{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:27:13Z","timestamp":1740126433604,"version":"3.37.3"},"reference-count":59,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100008578","name":"Swiss Life Jubil\u00e4umsstiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008578","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["330030\u2013131008211","PPOOP3-135170"],"award-info":[{"award-number":["330030\u2013131008211","PPOOP3-135170"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,11,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>One approach to fight against schistosomiasis is to develop an efficient vaccine. Schistosoma mansoni tetraspanning orphan receptor (SmTOR) might be a vaccine candidate, as it is a tegument membrane protein expressed most highly in cercariae. In this study we characterized the recombinant first extracellular domain of SmTOR (rSmTORed1) as having the expected property to bind C2 of complement similarly to a smaller peptide of the same domain, and to produce specific and high-titre antibodies in BALB\/c mice immunized using complete Freund's adjuvant\/incomplete Freund's adjuvant (CFA\/IFA). Immunization was protective against parasite infection, as demonstrated by a significant decrease in worm burden in immunized BALB\/c mice versus the control groups over two independent trials [64 and 45% reduction for mean adult worm burden in immunized versus phosphate-bufferd saline (PBS) injected mice]. Interestingly, infection by itself did not lead to the generation of anti-rSmTORed1 antibodies, corresponding to the low frequency of specific anti-rSmTORed1 antibodies detected in the sera of patients infected with S. mansoni (2\/20; 10%). These data suggest that, as opposed to the natural infection during which SmTOR induces antibodies only rarely, immunization with its smaller first extracellular domain might be more efficient.<\/jats:p>","DOI":"10.1111\/j.1365-2249.2012.04667.x","type":"journal-article","created":{"date-parts":[[2012,8,24]],"date-time":"2012-08-24T07:38:46Z","timestamp":1345793926000},"page":"342-357","source":"Crossref","is-referenced-by-count":6,"title":["<i>Schistosoma mansoni<\/i>tetraspanning orphan receptor (SmTOR): a new vaccine candidate against schistosomiasis"],"prefix":"10.1093","volume":"170","author":[{"given":"C","family":"Lochmatter","sequence":"first","affiliation":[{"name":"Immunonephrology Laboratory, Department of Biomedicine, University Hospital Basel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C L","family":"Schneider","sequence":"additional","affiliation":[{"name":"Immunonephrology Laboratory, Department of Biomedicine, University Hospital Basel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Ingram","sequence":"additional","affiliation":[{"name":"Swiss Tropical and Public Health Institute, Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Keiser","sequence":"additional","affiliation":[{"name":"Swiss Tropical and Public Health Institute, Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J A","family":"Schifferli","sequence":"additional","affiliation":[{"name":"Immunonephrology Laboratory, Department of Biomedicine, University Hospital Basel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2012,11,1]]},"reference":[{"key":"2021122708261196000_cei4667-bib-0001","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/nri1183","article-title":"Immune regulation by helminth parasites: cellular and molecular mechanisms","volume":"3","author":"Maizels","year":"2003","journal-title":"Nat Rev Immunol"},{"key":"2021122708261196000_cei4667-bib-0002","first-page":"53","article-title":"A contribution to human helminthology","volume":"4","author":"Bilharz","year":"1852\u201353","journal-title":"Zeitsch Wissensch Zool"},{"key":"2021122708261196000_cei4667-bib-0003","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0001-706X(00)00121-2","article-title":"From katayama to the Dakhla Oasis: the beginning of epidemiology and control of bilharzia","volume":"77","author":"Jordan","year":"2000","journal-title":"Acta Trop"},{"key":"2021122708261196000_cei4667-bib-0004","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S1473-3099(06)70521-7","article-title":"Schistosomiasis and water resources development: systematic review, meta-analysis, and estimates of people at risk","volume":"6","author":"Steinmann","year":"2006","journal-title":"Lancet Infect Dis"},{"key":"2021122708261196000_cei4667-bib-0005","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1007\/s00436-009-1371-7","article-title":"Current