{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:22:57Z","timestamp":1760188977306},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,3,17]],"date-time":"2008-03-17T00:00:00Z","timestamp":1205712000000},"content-version":"vor","delay-in-days":12859,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[1973,1]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>The course of thyrotoxicosis treated with antithyroid drugs has been studied in detail in 105 thyrotoxic patients. Each patient was seen at intervals of 1\u20133 months over a period of more than 4 years and thus an average of thirty serial tests of thyroid function were made on each patient. Forty\u2010three patients remitted after one course of antithyroid drugs. In another forty\u2010three patients the disease either required operative treatment or was still active 4 years after the start of therapy. The remaining nineteen patients fell into an intermediate group.<\/jats:p><jats:p>In the light of the variable course of the disease, we conclude that most patients with Graves' disease under 45 years are best treated initially with antithyroid drugs. Reassessment of thyroid function at 6\u2010monthly intervals during and for a period after antithyroid drug therapy is useful and permits selection of the most appropriate method of treatment.<\/jats:p>","DOI":"10.1111\/j.1365-2265.1973.tb03483.x","type":"journal-article","created":{"date-parts":[[2008,3,17]],"date-time":"2008-03-17T14:03:24Z","timestamp":1205762604000},"page":"43-50","source":"Crossref","is-referenced-by-count":30,"title":["SEQUENTIAL ASSESSMENT DURING DRUG TREATMENT OF THYROTOXICOSIS"],"prefix":"10.1111","volume":"2","author":[{"given":"W. D.","family":"ALEXANDER","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. G.","family":"McLARTY","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"HORTON","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. D.","family":"PHARMAKIOTIS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,3,17]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"423","article-title":"Studies of the thyroid iodide \u201ctrap\u201d in man","volume":"25","author":"Alexander W.D.","year":"1969","journal-title":"Recent Progress in Hormone Research"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(67)90972-5"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-30-4-540"},{"key":"e_1_2_1_5_1","volume-title":"Clinic Endocrinology","author":"Astwood E.B.","year":"1960"},{"key":"e_1_2_1_6_1","first-page":"131","volume-title":"Medicine","author":"Bayliss R.I.S.","year":"1972"},{"key":"e_1_2_1_7_1","first-page":"383","article-title":"Possibilities of using 99mTc in place of radioiodine in thyroid function studies","volume":"4","author":"Di Grosi O.","year":"1965","journal-title":"Nuclear\u2010Medizin (Stutrgart)"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.4.5784.396"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-29-7-998"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5752.19"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(71)80002-8"},{"key":"e_1_2_1_12_1","unstructured":"McLarty D.G. Alexander W.D. Horton P.&Clark D.H.(1973). (To be published.)."},{"key":"e_1_2_1_13_1","first-page":"225","volume-title":"The Thyroid and its Diseases","author":"Means J.H.","year":"1963"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(68)91830-8"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(67)90973-7"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2265.1973.tb03483.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2265.1973.tb03483.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,11]],"date-time":"2023-11-11T11:56:35Z","timestamp":1699703795000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2265.1973.tb03483.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1973,1]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1973,1]]}},"alternative-id":["10.1111\/j.1365-2265.1973.tb03483.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2265.1973.tb03483.x","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[1973,1]]}}}