{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:47:23Z","timestamp":1791294443945,"version":"4.1.0"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2012,3,2]],"date-time":"2012-03-02T00:00:00Z","timestamp":1330646400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,3,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>We characterized the underlying mechanisms by which glutathione (GSH)-enhanced natural killer (NK) cells inhibit the growth of Mycobacterium tuberculosis (M.\u2003tb) inside human monocytes. We observed that in healthy individuals, treatment of NK cells with N-acetyl cysteine (NAC), a GSH prodrug in conjunction with cytokines such as interleukin (IL)-2\u2003+\u2003IL-12, resulted in enhanced expression of NK cytotoxic ligands (FasL and CD40L) with concomitant stasis in the intracellular growth of M.\u2003tb. Neutralization of FasL and CD40L in IL-2\u2003+\u2003IL-12\u2003+\u2003NAC-treated NK cells resulted in abrogation in the growth inhibition of M.\u2003tb inside monocytes. Importantly, we observed that the levels of GSH are decreased significantly in NK cells derived from individuals with HIV infection compared to healthy subjects, and this decrease correlated with a several-fold increase in the growth of M.\u2003tb inside monocytes. This study describes a novel innate defence mechanism adopted by NK cells to control M.\u2003tb infection.<\/jats:p>","DOI":"10.1111\/j.1365-2249.2011.04552.x","type":"journal-article","created":{"date-parts":[[2011,12,28]],"date-time":"2011-12-28T21:54:44Z","timestamp":1325109284000},"page":"142-152","source":"Crossref","is-referenced-by-count":70,"title":["Control of<i>Mycobacterium tuberculosis<\/i>growth by activated natural killer cells"],"prefix":"10.1093","volume":"168","author":[{"given":"C","family":"Guerra","sequence":"first","affiliation":[{"name":"College of Osteopathic Medicine of the Pacific"},{"name":"Western University of Health Sciences, Pomona, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Johal","sequence":"additional","affiliation":[{"name":"College of Osteopathic Medicine of the Pacific"},{"name":"Western University of Health Sciences, Pomona, CA, 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