chemotherapy arsenal for Schistosomiasis mansoni: alternatives and challenges","volume":"104","author":"Abdul-Ghani","year":"2009","journal-title":"Parasitol Res"},{"key":"2021122708261196000_cei4667-bib-0006","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1097\/QCO.0b013e328318978f","article-title":"Praziquantel: mechanisms of action, resistance and new derivatives for schistosomiasis","volume":"21","author":"Doenhoff","year":"2008","journal-title":"Curr Opin Infect Dis"},{"key":"2021122708261196000_cei4667-bib-0007","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.cbpa.2007.05.031","article-title":"Chemotherapy of schistosomiasis: present and future","volume":"11","author":"Caffrey","year":"2007","journal-title":"Curr Opin Chem Biol"},{"key":"2021122708261196000_cei4667-bib-0008","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/0014-4894(86)90184-0","article-title":"Schistosoma mansoni: chemotherapy of infections of different ages","volume":"61","author":"Sabah","year":"1986","journal-title":"Exp Parasitol"},{"key":"2021122708261196000_cei4667-bib-0009","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1128\/CMR.00046-07","article-title":"Current status of vaccines for schistosomiasis","volume":"21","author":"McManus","year":"2008","journal-title":"Clin Microbiol Rev"},{"key":"2021122708261196000_cei4667-bib-0010","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/j.1600-065X.1999.tb01346.x","article-title":"The search for a vaccine against schistosomiasis \u2013 a difficult path but an achievable goal","volume":"171","author":"McManus","year":"1999","journal-title":"Immunol Rev"},{"key":"2021122708261196000_cei4667-bib-0011","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1017\/S003118200999093X","article-title":"Schistosomiasis \u2013 a rich vein of research","volume":"136","author":"Hagan","year":"2009","journal-title":"Parasitology"},{"key":"2021122708261196000_cei4667-bib-0012","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/nature08160","article-title":"The genome of the blood fluke Schistosoma mansoni","volume":"460","author":"Berriman","year":"2009","journal-title":"Nature"},{"key":"2021122708261196000_cei4667-bib-0013","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.pt.2007.02.007","article-title":"Integrating transcriptome, proteome and glycome analyses of Schistosoma biology","volume":"23","author":"Hokke","year":"2007","journal-title":"Trends Parasitol"},{"key":"2021122708261196000_cei4667-bib-0014","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.pt.2006.10.002","article-title":"\u2018Oming in on schistosomes: prospects and limitations for post-genomics","volume":"23","author":"Wilson","year":"2007","journal-title":"Trends Parasitol"},{"key":"2021122708261196000_cei4667-bib-0015","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.ijpara.2006.12.001","article-title":"Schistosome membrane proteins as vaccines","volume":"37","author":"Loukas","year":"2007","journal-title":"Int J Parasitol"},{"key":"2021122708261196000_cei4667-bib-0016","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1590\/S0074-02762006000900004","article-title":"Schistosome vaccines: a critical appraisal","volume":"101","author":"Wilson","year":"2006","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"2021122708261196000_cei4667-bib-0017","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1590\/S0074-02762006000900032","article-title":"Proteomic analysis of the shistosome tegument and its surface membranes","volume":"101","author":"Braschi","year":"2006","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"2021122708261196000_cei4667-bib-0018","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1002\/pmic.200500368","article-title":"The tegument surface membranes of the human blood parasite Schistosoma mansoni: a proteomic analysis after differential extraction","volume":"6","author":"Braschi","year":"2006","journal-title":"Proteomics"},{"key":"2021122708261196000_cei4667-bib-0019","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1074\/mcp.M500287-MCP200","article-title":"Proteins exposed at the adult schistosome surface revealed by biotinylation","volume":"5","author":"Braschi","year":"2006","journal-title":"Mol Cell Proteomics"},{"key":"2021122708261196000_cei4667-bib-0020","doi-asserted-by":"crossref","first-page":"e262","DOI":"10.1371\/journal.pntd.0000262","article-title":"Proteomic analysis of skin invasion by blood fluke larvae","volume":"2","author":"Hansell","year":"2008","journal-title":"PLoS Negl Trop