{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:11:30Z","timestamp":1761513090181},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2012,4,3]],"date-time":"2012-04-03T00:00:00Z","timestamp":1333411200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,4,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Systemic lupus erythematosus (SLE) is a polygenic autoimmune disease characterized by the production of anti-nuclear autoantibodies that lead to subsequent end organ damage. Previous array-based studies in patients with SLE have shown that high immunoglobulin (Ig)G anti-nuclear autoantibody reactivity was associated with severe renal lupus, whereas IgM polyreactivity was associated with less severe disease. To ascertain how different murine lupus strains recapitulate these different autoantibody profiles seen in patients, serum from New Zealand black (NZB)\/NZ white (W) F1, Murphy Roths large (MRL)\/lpr, NZ mixed (M)2410 and BXSB strains were compared using a comprehensive array-based screen. The array results were verified using enzyme-linked immunosorbent assays (ELISAs). Serum from MRL\/lpr mice exhibited high levels of IgG anti-nuclear antibodies as well as anti-glomerular antibodies and variable levels of antibodies to myosin, Matrigel and thyroglobulin. Elevated anti-nuclear IgG antibodies were associated with severe nephritis in this strain. In contrast, NZM2410 mice exhibited lower IgG autoantibody levels with less severe nephritis but a significantly higher polyreactive IgM autoantibody profile. ELISA analysis confirmed these results. The NZB\/NZW F1 and BXSB strains exhibited an intermediate serological profile. Hence, just as in patients with SLE, whereas strong IgG reactivity to nuclear antigens is associated with severe renal disease, a polyreactive IgM seroprofile is also less ominous in murine lupus.<\/jats:p>","DOI":"10.1111\/j.1365-2249.2012.04568.x","type":"journal-article","created":{"date-parts":[[2012,2,2]],"date-time":"2012-02-02T03:31:30Z","timestamp":1328153490000},"page":"178-185","source":"Crossref","is-referenced-by-count":16,"title":["Murine lupus strains differentially model unique facets of human lupus serology"],"prefix":"10.1093","volume":"168","author":[{"given":"L","family":"Li","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Immunology, University of Texas Southwestern Medical Center, Dallas, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Nukala","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Immunology, University of Texas Southwestern Medical Center, Dallas, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Immunology, University of Texas Southwestern Medical Center, Dallas, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Immunology, University of Texas Southwestern Medical Center, Dallas, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Immunology, University of Texas Southwestern Medical Center, Dallas, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Hutcheson","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Immunology, University of Texas Southwestern Medical Center, Dallas, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Pathak","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Immunology, University of Texas Southwestern Medical Center, Dallas, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Q","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Immunology, University of Texas Southwestern Medical Center, Dallas, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Mohan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Immunology, University of Texas Southwestern Medical Center, Dallas, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2012,4,3]]},"reference":[{"key":"2021122708380996200_b1","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1056\/NEJMoa021933","article-title":"Development of autoantibodies before the clinical onset of systemic lupus erythematosus","volume":"349","author":"Arbuckle","year":"2003","journal-title":"N Engl J Med"},{"key":"2021122708380996200_b2","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1084\/jem.152.5.1302","article-title":"Mechanisms of autoantibody production in autoimmune MRL mice","volume":"152","author":"Pisetsky","year":"1980","journal-title":"J Exp Med"},{"key":"2021122708380996200_b3","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0090-1229(84)90190-9","article-title":"The influence of the lpr gene on B cell activation: differential antibody expression in lpr congenic mouse strains","volume":"31","author":"Warren","year":"1984","journal-title":"Clin Immunol Immunopathol"},{"key":"2021122708380996200_b4","doi-asserted-by":"crossref","first-page":"3428","DOI":"10.1172\/JCI23587","article-title":"Identification of autoantibody clusters that best predict lupus disease activity using glomerular autoantigen arrays","volume":"115","author":"Li","year":"2005","journal-title":"J Clin Invest"},{"key":"2021122708380996200_b5","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/j.1365-2249.2006.03251.x","article-title":"Autoantigen array autoantibody profiles for insights into systemic lupus erythematosus and incomplete lupus syndromes","volume":"147","author":"Li","year":"2007","journal-title":"Clin Exp Immunol"},{"key":"2021122708380996200_b6","doi-asserted-by":"crossref","first-page":"5047","DOI":"10.4049\/jimmunol.172.8.5047","article-title":"Strain