{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T16:29:01Z","timestamp":1791044941189,"version":"4.1.0"},"reference-count":65,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2012,1,11]],"date-time":"2012-01-11T00:00:00Z","timestamp":1326240000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,1,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>In this study, we investigated the role and expression of T helper type 17 (Th17) cells and Th17 cytokines in human tuberculosis. We show that the basal proportion of interferon (IFN)-\u03b3-, interleukin (IL)-17- and IL-22-expressing CD4+ T cells and IL-22-expressing granulocytes in peripheral blood were significantly lower in latently infected healthy individuals and active tuberculosis patients compared to healthy controls. In contrast, CD4+ T cells expressing IL-17, IL-22 and IFN-\u03b3 were increased significantly following mycobacterial antigens stimulation in both latent and actively infected patients. Interestingly, proinflammatory IFN-\u03b3 and tumour necrosis factor (TNF)-\u03b1 were increased following antigen stimulation in latent infection. Similarly, IL-1\u03b2, IL-4, IL-8, IL-22 and TNF-\u03b1 were increased in the serum of latently infected individuals, whereas IL-6 and TNF-\u03b1 were increased significantly in actively infected patients. Overall, we observed differential induction of IL-17-, IL-22- and IFN-\u03b3-expressing CD4+ T cells, IL-22-expressing granulocytes and proinflammatory cytokines in circulation and following antigenic stimulation in latent and active tuberculosis.<\/jats:p>","DOI":"10.1111\/j.1365-2249.2011.04520.x","type":"journal-article","created":{"date-parts":[[2011,11,10]],"date-time":"2011-11-10T06:32:31Z","timestamp":1320906751000},"page":"317-329","source":"Crossref","is-referenced-by-count":62,"title":["Comparison of interferon-\u03b3-, interleukin (IL)-17- and IL-22-expressing CD4 T cells, IL-22-expressing granulocytes and proinflammatory cytokines during latent and active tuberculosis infection"],"prefix":"10.1093","volume":"167","author":[{"given":"J","family":"Cowan","sequence":"first","affiliation":[{"name":"Ottawa Hospital Research Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Pandey","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, University of Ottawa, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L G","family":"Filion","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Microbiology and Immunology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J B","family":"Angel","sequence":"additional","affiliation":[{"name":"Ottawa Hospital Research Institute"},{"name":"Department of Biochemistry, Microbiology and Immunology"},{"name":"Division of Infectious Diseases, University of Ottawa at The Ottawa Hospital, Ottawa, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Microbiology and Immunology"},{"name":"Department of Pathology, Faculty of Medicine, University of Ottawa, Canada"},{"name":"Infectious Disease and Vaccine Research Center, Children's Hospital of Eastern Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D W","family":"Cameron","sequence":"additional","affiliation":[{"name":"Ottawa Hospital Research Institute"},{"name":"Department of Biochemistry, Microbiology and Immunology"},{"name":"Division of Infectious Diseases, University of Ottawa at The Ottawa Hospital, Ottawa, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,1,11]]},"reference":[{"key":"2021122708460372600_b1","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1001\/jama.282.7.677","article-title":"Consensus statement. 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