Dis"},{"key":"2021122708261196000_cei4667-bib-0021","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.pt.2004.05.007","article-title":"Immunoparasitology series: intravascular schistosomes and complement","volume":"20","author":"Skelly","year":"2004","journal-title":"Trends Parasitol"},{"key":"2021122708261196000_cei4667-bib-0022","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1017\/S0031182009005757","article-title":"Schistosoma mansoni TOR is a tetraspanning orphan receptor on the parasite surface","volume":"136","author":"Lochmatter","year":"2009","journal-title":"Parasitology"},{"key":"2021122708261196000_cei4667-bib-0023","doi-asserted-by":"crossref","first-page":"5213","DOI":"10.4049\/jimmunol.168.10.5213","article-title":"Complement C2 receptor inhibitor trispanning and the beta-chain of C4 share a binding site for complement C2","volume":"168","author":"Inal","year":"2002","journal-title":"J Immunol"},{"key":"2021122708261196000_cei4667-bib-0024","doi-asserted-by":"crossref","first-page":"206","DOI":"10.2144\/98252bm05","article-title":"Sticky-end PCR: new method for subcloning","volume":"25","author":"Zeng","year":"1998","journal-title":"Biotechniques"},{"key":"2021122708261196000_cei4667-bib-0025","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.pep.2005.01.016","article-title":"Protein production by auto-induction in high density shaking cultures","volume":"41","author":"Studier","year":"2005","journal-title":"Protein Exp Purif"},{"key":"2021122708261196000_cei4667-bib-0026","doi-asserted-by":"crossref","first-page":"3475","DOI":"10.1091\/mbc.e10-03-0182","article-title":"The rapamycin-sensitive phosphoproteome reveals that TOR controls protein kinase A toward some but not all substrates","volume":"21","author":"Soulard","year":"2010","journal-title":"Mol Biol Cell"},{"key":"2021122708261196000_cei4667-bib-0027","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ab.2009.05.028","article-title":"Protein\u2013protein interaction studies on protein arrays: effect of detection strategies on signal-to-background ratios","volume":"392","author":"Hurst","year":"2009","journal-title":"Anal Biochem"},{"key":"2021122708261196000_cei4667-bib-0028","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1021\/cb800025k","article-title":"HaloTag: a novel protein labeling technology for cell imaging and protein analysis","volume":"3","author":"Los","year":"2008","journal-title":"ACS Chem Biol"},{"key":"2021122708261196000_cei4667-bib-0029","doi-asserted-by":"crossref","first-page":"e308","DOI":"10.1371\/journal.pntd.0000308","article-title":"Schistosoma mansoni tegument protein Sm29 is able to induce a Th1-type of immune response and protection against parasite infection","volume":"2","author":"Cardoso","year":"2008","journal-title":"PLoS Negl Trop Dis"},{"key":"2021122708261196000_cei4667-bib-0030","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1017\/S0031182009990965","article-title":"Morphological effects and tegumental alterations induced by mefloquine on schistosomula and adult flukes of Schistosoma mansoni","volume":"137","author":"Manneck","year":"2010","journal-title":"Parasitology"},{"key":"2021122708261196000_cei4667-bib-0031","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0022-2836(91)90856-2","article-title":"Controlling basal expression in an inducible T7 expression system by blocking the target T7 promoter with lac repressor","volume":"219","author":"Dubendorff","year":"1991","journal-title":"J Mol Biol"},{"key":"2021122708261196000_cei4667-bib-0032","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0014-5793(00)01304-1","article-title":"A Schistosoma protein, Sh-TOR, is a novel inhibitor of complement which binds human C2","volume":"470","author":"Inal","year":"2000","journal-title":"FEBS Lett"},{"key":"2021122708261196000_cei4667-bib-0033","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0167-4781(99)00051-2","article-title":"Schistosoma TOR (trispanning orphan receptor), a novel, antigenic surface receptor of the blood-dwelling, Schistosoma parasite","volume":"1445","author":"Inal","year":"1999","journal-title":"Biochim Biophys Acta"},{"key":"2021122708261196000_cei4667-bib-0034","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.bbapap.2008.12.010","article-title":"Stability improvement of the fatty acid binding protein Sm14 from S. mansoni by Cys replacement: structural and functional characterization of a vaccine candidate","volume":"1794","author":"Ramos","year":"2009","journal-title":"Biochim Biophys