{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T12:32:04Z","timestamp":1770985924996,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,3,17]],"date-time":"2008-03-17T00:00:00Z","timestamp":1205712000000},"content-version":"vor","delay-in-days":9725,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[1981,8]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>In the sera of patients with Graves' disease abnormal thyroid \u2018stimulating\u2019 immunoglobulins have been demonstrated by <jats:italic>in vivo<\/jats:italic> and <jats:italic>in vitro<\/jats:italic> assay systems. Conflicting results have been reported when thyroid stimulating and thyrotrophin (TSH)\u2010binding inhibiting activities have been compared. The present study was performed in forty\u2010nine hyperthyroid Graves' patients to ascertain the relationships among TSH\u2010binding inhibiting immunoglobulins (TBII), measured by a radio\u2010receptor assay, thyroid stimulating antibody (TSAb), assayed by stimulation of adenylate cyclase\u2010cAMP system in human thyroid plasma membranes, and LATS, measured by McKenzie's mouse bioassay. TBII was detected in twenty\u2010one of forty\u2010nine (42\u00b79%), TSAb in thirty\u2010five of forty\u2010nine (714%) and LATS in nineteen of forty\u2010nine (38\u00b78%). TBII was also present in four of sixteen (25%) patients with other thyroid autoimmune disorders. When the results obtained with the different techniques were compared, correlation was found between LATS response and TSAb activity (r = 0\u00b753, <jats:italic>P<\/jats:italic> &lt; 0\u00b7001), while there was no correlation between TSAb and TBII activities and between LATS response and TBII activity. These data confirm that TSAb is a specific and sensitive marker of Graves' disease and suggest that TBII activity is not necessarily synonymous with thyroid stimulation, and could reflect a different phenomenon concomitantly produced.<\/jats:p>","DOI":"10.1111\/j.1365-2265.1981.tb00652.x","type":"journal-article","created":{"date-parts":[[2008,3,17]],"date-time":"2008-03-17T13:06:10Z","timestamp":1205759170000},"page":"175-182","source":"Crossref","is-referenced-by-count":50,"title":["COMPARISON BETWEEN THYROID STIMULATING AND TSH\u2010BINDING INHIBITING IMMUNOGLOBULINS OF GRAVES' DISEASE"],"prefix":"10.1111","volume":"15","author":[{"given":"E.","family":"MACCHIA","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. 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