{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T16:21:36Z","timestamp":1782750096713,"version":"3.54.5"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2007,1,10]],"date-time":"2007-01-10T00:00:00Z","timestamp":1168387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The aim of this study was to test the clinical utility of reticulocyte parameters in differential diagnosis in iron deficiency anemia (IDA), vitamin B<jats:sub>12<\/jats:sub> deficiency (B12) and <jats:italic>\u03b2<\/jats:italic>\u2010thalassemia minor (TM). We analyzed the percentage of reticulocyte, absolute reticulocyte count, mean content hemoglobin of reticulocyte (CHr), mean corpuscular volume of reticulocyte (MCVr), corpuscular hemoglobin concentration mean of reticulocyte (CHCMr), MCVr\/MCV ratio, CHr\/CH ratio and CHCMr\/CHCM ratio in healthy donors (<jats:italic>n<\/jats:italic>\u2003=\u200334), iron deficiency (IDA) (<jats:italic>n<\/jats:italic>\u2003=\u200341), vitamin B<jats:sub>12<\/jats:sub> deficiency (B12) (<jats:italic>n<\/jats:italic>\u2003=\u200322), and TM (<jats:italic>n<\/jats:italic>\u2003=\u200334). This study demonstrates that the cutoff value of CHr was 25.7 as indicative of IDA (85.4% sensitivity, 97.1% specificity). CHr and MCVr may be useful for TM (cutoff value\u2003\u2264\u200324.8 for CHr) and B12 (&gt;102.1, cutoff value for MCVr), respectively. Sensitivity and specificity of these parameters were 90.9, 86.4% and 97.1, 82.4%, respectively. CHCMr is useful to differentiate IDA and TM from B12. While CHr was low value in microcytic groups (mean 21.8\u2003\u00b1\u20033.3 for IDA, 21.0\u2003\u00b1\u20032.9 for TM), it was high in B12 (mean 32.1\u2003\u00b1\u20035.7). However, that of CHr\/CH ratio was only significantly in IDA group compared with the control (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05, mean 0.98). Therefore, there are limitations regarding CHr and CHr\/CH ratio differential diagnosis in microcytic and macrocytic groups. CHr, MCVr, and CHCMr are not sufficiently sensitive and specific to differentiate TM from IDA. We conclude that measurement of reticulocyte count and parameters may be a very useful implement in the diagnosis of IDA and TM.<\/jats:p>","DOI":"10.1111\/j.1365-2257.2006.00872.x","type":"journal-article","created":{"date-parts":[[2007,1,10]],"date-time":"2007-01-10T09:14:28Z","timestamp":1168420468000},"page":"327-334","source":"Crossref","is-referenced-by-count":33,"title":["Evaluation of reticulocyte parameters in iron deficiency, vitamin B<sub>12<\/sub> deficiency and <i>\u03b2<\/i>\u2010thalassemia minor patients"],"prefix":"10.1111","volume":"29","author":[{"given":"C.","family":"CEYLAN","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"MISKIO\u011eLU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"\u00c7OLAK","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"KILI\u00c7\u00c7IO\u011eLU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"\u00d6ZDEMIR","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,1,10]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"575","article-title":"The clinical utility of discriminant functions for the differential diagnosis of microcytic anemias","volume":"15","author":"Bentley S.A.","year":"1989","journal-title":"Blood Cells"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(97)90087-1"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s005990050011"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408360091174196"},{"key":"e_1_2_6_6_1","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1093\/clinchem\/48.7.981","article-title":"A hematologic \u2018\u2018gold standard\u2019\u2019 for iron\u2010deficient states","volume":"48","author":"Brugnara C.","year":"2002","journal-title":"Clinical Chemistry"},{"key":"e_1_2_6_7_1","first-page":"660","article-title":"Effects of subcutaneous recombinant human erythropoietin in normal subjects: development of decreased reticulocyte hemoglobin content and iron\u2010deficient erythropoiesis","volume":"123","author":"Brugnara C.","year":"1994","journal-title":"Journal of Laboratory and Clinical Medicine"},{"key":"e_1_2_6_8_1","doi-asserted-by":"crossref","first-page":"3100","DOI":"10.1182\/blood.V83.10.3100.3100","article-title":"Reticulocyte hemoglobin content (CHr): early indicator of iron deficiency and response to therapy (letter)","volume":"83","author":"Brugnara C.","year":"1994","journal-title":"Blood"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.281.23.2225"},{"key":"e_1_2_6_10_1","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1182\/blood.V85.3.818.bloodjournal853818","article-title":"Simultaneous measurement of reticulocyte and red blood cell indices in healthy subjects and patients with microcytic and macrocytic anemia","volume":"85","author":"D'Onoforio G.","year":"1995","journal-title":"Blood"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/39.3.437"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365510500406910"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1997.323"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2003.00826.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.4.1489"},{"key":"e_1_2_6_16_1","first-page":"882","article-title":"Differentiation of iron deficiency from thalassemia trait","volume":"1","author":"Mentzer W.C.","year":"1983","journal-title":"Lancet"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(97)90104-9"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s101570300007"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2005.033"},{"key":"e_1_2_6_20_1","first-page":"631","article-title":"Erythroid bone marrow activity and red cell hemoglobinization in iron\u2010sufficient b\u2010thalassemia heterozygotes as reflected by soluble transferrin receptor andreticulocyte hemoglobin content. Correlation with genotypes and Hb A2 levels","volume":"88","author":"Skarmoutsou C.","year":"2003","journal-title":"Haematologica"},{"key":"e_1_2_6_21_1","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1093\/clinchem\/48.7.1066","article-title":"Biochemical and hematologic indices in diagnosis of functional iron deficiency","volume":"48","author":"Thomas C.","year":"2002","journal-title":"Clinical Chemistry"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.5414\/CNP59115"},{"key":"e_1_2_6_23_1","first-page":"193","article-title":"Two new HDW\u2010based indexes to identify b\u2010thalassemia trait","volume":"8","author":"Vicinanza P.","year":"2002","journal-title":"Laboratory Hematology"}],"container-title":["International Journal of Laboratory Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2257.2006.00872.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2257.2006.00872.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T13:53:00Z","timestamp":1697032380000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2257.2006.00872.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1,10]]},"references-count":22,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007,10]]}},"alternative-id":["10.1111\/j.1365-2257.2006.00872.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2257.2006.00872.x","archive":["Portico"],"relation":{},"ISSN":["1751-5521","1751-553X"],"issn-type":[{"value":"1751-5521","type":"print"},{"value":"1751-553X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,1,10]]}}}