{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T17:17:46Z","timestamp":1760548666553},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,3,17]],"date-time":"2008-03-17T00:00:00Z","timestamp":1205712000000},"content-version":"vor","delay-in-days":9878,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[1981,3]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>In forty\u2010two patients with chronic renal failure (CRF), serum concentrations of 25\u2010hydroxy\u2010cholecalciferol (25\u2010OHCC), 24,25\u2010dihydroxy\u2010cholecalciferol (24,25\u2010OH<jats:sub>2<\/jats:sub>CC) and 1,25\u2010dihydroxy\u2010cholecalciferol (1,25\u2010OH<jats:sub>2<\/jats:sub>CC) were measured before and during intermittent haemodialysis (IHD) and in a few cases also after renal transplantation. 25\u2010OHCC and 24,25\u2010OH<jats:sub>2<\/jats:sub>CC were measured by means of a competitive protein binding assay after Sephadex LH 20 chromatography and 1,25\u2010OH<jats:sub>2<\/jats:sub>CC by means of a radioimmunoassay after Sephadex LH 20 and high pressure liquid chromatography (HPLC). In our patients serum values for 25\u2010OHCC and 24,25\u2010OH<jats:sub>2<\/jats:sub>CC showed a seasonal fluctuation as in normal individuals. The concentrations in the serum of 24,25\u2010OH<jats:sub>2<\/jats:sub>CC and 1,25\u2010OH<jats:sub>2<\/jats:sub>CC showed a positive correlation with renal function. With regard to 24,25\u2010OH<jats:sub>2<\/jats:sub>CC this correlation was only found for the 24,25\u2010OH<jats:sub>2<\/jats:sub>CC: 25\u2010OHCC ratio which was used to eliminate the seasonal fluctuation. For both dihydroxylated metabolites subnormal concentrations were found when the creatinine clearance was 40\u201350 ml\/min and lower. It appears that the decrease of the plasma level of these metabolites of Vitamin D preceeds (or is concomitant with) the changes in the serum values of calcium (Ca), phosphorus (P) and parathyroid hormone (PTH) and the diminution of the intestinal absorption of Ca. These findings indicate that patients with CRF should be treated at an early stage of the disease with 1\u03b1\u2010hydroxy\u2010derivatives of Vitamin D in order to prevent the development of, or to induce the healing of, bone\u2010lesions of renal osteodystrophy.<\/jats:p>","DOI":"10.1111\/j.1365-2265.1981.tb00191.x","type":"journal-article","created":{"date-parts":[[2008,3,17]],"date-time":"2008-03-17T13:11:45Z","timestamp":1205759505000},"page":"225-236","source":"Crossref","is-referenced-by-count":54,"title":["SERUM CONCENTRATIONS OF METABOLITES OF VITAMIN D IN PATIENTS WITH CHRONIC RENAL FAILURE (CRF). CONSEQUENCES FOR THE TREATMENT WITH 1\u2010\u03b1\u2010HYDROXY\u2010DERIVATIVES"],"prefix":"10.1111","volume":"14","author":[{"given":"J. R.","family":"JUTTMANN","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. J.","family":"BUURMAN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"DE KAM","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. J.","family":"VISSER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. C.","family":"BIRKENH\u00c4GER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,3,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-46-2-284"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1093\/clinchem\/26.5.562","article-title":"A radioimmunoassay for 1,25\u2010dihydroxycholecalciferol","volume":"26","author":"Bouillon R.","year":"1980","journal-title":"Clinical Chemistry"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.183.4129.1089"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109055"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1979.tb03068.x"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.179.4071.402"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(71)90320-1"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1007\/BF02064117","article-title":"A highly sensitive competitive protein binding assay for 24,25 and 25,26\u2010dihydroxycholecalciferol","volume":"22","author":"Graham R.F.","year":"1977","journal-title":"Calcified Tissue Research"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(77)90519-7"},{"key":"e_1_2_1_11_1","first-page":"38","article-title":"Calciferol metabolism and intestinal calcium transport in the chick with reduced renal function","volume":"83","author":"Hartenbower D.L.","year":"1974","journal-title":"Journal of Laboratory and Clinical Medicine"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1976.tb03823.x"},{"key":"e_1_2_1_13_1","volume-title":"Vitamin D, Basic Research and its Clinical Application","author":"Juttmann J.R.","year":"1979"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.1978.tb00826.x"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02013246"},{"key":"e_1_2_1_16_1","first-page":"1383","article-title":"Is 24,25\u2010dihydroxycholecalciferol a calcium regulating hormone in man","author":"Kanis J.A.","year":"1978","journal-title":"British Medical Journal"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/228763a0"},{"key":"e_1_2_1_18_1","first-page":"626","article-title":"Failure of formation of 1,25\u2010dihydroxycholecalciferol in chronic renal insufficiency","author":"Mawer E.B.","journal-title":"Lancet"},{"key":"e_1_2_1_19_1","doi-asserted-by":"crossref","DOI":"10.1515\/9783112330029","volume-title":"Vitamin D, Basic Research and its Clinical Application","author":"Norman A.W.","year":"1979"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/276517a0"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj1820055"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI106517"},{"key":"e_1_2_1_23_1","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1515\/9783112327203-093","volume-title":"Vitamin D, Biochemical, Chemical and Clinical Aspects Related to Calcium Metabolism","author":"Stern P.A.","year":"1977"},{"key":"e_1_2_1_24_1","first-page":"541","article-title":"The absence of 24,25\u2010dihydroxychoieacalciferol in anephric patients","volume":"55","author":"Taylor C.M.","year":"1978","journal-title":"Clinical Science and Molecular Medicine"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(79)90045-7"},{"key":"e_1_2_1_26_1","first-page":"259","article-title":"The excretion of acid in renal disease","volume":"28","author":"Wrong O.","year":"1959","journal-title":"Quarterly Journal of Medicine"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2265.1981.tb00191.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2265.1981.tb00191.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,11]],"date-time":"2023-11-11T11:35:31Z","timestamp":1699702531000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2265.1981.tb00191.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,3]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1981,3]]}},"alternative-id":["10.1111\/j.1365-2265.1981.tb00191.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2265.1981.tb00191.x","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,3]]}}}