{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:27:13Z","timestamp":1740126433558,"version":"3.37.3"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Health Labor Science Research on Measures"},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labor and welfare of Japan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,11,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>As natural killer (NK) T cells play an important role in the development of autoimmune diseases, they should have significant roles for the pathogenesis of autoimmune liver disease. Implication of the NK T cells in the generation of autoimmune-related hepatic inflammation was investigated using a novel mouse model. Immunization of mice with dendritic cells (DCs) loaded with hepatocyte-mimicking hepatocellular carcinoma cells (DC\/Hepa1-6) induces cytotoxic T lymphocytes (CTL) capable of killing hepatocytes. Subsequent administration of interleukin (IL)-12, a potent interferon-gamma (IFN-\u03b3) inducer, to the immunized mice generates autoimmune hepatic inflammation (AHI), as reported previously. Upon onset of the AHI response, the number of intrahepatic CD3+NK1\u00b71+NK T cells increased markedly, along with a decrease in the number of splenic NK T cells, augmented expression of CXCR6 on intrahepatic NK T cells and CXCL16 in hepatic tissue, suggesting that NK T cells were recruited into the inflamed liver. The NK T cells were strongly positive for CD69 and produced IFN-\u03b3, but not IL-4. AHI activity was attenuated markedly in CD1d\u2013\/\u2013NK T cell-deficient mice, indicating that NK T cells play a pivotal role in the development of AHI. Mice treated with DC\/Hepa1-6 and alpha-galactosylceramide, a potent NK T cell activator, also exhibited similar hepatic inflammation, in which activated NK T cells producing IFN-\u03b3 and CD8+ T cells cytotoxic to hepatocytes were induced in liver-infiltrating mononuclear cells. Activated NK T cells producing IFN-\u03b3 potentiate DC-based AHI in the mouse model.<\/jats:p>","DOI":"10.1111\/j.1365-2249.2012.04664.x","type":"journal-article","created":{"date-parts":[[2012,8,21]],"date-time":"2012-08-21T11:51:12Z","timestamp":1345549872000},"page":"274-282","source":"Crossref","is-referenced-by-count":12,"title":["Activated natural killer T cells producing interferon-gamma elicit promoting activity to murine dendritic cell-based autoimmune hepatic inflammation"],"prefix":"10.1093","volume":"170","author":[{"given":"M","family":"Nakano","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan"},{"name":"Department of Oncology, Institute of DNA Medicine, Jikei University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Saeki","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan"},{"name":"Department of Oncology, Institute of DNA Medicine, Jikei University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Homma","sequence":"additional","affiliation":[{"name":"Department of Oncology, Institute of DNA Medicine, Jikei University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Tajiri","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Zeniya","sequence":"additional","affiliation":[{"name":"Gastroenterology, Jikei University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2012,11,1]]},"reference":[{"key":"2021122708261061600_cei4664-bib-0001","first-page":"390916","article-title":"Autoimmune hepatitis: a review of current diagnosis and treatment","volume":"2011","author":"Makol","year":"2011","journal-title":"Hepat Res Treat"},{"key":"2021122708261061600_cei4664-bib-0002","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s12072-010-9183-5","article-title":"Autoimmune hepatitis: new paradigms in the pathogenesis, diagnosis, and management","volume":"4","author":"Oo","year":"2010","journal-title":"Hepatol 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