{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:07:01Z","timestamp":1791328021502,"version":"4.3.1"},"reference-count":136,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2012,12,3]],"date-time":"2012-12-03T00:00:00Z","timestamp":1354492800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,12,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>T cells reactive to lipids and restricted by major histocompatibility complex (MHC) class I-like molecules represent more than 15% of all lymphocytes in human blood. This heterogeneous population of innate cells includes the invariant natural killer T cells (iNK\u2003T), type II NK\u2003T cells, CD1a,b,c-restricted T cells and mucosal-associated invariant T (MAIT) cells. These populations are implicated in cancer, infection and autoimmunity. In this review, we focus on the role of these cells in autoimmunity. We summarize data obtained in humans and preclinical models of autoimmune diseases such as primary biliary cirrhosis, type 1 diabetes, multiple sclerosis, systemic lupus erythematosus, rheumatoid arthritis, psoriasis and atherosclerosis. We also discuss the promise of NK\u2003T cell manipulations: restoration of function, specific activation, depletion and the relevance of these treatments to human autoimmune diseases.<\/jats:p>","DOI":"10.1111\/j.1365-2249.2012.04625.x","type":"journal-article","created":{"date-parts":[[2012,6,22]],"date-time":"2012-06-22T20:38:21Z","timestamp":1340397501000},"page":"8-19","source":"Crossref","is-referenced-by-count":87,"title":["Therapeutic manipulation of natural killer (NK)\u2003T cells in autoimmunity: are we close to reality?"],"prefix":"10.1093","volume":"171","author":[{"given":"Y","family":"Simoni","sequence":"first","affiliation":[{"name":"INSERM, U986, Hospital Cochin\/St Vincent de Paul, Universit\u00e9 Paris Descartes, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Diana","sequence":"additional","affiliation":[{"name":"INSERM, U986, Hospital Cochin\/St Vincent de Paul, Universit\u00e9 Paris Descartes, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Ghazarian","sequence":"additional","affiliation":[{"name":"INSERM, U986, Hospital Cochin\/St Vincent de Paul, Universit\u00e9 Paris Descartes, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Beaudoin","sequence":"additional","affiliation":[{"name":"INSERM, U986, Hospital Cochin\/St Vincent de Paul, Universit\u00e9 Paris Descartes, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Lehuen","sequence":"additional","affiliation":[{"name":"INSERM, U986, Hospital Cochin\/St Vincent de Paul, Universit\u00e9 Paris Descartes, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,12,3]]},"reference":[{"key":"2021122009520913600_b1","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nri1309","article-title":"NKT cells: what's in a 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