bedford Park, Adelaide, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Heddle","sequence":"additional","affiliation":[{"name":"Division of Human Immunology, SA Pathology"},{"name":"Clinical Immunology Unit, Royal Adelaide Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Hissaria","sequence":"additional","affiliation":[{"name":"Division of Human Immunology, SA Pathology"},{"name":"Clinical Immunology Unit, Royal Adelaide Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,1,11]]},"reference":[{"key":"2021122708455997600_b1","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1006\/clim.1999.4799","article-title":"Diagnostic criteria for primary immunodeficiencies. 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