distribution pattern of susceptibility to immune-mediated nephritis","volume":"172","author":"Xie","year":"2004","journal-title":"J Immunol"},{"key":"2021122708380996200_b7","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1084\/jem.177.5.1367","article-title":"Nucleosomes: a major immunogen for pathogenic autoantibody-inducing T cells of lupus","volume":"177","author":"Mohan","year":"1993","journal-title":"J Exp Med"},{"key":"2021122708380996200_b8","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1172\/JCI5827","article-title":"Genetic dissection of SLE pathogenesis: a recipe for nephrophilic autoantibodies","volume":"103","author":"Mohan","year":"1999","journal-title":"J Clin Invest"},{"key":"2021122708380996200_b9","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1002\/art.10887","article-title":"Enhanced intrinsic susceptibility to renal disease in the lupus facilitating NZW strain","volume":"48","author":"Xie","year":"2003","journal-title":"Arthritis Rheum"},{"key":"2021122708380996200_b10","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1038\/labinvest.3780200","article-title":"Association of renal injury with increased oxygen free radical activity and altered nitric oxide metabolism in chronic experimental hemosiderosis","volume":"80","author":"Zhou","year":"2000","journal-title":"Lab Invest"},{"key":"2021122708380996200_b11","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1084\/jem.20030132","article-title":"Pathogenic profiles and molecular signatures of antinuclear autoantibodies rescued from NZM2410 lupus mice","volume":"199","author":"Liang","year":"2004","journal-title":"J Exp Med"},{"key":"2021122708380996200_b12","doi-asserted-by":"crossref","first-page":"454","DOI":"10.4049\/jimmunol.159.1.454","article-title":"Genetic dissection of systemic lupus erythematosus pathogenesis: Sle2 on murine chromosome 4 leads to B cell hyperactivity","volume":"159","author":"Mohan","year":"1997","journal-title":"J Immunol"},{"key":"2021122708380996200_b13","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0065-2776(08)60342-9","article-title":"Murine models of systemic lupus erythematosus","volume":"37","author":"Theofilopoulos","year":"1985","journal-title":"Adv Immunol"},{"key":"2021122708380996200_b14","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1002\/art.30230","article-title":"Activation-induced deaminase- deficient MRL\/lpr mice secrete high levels of protective antibodies against lupus nephritis","volume":"63","author":"Jiang","year":"2011","journal-title":"Arthritis Rheum"},{"key":"2021122708380996200_b15","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0022-1759(91)90083-R","article-title":"Increased yields of IgG2a- and IgG3-secreting hybridomas after fusion of B cells from mice with autoimmune diseases","volume":"144","author":"Yin","year":"1991","journal-title":"J Immunol Methods"},{"key":"2021122708380996200_b16","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/BF00351164","article-title":"Autoantibody to the nucleosome subunit (H2A\u2013H2B)\u2013DNA is an early and ubiquitous feature of lupus-like conditions","volume":"23","author":"Burlingame","year":"1996","journal-title":"Mol Biol Rep"},{"key":"2021122708380996200_b17","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.4049\/jimmunol.154.5.2483","article-title":"IgG but not other classes of anti-[(H2A\u2013H2B)\u2013DNA] is an early sign of procainamide-induced lupus","volume":"154","author":"Rubin","year":"1995","journal-title":"J Immunol"},{"key":"2021122708380996200_b18","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1007\/BF02054252","article-title":"AutoANA in systemic lupus erythematosus and normal subjects","volume":"5","author":"Pateraki","year":"1986","journal-title":"Clin Rheumatol"},{"key":"2021122708380996200_b19","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1172\/JCI115353","article-title":"Drug-induced anti-histone autoantinuclear autoantibodies display two patterns of reactivity with substructures of chromatin","volume":"88","author":"Burlingame","year":"1991","journal-title":"J Clin Invest"},{"key":"2021122708380996200_b20","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1111\/j.1365-2567.2010.03245.x","article-title":"An antibody profile of systemic lupus erythematosus detected by antigen microarray","volume":"130","author":"Fattal","year":"2010","journal-title":"Immunology"}],"container-title":["Clinical and Experimental Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2249.2012.04568.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/cei\/article-pdf\/168\/2\/178\/41907268\/j.1365-2249.2012.04568.x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cei\/article-pdf\/168\/2\/178\/41907268\/j.1365-2249.2012.04568.x.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T07:24:19Z","timestamp":1686727459000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cei\/article\/168\/2\/178\/6428894"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,3]]},"references-count":20,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2012,4,3]]},"published-print":{"date-parts":[[2012,4,3]]}},"URL":"https:\/\/doi.org\/10.1111\/j.1365-2249.2012.04568.x","relation":{},"ISSN":["0009-9104","1365-2249"],"issn-type":[{"value":"0009-9104","type":"print"},{"value":"1365-2249","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2012,5]]},"published":{"date-parts":[[2012,4,3]]}}}