Acta"},{"key":"2021122708261196000_cei4667-bib-0035","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1097\/01.shk.0000142249.08135.e9","article-title":"Innate immune response in Th1- and Th2-dominant mouse strains","volume":"22","author":"Watanabe","year":"2004","journal-title":"Shock"},{"key":"2021122708261196000_cei4667-bib-0036","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/j.intimp.2006.01.021","article-title":"Impact of interleukin-1 and interleukin-6 in murine primary schistosomiasis","volume":"6","author":"El Ridi","year":"2006","journal-title":"Int Immunopharmacol"},{"key":"2021122708261196000_cei4667-bib-0037","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.cyto.2006.01.009","article-title":"Influence of interleukin-2 and interferon-gamma in murine schistosomiasis","volume":"33","author":"El Ridi","year":"2006","journal-title":"Cytokine"},{"key":"2021122708261196000_cei4667-bib-0038","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1046\/j.1365-3083.2001.00992.x","article-title":"Human and murine humoral immune recognition of multiple peptides from Schistosoma mansoni glyceraldehyde 3-P dehydrogenase is associated with resistance to Schistosomiasis","volume":"54","author":"El Ridi","year":"2001","journal-title":"Scand J Immunol"},{"key":"2021122708261196000_cei4667-bib-0039","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1016\/S0264-410X(97)00081-9","article-title":"Protection against Schistosoma mansoni infection with a recombinant baculovirus-expressed subunit of calpain","volume":"15","author":"Hota-Mitchell","year":"1997","journal-title":"Vaccine"},{"key":"2021122708261196000_cei4667-bib-0040","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0169-4758(97)01207-6","article-title":"Schistosomiasis vaccine:research to development","volume":"14","author":"Bergquist","year":"1998","journal-title":"Parasitol Today"},{"key":"2021122708261196000_cei4667-bib-0041","doi-asserted-by":"crossref","first-page":"e820","DOI":"10.1371\/journal.pntd.0000820","article-title":"Analysis of complex patterns of human exposure and immunity to Schistosomiasis mansoni: the influence of age, sex, ethnicity and IgE","volume":"4","author":"Pinot de Moira","year":"2010","journal-title":"PLoS Negl Trop Dis"},{"key":"2021122708261196000_cei4667-bib-0042","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1146\/annurev.me.43.020192.001233","article-title":"Immunologic aspects of schistosomiasis","volume":"43","author":"Capron","year":"1992","journal-title":"Annu Rev Med"},{"key":"2021122708261196000_cei4667-bib-0043","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.4049\/jimmunol.126.3.1025","article-title":"Studies of the antibody-dependent killing of schistosomula of Schistosoma mansoni employing haptenic target antigens. II. In vitro killing of TNP-schistosomula by human eosinophils and neutrophils","volume":"126","author":"Moser","year":"1981","journal-title":"J Immunol"},{"key":"2021122708261196000_cei4667-bib-0044","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1002\/j.1460-2075.1983.tb01404.x","article-title":"Anti-schistosome monoclonal antibodies of different isotypes \u2013 correlation with cytotoxicity","volume":"2","author":"Horowitz","year":"1983","journal-title":"EMBO J"},{"key":"2021122708261196000_cei4667-bib-0045","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/367183a0","article-title":"High-affinity IgE receptor on eosinophils is involved in defence against parasites","volume":"367","author":"Gounni","year":"1994","journal-title":"Nature"},{"key":"2021122708261196000_cei4667-bib-0046","first-page":"577","article-title":"Enhancement of human eosinophil- and neutrophil-mediated killing of schistosomula of Schistosoma mansoni by reversed type (IgE-mediated) anaphylaxis in vitro","volume":"59","author":"Moqbel","year":"1985","journal-title":"Clin Exp Immunol"},{"key":"2021122708261196000_cei4667-bib-0047","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1172\/JCI110037","article-title":"Role of cell-generated hydrogen peroxide in granulocyte-mediated killing of schistosomula of Schistosoma mansoni in vitro","volume":"67","author":"Kazura","year":"1981","journal-title":"J Clin Invest"},{"key":"2021122708261196000_cei4667-bib-0048","doi-asserted-by":"crossref","first-page":"76","DOI":"10.4269\/ajtmh.1978.27.76","article-title":"Immunization of mice with Co-60 irradiated Schistosoma mansoni cercariae","volume":"27","author":"Minard","year":"1978","journal-title":"Am J Trop Med Hyg"},{"key":"2021122708261196000_cei4667-bib-0049","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.pt.2005.01.001","article-title":"Vaccine-linked