{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T04:26:50Z","timestamp":1769747210374,"version":"3.49.0"},"reference-count":7,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,12,14]],"date-time":"2006-12-14T00:00:00Z","timestamp":1166054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>This 22\u2010year\u2010old women presented to the ante\u2010natal clinic of this hospital for prenatal screening for <jats:italic>\u03b2<\/jats:italic>\u2010thalassemia. Cation exchange high performance liquid chromatography (HPLC) using \u2018Beta Thalassemia Short Program\u2019 on Bio\u2010Rad \u2018Variant\u2019 system revealed HbC value of 81.6%. The CBC showed microcytic hypochromic anemia. The HPLC and CBC suggested the possibility of compound heterozygote state for HbC\/<jats:italic>\u03b2<\/jats:italic>\u2010thalassemia. The alkali and acid electrophoresis findings were consistent with the above diagnosis. The DNA analysis confirmed compound heterozygote state for HbC\/<jats:italic>\u03b2<\/jats:italic><jats:sup>0<\/jats:sup>\u2010thalassemia (Fr 8\/9 mutation). The studies on the parents showed that mother was a compound heterozygote for HbD<jats:sup>Punjab<\/jats:sup> and HbC while father had <jats:italic>\u03b2<\/jats:italic>\u2010thalassemia trait. To the best of our knowledge, this is the first confirmed report of HbC from India. The paper discusses the hematological findings in this subject and her mother (a compound heterozygote for HbD<jats:sup>Punjab<\/jats:sup> and HbC).<\/jats:p>","DOI":"10.1111\/j.1365-2257.2006.00850.x","type":"journal-article","created":{"date-parts":[[2006,12,14]],"date-time":"2006-12-14T23:01:06Z","timestamp":1166137266000},"page":"381-385","source":"Crossref","is-referenced-by-count":7,"title":["Case report of HbC\/<i>\u03b2<\/i><sup>0<\/sup>\u2010thalassemia from India"],"prefix":"10.1111","volume":"29","author":[{"given":"S.","family":"KUMAR","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"RANA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"HANDOO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"SAXENA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. 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K.","family":"SOOD","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,12,15]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"155","volume-title":"Haemoglobinopathy Diagnosis","author":"Bain B.J.","year":"2001"},{"key":"e_1_2_5_3_1","first-page":"1536","article-title":"The burden of hemoglobinopathies in India and the challenges ahead","volume":"79","author":"Balgir R.S.","year":"2000","journal-title":"Current Science"},{"key":"e_1_2_5_4_1","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1080\/09723757.2003.11885855","article-title":"Spectrum of \u03b2\u2010thalassemia mutations in Punjabis","volume":"3","author":"Garewal G.","year":"2003","journal-title":"International Journal of Human Genetics"},{"key":"e_1_2_5_5_1","first-page":"855","article-title":"Hemoglobinopathies among five major ethinic groups in Karachi, Pakistan","volume":"33","author":"Ghani R.","year":"2002","journal-title":"Southeast Asian Journal of Tropical Medicine and Public Health"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/17.7.2503"},{"key":"e_1_2_5_7_1","first-page":"225","volume-title":"Trends in Haematology","author":"Sukumaran P.K.","year":"1975"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470696705"}],"container-title":["International Journal of Laboratory Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2257.2006.00850.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2257.2006.00850.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T13:53:32Z","timestamp":1697032412000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2257.2006.00850.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12,15]]},"references-count":7,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007,10]]}},"alternative-id":["10.1111\/j.1365-2257.2006.00850.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2257.2006.00850.x","archive":["Portico"],"relation":{},"ISSN":["1751-5521","1751-553X"],"issn-type":[{"value":"1751-5521","type":"print"},{"value":"1751-553X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,12,15]]}}}