chemotherapy: can schistosomiasis control benefit from an integrated approach?","volume":"21","author":"Bergquist","year":"2005","journal-title":"Trends Parasitol"},{"key":"2021122708261196000_cei4667-bib-0050","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.actatropica.2008.09.002","article-title":"The biotechnology-value chain: development of Sm14 as a schistosomiasis vaccine","volume":"108","author":"Tendler","year":"2008","journal-title":"Acta Trop"},{"key":"2021122708261196000_cei4667-bib-0051","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1111\/j.1365-3024.2003.00651.x","article-title":"A DNA-prime\/protein-boost vaccination regimen enhances Th2 immune responses but not protection following Schistosoma mansoni infection","volume":"25","author":"Da'Dara","year":"2003","journal-title":"Parasite Immunol"},{"key":"2021122708261196000_cei4667-bib-0052","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0264-410X(01)00374-7","article-title":"Immunization with plasmid DNA encoding the integral membrane protein, Sm23, elicits a protective immune response against schistosome infection in mice","volume":"20","author":"Da'dara","year":"2001","journal-title":"Vaccine"},{"key":"2021122708261196000_cei4667-bib-0053","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1038\/nm1430","article-title":"Tetraspanins on the surface of Schistosoma mansoni are protective antigens against schistosomiasis","volume":"12","author":"Tran","year":"2006","journal-title":"Nat Med"},{"key":"2021122708261196000_cei4667-bib-0054","doi-asserted-by":"crossref","first-page":"e597","DOI":"10.1371\/journal.pntd.0000597","article-title":"Schistosoma mansoni stomatin like protein-2 is located in the tegument and induces partial protection against challenge infection","volume":"4","author":"Farias","year":"2010","journal-title":"PLoS Negl Trop Dis"},{"key":"2021122708261196000_cei4667-bib-0055","doi-asserted-by":"crossref","first-page":"5526","DOI":"10.1128\/IAI.72.9.5526-5529.2004","article-title":"Parameters of the attenuated schistosome vaccine evaluated in the olive baboon","volume":"72","author":"Kariuki","year":"2004","journal-title":"Infect Immun"},{"key":"2021122708261196000_cei4667-bib-0056","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.pt.2009.05.011","article-title":"Immune effector mechanisms against schistosomiasis: looking for a chink in the parasite's armour","volume":"25","author":"Wilson","year":"2009","journal-title":"Trends Parasitol"},{"key":"2021122708261196000_cei4667-bib-0057","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/S1471-4922(00)01770-0","article-title":"Bird schistosomes: do they die in mammalian skin?","volume":"17","author":"Horak","year":"2001","journal-title":"Trends Parasitol"},{"key":"2021122708261196000_cei4667-bib-0058","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1111\/j.1365-3024.2008.01059.x","article-title":"Antibody responses induced by Trichobilharzia regenti antigens in murine and human hosts exhibiting cercarial dermatitis","volume":"30","author":"Lichtenbergova","year":"2008","journal-title":"Parasite Immunol"},{"key":"2021122708261196000_cei4667-bib-0059","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1017\/S0950268898008826","article-title":"Public health importance and risk factors for cercarial dermatitis associated with swimming in Lake Leman at Geneva, Switzerland","volume":"120","author":"Chamot","year":"1998","journal-title":"Epidemiol Infect"}],"container-title":["Clinical and Experimental Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2249.2012.04667.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/cei\/article-pdf\/170\/3\/342\/41907007\/cei4667.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cei\/article-pdf\/170\/3\/342\/41907007\/cei4667.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,28]],"date-time":"2024-04-28T17:29:39Z","timestamp":1714325379000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cei\/article\/170\/3\/342\/6429086"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,1]]},"references-count":59,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2012,11,1]]},"published-print":{"date-parts":[[2012,11,1]]}},"URL":"https:\/\/doi.org\/10.1111\/j.1365-2249.2012.04667.x","relation":{},"ISSN":["0009-9104","1365-2249"],"issn-type":[{"type":"print","value":"0009-9104"},{"type":"electronic","value":"1365-2249"}],"subject":[],"published-other":{"date-parts":[[2012,12]]},"published":{"date-parts":[[2012,11,1]]}}}